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Protein

Alanine racemase

Gene

alr

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Active sitei244Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei292Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciDSHI398580:G1GA2-2430-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:Dshi_2378
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
Proteomesi
  • UP000006833 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001385961 – 349Alanine racemaseAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_2378

Structurei

3D structure databases

ProteinModelPortaliA8LRT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiISHFACA
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A8LRT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATATLSIDL DAIAANWRAL DRASNRRVAT GAVVKADGYG LDAGRVARTL
60 70 80 90 100
AQAGARQFFV AVAEEGVTLR KALGPGPAIN VFSGHMEGDT QAIAGARLTP
110 120 130 140 150
MINSAEQLAR HFEALPRHPF GIQLDTGMNR LGMEADEWAA VAEFALGQGP
160 170 180 190 200
KLVMSHLACA DEPGHAANAA QLAEFHRLTD GITVPRSLSA TGGILLGEAY
210 220 230 240 250
HFDMTRPGIG LYGGAPFGAA EPVVRLSIPV VQVRAVTAGE SVGYGCSWVA
260 270 280 290 300
QSDGAIATLS AGYADGLIRA MSNRAMLYAG DVACPLAGRV SMDLLTVDVS
310 320 330 340
HLDEVPEALD LLCPAQGVDR LAEAAGTIGY EILTSLGPRY ARHYAGGVA
Length:349
Mass (Da):36,244
Last modified:December 4, 2007 - v1
Checksum:i502FB26CAC127A95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000830 Genomic DNA Translation: ABV94114.1
RefSeqiWP_012179045.1, NC_009952.1

Genome annotation databases

EnsemblBacteriaiABV94114; ABV94114; Dshi_2378
KEGGidsh:Dshi_2378

Similar proteinsi

Entry informationi

Entry nameiALR_DINSH
AccessioniPrimary (citable) accession number: A8LRT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 4, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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