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A8LS52

- GCH4_DINSH

UniProt

A8LS52 - GCH4_DINSH

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Dshi_2411
Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei224 – 2241May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-2447-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Dshi_2411
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367GTP cyclohydrolase FolE2UniRule annotationPRO_1000087580Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_2411.

Structurei

3D structure databases

ProteinModelPortaliA8LS52.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LS52-1 [UniParc]FASTAAdd to Basket

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MNVYTPDIDK LPNRDEAATA LATLRAWAQT ASAAEIETLD PSVARLLPGD    50
PSDYPSLARA YPEEFSVDAA YKDSLPDLQN GPSSLIRGAK AQIQHVGISN 100
FRLPIRFHTR DNGDVTLETS VTGSVSLEAE KKGINMSRIM RTFYGHADET 150
FSFEVIERTL DAYKSDLESF DARIQMRFSF PMKVESLRSG LSGYQYYDIA 200
LEVVDVNGQR RKFMHLDYVY SSTCPCSLEL SEHARQFRGQ LATPHSQRSV 250
ARVSVELTCG ADDCLWFEDL VELCREAIPT ETQVMVKRED EQAFAELNAA 300
NPIFVEDAAR SFCLALQRDD RIGDFRVVAS HQESLHSHDA VSVLTEGPTF 350
ASDSLDPRLF QTLFHVG 367
Length:367
Mass (Da):41,049
Last modified:December 4, 2007 - v1
Checksum:i4111E32BCCDD5A52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV94145.1.
RefSeqiWP_012179076.1. NC_009952.1.
YP_001533746.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV94145; ABV94145; Dshi_2411.
GeneIDi5714067.
KEGGidsh:Dshi_2411.
PATRICi21817551. VBIDinShi9476_2510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV94145.1 .
RefSeqi WP_012179076.1. NC_009952.1.
YP_001533746.1. NC_009952.1.

3D structure databases

ProteinModelPortali A8LS52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_2411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV94145 ; ABV94145 ; Dshi_2411 .
GeneIDi 5714067.
KEGGi dsh:Dshi_2411.
PATRICi 21817551. VBIDinShi9476_2510.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci DSHI398580:GKEL-2447-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiGCH4_DINSH
AccessioniPrimary (citable) accession number: A8LS52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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