Skip Header

Contribute Send feedback
Read comments (?) or add your own

A8LP26 (A8LP26_DINSH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL ABV93708.1
Ordered Locus Names:Dshi_1968
OrganismDinoroseobacter shibae (strain DFL 12) [Complete proteome] [HAMAP]
Taxonomic identifier398580 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Dinoroseobacter

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
A8LP26 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: F00C8A310ED59E44

FASTA88599,469
        10         20         30         40         50         60 
MTDTKHDIDP VESQEWQEAI EDVIARDGAD RAHYLLDKAV QQARAAGATL PFSATTPYQN 

        70         80         90        100        110        120 
TIPADDQYDF PGDLEMEWRI RTINRWNAMA TVVRRNKVSS EYGGHIASFA SSAVMYDVGL 

       130        140        150        160        170        180 
NHFWRSKSAI HGGDLVFFQG HVIPGIYARS FMEGRISEEQ LENFRSEVDG SGLSSYPHPW 

       190        200        210        220        230        240 
LMPDYWQFPT VSMGLGPLMA IYQARFMKYM HSRGLIDMAD RKVWCFLGDG EMDEPESRGA 

       250        260        270        280        290        300 
IDLAVREGLD NLIFVINCNL QRLDGPVRGN GKIVQELEGD FRGAGWNVIK LLWGKGWDEL 

       310        320        330        340        350        360 
LEKDVSGRLR QLMDETVDGD YQTFKSKDGA YIRKHFFGKY PETAALVEDW TDEQIWALRR 

       370        380        390        400        410        420 
GGHDPQKVYT AFKKATETKG QPSCLLVKTV KGHGMGTAGE GQNTTHQQKK MNEEQLRAFR 

       430        440        450        460        470        480 
DRFKIPVSDE DVGKAPFVAL NNAQKAYILE RRKELGGEFP KREWRDTPKL EIPALEAFGK 

       490        500        510        520        530        540 
ELKSTGTREI STTMAFVRIL TTLLRDKNIG KQVVPIVPDE SRTFGMEGLF RSVGIYNPMG 

       550        560        570        580        590        600 
QTYIPEDRDQ MSYYKESETG QVLQEGINEA GAMADWIAAA TSYSNHGVPM IPFFIYYSMF 

       610        620        630        640        650        660 
GFQRIGDLAW AAGDSRARGF MLGGTAGRTT LNGEGLQHED GHSHILAGTI PNCISYDPTF 

       670        680        690        700        710        720 
SYEVAVIVHH GLKRMYVEQD DVYFYLTLMN ENYTHPDMPM GVEEDIIKGL YRFSKTAKPN 

       730        740        750        760        770        780 
KKHVNLMGSG TILVQAIKAA EMLKEDFGVT SDIWSATSMN ELARDGQDCA RANRLDPLGD 

       790        800        810        820        830        840 
QKVPFVTQQL EGVTGPVIAA TDYMKNYAEQ IRAFVPQDFT VLGTDGFGRS DSRVNLRRFF 

       850        860        870        880 
EVDSNHIAAA AMVALHRQGT VTDAVLKKAL ARYEIDSNKP NPRLV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000830 Genomic DNA. Translation: ABV93708.1.
RefSeqYP_001533309.1. NC_009952.1.

3D structure databases

ProteinModelPortalA8LP26.
SMRA8LP26. Positions 58-884.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8LP26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5712962.
GenomeReviewsGene locus Dshi_1968 in contig CP000830_GR.
KEGGdsh:Dshi_1968.
PATRIC21816617. VBIDinShi9476_2048.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289271.
OMADRHFVVL.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8LP26_DINSH
AccessionPrimary (citable) accession number: A8LP26
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info