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A8LQ56 (IF2_DINSH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:Dshi_3563
OrganismDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12) [Complete proteome] [HAMAP]
Taxonomic identifier398580 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter

Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 832832Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000075604

Regions

Nucleotide binding338 – 3458GTP By similarity
Nucleotide binding385 – 3895GTP By similarity
Nucleotide binding439 – 4424GTP By similarity
Region332 – 481150G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
A8LQ56 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: D82A655A1AA34A03

FASTA83289,918
        10         20         30         40         50         60 
MSDTDGKKTL GLRGGSRTGQ VKQSFSHGRT KNVVVETKRK RVLVPKPGAS ASGGRGSDPK 

        70         80         90        100        110        120 
KPGNATDAEM ERRLRALRAA KANESEEAER RAAEEKAREE ERARRRAEIE AKEREEQERE 

       130        140        150        160        170        180 
ERARQKAEEE EEARKKAEAD ASSKPAAARS KADDPATMDP AAAQAAEARG AGKTGSGPRK 

       190        200        210        220        230        240 
ERTADRAQPR KEQKGKGDDR RRSGKLTLNQ ALSGDGGRQK SMAAMKRKQE RERRKAMGGS 

       250        260        270        280        290        300 
QEREKIVRDV QLPETIVVQE LANRMAERVA DVVKALMKMG MMVTQNQSID ADTAELIIEE 

       310        320        330        340        350        360 
FGHKVVRVSD ADVEDVIATV EDDPADMQPR PPVITVMGHV DHGKTSLLDA IRNAKVVAGE 

       370        380        390        400        410        420 
AGGITQHIGA YQVTTDDGTK LSFLDTPGHA AFTSMRARGA QVTDIVVLVV AADDAVMPQT 

       430        440        450        460        470        480 
IEAINHAKAA KVPMIVAINK IDRPEANPDK VRTDLLQHEV IVEKLSGDVQ DVEVSAINGT 

       490        500        510        520        530        540 
GLDQLLESIA LQAEILELKA NPDRAAEGAV IEAQLDVGRG PVATVLVQKG TLRRGDIFVV 

       550        560        570        580        590        600 
GEQWGKVRAL INDQGERVDE AGPSVPVEVL GLNGTPEAGD VLNVVETEAQ AREIAEYRES 

       610        620        630        640        650        660 
AAKEKRAAAG AATTLEQLMA KAKSDETVAE LPIVVKADVQ GSAEAIVQTM EKIGNEEVRV 

       670        680        690        700        710        720 
RVLHSGVGAI TESDIGLAEA SGAPVFGFNV RANAPARNAA QQKGVEIRYY SIIYDLVDDV 

       730        740        750        760        770        780 
KAAASGLLSA EVRENFIGYA EIREVFKVSG VGKVAGCLVT DGIARRSAGV RLLRDNVVIH 

       790        800        810        820        830 
EGTLKTLKRF KDEVKEVQSG QECGMAFENY DDIRPGDVIE IFEREEVERN LE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000830 Genomic DNA. Translation: ABV95296.1.
RefSeqYP_001534897.1. NC_009952.1.

3D structure databases

ProteinModelPortalA8LQ56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398580.Dshi_3563.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV95296; ABV95296; Dshi_3563.
GeneID5713794.
KEGGdsh:Dshi_3563.
PATRIC21819939. VBIDinShi9476_3698.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMAHKITDVI.
OrthoDBEOG67HJSV.

Enzyme and pathway databases

BioCycDSHI398580:GKEL-3603-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_DINSH
AccessionPrimary (citable) accession number: A8LQ56
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries