A8LP53 (XYLA_DINSH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	Dshi_1996

Organism

Dinoroseobacter shibae (strain DFL 12) [Complete proteome] [HAMAP]

Taxonomic identifier

398580 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Dinoroseobacter

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Xylose isomerase HAMAP MF_00455		PRO_1000081028
Sites
	Active site	99	1	By similarity
	Active site	102	1	By similarity
	Metal binding	230	1	Magnesium 1 By similarity
	Metal binding	266	1	Magnesium 1 By similarity
	Metal binding	266	1	Magnesium 2 By similarity
	Metal binding	269	1	Magnesium 2 By similarity
	Metal binding	294	1	Magnesium 1 By similarity
	Metal binding	305	1	Magnesium 2 By similarity
	Metal binding	307	1	Magnesium 2 By similarity
	Metal binding	337	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8LP53 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 5307085BE466F244	FASTA	434	48,493
	10 20 30 40 50 60 MSDFFAGIPA VTYEGPEARS DFAFRHYNPD EMVMGKRMED QLRFAVAWWH SFAWEGGDPF 70 80 90 100 110 120 GGPTFQRPWF GDTLDHARAK ADAAFEMFRI LNVPFYCFHD ADIRPEGASF AETTANLEAM 130 140 150 160 170 180 VDYLGQKQEA SGKRLLWGTA NLFSHRRYMA GAATNPDPDV FAYAAATIKT CMDATHKLGG 190 200 210 220 230 240 ANYVLWGGRE GYETLLNTDL GREREQAGRM LQMVVDYKHK IGFEGTILLE PKPQEPTKHQ 250 260 270 280 290 300 YDYDVATVFS FLSEFGLQDE VKMNIEQGHA ILAGHSFEHE LALAREFGIL GSIDMNRNDY 310 320 330 340 350 360 QSGWDTDQFP NNIPEVALAY YEILRAGGFD TGGTNFDSKL RRQSLDPADL IAAHVAAMDV 370 380 390 400 410 420 CAAGLKAAAR MLEDGELEQR REDRYAGWRA PSAEAMLNGG KLEDCFAHVM ETGLDPQPVS 430 GGQERLEALV ARYL

References

[1]

"The complete genome sequence of the algal symbiont Dinoroseobacter shibae: a hitchhiker's guide to life in the sea." Wagner-Dobler I., Ballhausen B., Berger M., Brinkhoff T., Buchholz I., Bunk B., Cypionka H., Daniel R., Drepper T., Gerdts G., Hahnke S., Han C., Jahn D., Kalhoefer D., Kiss H., Klenk H.P., Kyrpides N., Liebl W. , Liesegang H., Meincke L., Pati A., Petersen J., Piekarski T., Pommerenke C., Pradella S., Pukall R., Rabus R., Stackebrandt E., Thole S., Thompson L., Tielen P., Tomasch J., von Jan M., Wanphrut N., Wichels A., Zech H., Simon M. ISME J. 4:61-77(2010) [PubMed: 19741735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DFL 12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000830 Genomic DNA. Translation: ABV93735.1.
RefSeq	YP_001533336.1. NC_009952.1.
3D structure databases
ProteinModelPortal	A8LP53.
ModBase	Search...
Protein-protein interaction databases
STRING	A8LP53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5712991.
GenomeReviews	Gene locus Dshi_1996 in contig CP000830_GR.
KEGG	dsh:Dshi_1996.
PATRIC	21816679. VBIDinShi9476_2078.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297199.
OMA	LLGWDTD.
ProtClustDB	PRK05474.
Enzyme and pathway databases
BioCyc	DSHI398580:DSHI_1996-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_DINSH

Accession

Primary (citable) accession number: A8LP53

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program