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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDSHI398580:G1GA2-3656-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Dshi_3593
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
Proteomesi
  • UP000006833 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei49 – 69HelicalUniRule annotationAdd BLAST21
Transmembranei83 – 103HelicalUniRule annotationAdd BLAST21
Transmembranei111 – 131HelicalUniRule annotationAdd BLAST21
Transmembranei190 – 210HelicalUniRule annotationAdd BLAST21
Transmembranei219 – 239HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000839771 – 267Undecaprenyl-diphosphataseAdd BLAST267

Proteomic databases

PRIDEiA8LQR9

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_3593

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiVFKDRIL
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit

Sequencei

Sequence statusi: Complete.

A8LQR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLFHLILVA VIQGLTEFLP VSSSGHLILL PELSGMADQG QVIDVAVHVG
60 70 80 90 100
TLFAVVLYFR ADVAVAVAGV GRLIRGRIDT PGAFLALCLL IATVPVMVVG
110 120 130 140 150
LALNLTGLDQ ALRSMAVIGW TMLIFGIVLY WADQRGPVTR KAGAWTLRHA
160 170 180 190 200
AIMGLWQALA LIPGTSRSGI TITGARLLGY GREDAAKLSM LMSIPTILAS
210 220 230 240 250
GGLLGVEVAA QADWALLKDA AIGAVFAFGA ALLALTLMMR LLRTVSFTPY
260
VIYRVCLGTI LLIIAYS
Length:267
Mass (Da):28,211
Last modified:December 4, 2007 - v1
Checksum:i3886A159CE3FF41B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000830 Genomic DNA Translation: ABV95326.1
RefSeqiWP_012180249.1, NC_009952.1

Genome annotation databases

EnsemblBacteriaiABV95326; ABV95326; Dshi_3593
KEGGidsh:Dshi_3593

Similar proteinsi

Entry informationi

Entry nameiUPPP_DINSH
AccessioniPrimary (citable) accession number: A8LQR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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