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A8LQR9

- UPPP_DINSH

UniProt

A8LQR9 - UPPP_DINSH

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, Dshi_3593
Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-3634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Dshi_3593
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei49 – 6921Helical; Reviewed predictionAdd
BLAST
Transmembranei83 – 10321Helical; Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Reviewed predictionAdd
BLAST
Transmembranei190 – 21021Helical; Reviewed predictionAdd
BLAST
Transmembranei219 – 23921Helical; Reviewed predictionAdd
BLAST
Transmembranei245 – 26521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Undecaprenyl-diphosphataseUniRule annotationPRO_1000083977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_3593.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiNITIIAW.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LQR9-1 [UniParc]FASTAAdd to Basket

« Hide

MTLFHLILVA VIQGLTEFLP VSSSGHLILL PELSGMADQG QVIDVAVHVG    50
TLFAVVLYFR ADVAVAVAGV GRLIRGRIDT PGAFLALCLL IATVPVMVVG 100
LALNLTGLDQ ALRSMAVIGW TMLIFGIVLY WADQRGPVTR KAGAWTLRHA 150
AIMGLWQALA LIPGTSRSGI TITGARLLGY GREDAAKLSM LMSIPTILAS 200
GGLLGVEVAA QADWALLKDA AIGAVFAFGA ALLALTLMMR LLRTVSFTPY 250
VIYRVCLGTI LLIIAYS 267
Length:267
Mass (Da):28,211
Last modified:December 4, 2007 - v1
Checksum:i3886A159CE3FF41B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV95326.1.
RefSeqiWP_012180249.1. NC_009952.1.
YP_001534927.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV95326; ABV95326; Dshi_3593.
GeneIDi5713825.
KEGGidsh:Dshi_3593.
PATRICi21820005. VBIDinShi9476_3730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV95326.1 .
RefSeqi WP_012180249.1. NC_009952.1.
YP_001534927.1. NC_009952.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_3593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV95326 ; ABV95326 ; Dshi_3593 .
GeneIDi 5713825.
KEGGi dsh:Dshi_3593.
PATRICi 21820005. VBIDinShi9476_3730.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi NITIIAW.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci DSHI398580:GKEL-3634-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiUPPP_DINSH
AccessioniPrimary (citable) accession number: A8LQR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi