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A8LS52

- GCH4_DINSH

UniProt

A8LS52 - GCH4_DINSH

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei224 – 2241May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciDSHI398580:GKEL-2447-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Dshi_2411
    OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
    Taxonomic identifieri398580 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
    ProteomesiUP000006833: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367GTP cyclohydrolase FolE2PRO_1000087580Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398580.Dshi_2411.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LS52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8LS52-1 [UniParc]FASTAAdd to Basket

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    MNVYTPDIDK LPNRDEAATA LATLRAWAQT ASAAEIETLD PSVARLLPGD    50
    PSDYPSLARA YPEEFSVDAA YKDSLPDLQN GPSSLIRGAK AQIQHVGISN 100
    FRLPIRFHTR DNGDVTLETS VTGSVSLEAE KKGINMSRIM RTFYGHADET 150
    FSFEVIERTL DAYKSDLESF DARIQMRFSF PMKVESLRSG LSGYQYYDIA 200
    LEVVDVNGQR RKFMHLDYVY SSTCPCSLEL SEHARQFRGQ LATPHSQRSV 250
    ARVSVELTCG ADDCLWFEDL VELCREAIPT ETQVMVKRED EQAFAELNAA 300
    NPIFVEDAAR SFCLALQRDD RIGDFRVVAS HQESLHSHDA VSVLTEGPTF 350
    ASDSLDPRLF QTLFHVG 367
    Length:367
    Mass (Da):41,049
    Last modified:December 4, 2007 - v1
    Checksum:i4111E32BCCDD5A52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV94145.1.
    RefSeqiWP_012179076.1. NC_009952.1.
    YP_001533746.1. NC_009952.1.

    Genome annotation databases

    EnsemblBacteriaiABV94145; ABV94145; Dshi_2411.
    GeneIDi5714067.
    KEGGidsh:Dshi_2411.
    PATRICi21817551. VBIDinShi9476_2510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV94145.1 .
    RefSeqi WP_012179076.1. NC_009952.1.
    YP_001533746.1. NC_009952.1.

    3D structure databases

    ProteinModelPortali A8LS52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398580.Dshi_2411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV94145 ; ABV94145 ; Dshi_2411 .
    GeneIDi 5714067.
    KEGGi dsh:Dshi_2411.
    PATRICi 21817551. VBIDinShi9476_2510.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci DSHI398580:GKEL-2447-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16493 / NCIMB 14021 / DFL 12.

    Entry informationi

    Entry nameiGCH4_DINSH
    AccessioniPrimary (citable) accession number: A8LS52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3