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A8LQ56

- IF2_DINSH

UniProt

A8LQ56 - IF2_DINSH

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi338 – 3458GTPUniRule annotation
    Nucleotide bindingi385 – 3895GTPUniRule annotation
    Nucleotide bindingi439 – 4424GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDSHI398580:GKEL-3603-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:Dshi_3563
    OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
    Taxonomic identifieri398580 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
    ProteomesiUP000006833: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 832832Translation initiation factor IF-2PRO_1000075604Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398580.Dshi_3563.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LQ56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini329 – 497169tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni338 – 3458G1By similarity
    Regioni363 – 3675G2By similarity
    Regioni385 – 3884G3By similarity
    Regioni439 – 4424G4By similarity
    Regioni475 – 4773G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiHKITDVI.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8LQ56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTDGKKTL GLRGGSRTGQ VKQSFSHGRT KNVVVETKRK RVLVPKPGAS    50
    ASGGRGSDPK KPGNATDAEM ERRLRALRAA KANESEEAER RAAEEKAREE 100
    ERARRRAEIE AKEREEQERE ERARQKAEEE EEARKKAEAD ASSKPAAARS 150
    KADDPATMDP AAAQAAEARG AGKTGSGPRK ERTADRAQPR KEQKGKGDDR 200
    RRSGKLTLNQ ALSGDGGRQK SMAAMKRKQE RERRKAMGGS QEREKIVRDV 250
    QLPETIVVQE LANRMAERVA DVVKALMKMG MMVTQNQSID ADTAELIIEE 300
    FGHKVVRVSD ADVEDVIATV EDDPADMQPR PPVITVMGHV DHGKTSLLDA 350
    IRNAKVVAGE AGGITQHIGA YQVTTDDGTK LSFLDTPGHA AFTSMRARGA 400
    QVTDIVVLVV AADDAVMPQT IEAINHAKAA KVPMIVAINK IDRPEANPDK 450
    VRTDLLQHEV IVEKLSGDVQ DVEVSAINGT GLDQLLESIA LQAEILELKA 500
    NPDRAAEGAV IEAQLDVGRG PVATVLVQKG TLRRGDIFVV GEQWGKVRAL 550
    INDQGERVDE AGPSVPVEVL GLNGTPEAGD VLNVVETEAQ AREIAEYRES 600
    AAKEKRAAAG AATTLEQLMA KAKSDETVAE LPIVVKADVQ GSAEAIVQTM 650
    EKIGNEEVRV RVLHSGVGAI TESDIGLAEA SGAPVFGFNV RANAPARNAA 700
    QQKGVEIRYY SIIYDLVDDV KAAASGLLSA EVRENFIGYA EIREVFKVSG 750
    VGKVAGCLVT DGIARRSAGV RLLRDNVVIH EGTLKTLKRF KDEVKEVQSG 800
    QECGMAFENY DDIRPGDVIE IFEREEVERN LE 832
    Length:832
    Mass (Da):89,918
    Last modified:December 4, 2007 - v1
    Checksum:iD82A655A1AA34A03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV95296.1.
    RefSeqiWP_012180219.1. NC_009952.1.
    YP_001534897.1. NC_009952.1.

    Genome annotation databases

    EnsemblBacteriaiABV95296; ABV95296; Dshi_3563.
    GeneIDi5713794.
    KEGGidsh:Dshi_3563.
    PATRICi21819939. VBIDinShi9476_3698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV95296.1 .
    RefSeqi WP_012180219.1. NC_009952.1.
    YP_001534897.1. NC_009952.1.

    3D structure databases

    ProteinModelPortali A8LQ56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398580.Dshi_3563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV95296 ; ABV95296 ; Dshi_3563 .
    GeneIDi 5713794.
    KEGGi dsh:Dshi_3563.
    PATRICi 21819939. VBIDinShi9476_3698.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi HKITDVI.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci DSHI398580:GKEL-3603-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16493 / NCIMB 14021 / DFL 12.

    Entry informationi

    Entry nameiIF2_DINSH
    AccessioniPrimary (citable) accession number: A8LQ56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3