A8LPZ1 (A8LPZ1_DINSH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ferrochelatase HAMAP MF_00323
EC=4.99.1.1 HAMAP MF_00323

Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323

Gene names

Name:	hemH HAMAP MF_00323 EMBL ABV95231.1
Ordered Locus Names:	Dshi_3498

Organism

Dinoroseobacter shibae (strain DFL 12) [Complete proteome] [HAMAP]

Taxonomic identifier

398580 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Dinoroseobacter

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 SAAS SAAS001015
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 SAAS SAAS001015
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Ontologies

Keywords
Biological process	Heme biosynthesis HAMAP MF_00323 SAAS SAAS001015 Porphyrin biosynthesis HAMAP MF_00323 SAAS SAAS001015
Cellular component	Cytoplasm HAMAP MF_00323
Ligand	Iron HAMAP MF_00323 SAAS SAAS001015 Metal-binding HAMAP MF_00323
Molecular function	Lyase HAMAP MF_00323 SAAS SAAS001015 EMBL ABV95231.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	228	1	Iron By similarity HAMAP MF_00323
	Metal binding	309	1	Iron By similarity HAMAP MF_00323

Sequences

	Sequence		Length	Mass (Da)
	A8LPZ1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 15C2A24EAD9DA8ED	FASTA	362	41,096
	10 20 30 40 50 60 MADRGTEPMN MMSKTTSSHL PGDHPPVNFG KVGVLLANLG TPDNYDYWSM RRYLNEFLSD 70 80 90 100 110 120 KRVIDYSPWI WQPLLQLVIL TKRPFSSGAA YKSIWNEEAG ESPLMTITKD QTAKMKAAMQ 130 140 150 160 170 180 ARFGDDVVVD FCMRYGNPST KSKVEELQKQ GCQKILFFPL YPQYAGATSA TACDQFFRSL 190 200 210 220 230 240 EHIKWQPIVR TVEPYFEHPM YIEALAQSVE RAYADMETRP DVLVASYHGV PKRYLMEGDP 250 260 270 280 290 300 YHCQCQKTSR LLKERLGWPE GEIVTTFQSR FGPEEWLKPY TVEEVARLAE TGKKKIAVIA 310 320 330 340 350 360 PAFSADCIET LEEINEEIKE SFEEAGGEEF TYIPCLNDDD AHIAALAKVV EENLAGWIAP KG

References

[1]

"The complete genome sequence of the algal symbiont Dinoroseobacter shibae: a hitchhiker's guide to life in the sea." Wagner-Dobler I., Ballhausen B., Berger M., Brinkhoff T., Buchholz I., Bunk B., Cypionka H., Daniel R., Drepper T., Gerdts G., Hahnke S., Han C., Jahn D., Kalhoefer D., Kiss H., Klenk H.P., Kyrpides N., Liebl W. , Liesegang H., Meincke L., Pati A., Petersen J., Piekarski T., Pommerenke C., Pradella S., Pukall R., Rabus R., Stackebrandt E., Thole S., Thompson L., Tielen P., Tomasch J., von Jan M., Wanphrut N., Wichels A., Zech H., Simon M. ISME J. 4:61-77(2010) [PubMed: 19741735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DFL 12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000830 Genomic DNA. Translation: ABV95231.1.
RefSeq	YP_001534832.1. NC_009952.1.
3D structure databases
ProteinModelPortal	A8LPZ1.
ModBase	Search...
Protein-protein interaction databases
STRING	A8LPZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5713729.
GenomeReviews	Gene locus Dshi_3498 in contig CP000830_GR.
KEGG	dsh:Dshi_3498.
PATRIC	21819807. VBIDinShi9476_3632.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697135.
OMA	TIEEIGM.
ProtClustDB	PRK00035.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8LPZ1_DINSH

Accession

Primary (citable) accession number: A8LPZ1

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)