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A8LNB8

- PUR5_DINSH

UniProt

A8LNB8 - PUR5_DINSH

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDSHI398580:GKEL-1920-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:Dshi_1889
    OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
    Taxonomic identifieri398580 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
    ProteomesiUP000006833: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000083457Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398580.Dshi_1889.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LNB8.
    SMRiA8LNB8. Positions 11-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiGEATCEV.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8LNB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTDTPPPKP GLTYAEAGVD IDAGNTLVDR IKPAAKATSR PGVMSGLGGF    50
    GALFDLRAAG YADPVLVAAT DGVGTKLRIA IDTGHVDTIG IDLVAMCVND 100
    LVCQGAEPLL FLDYFATGKL DVAEAATIVE GIARGCATSG CALIGGETAE 150
    MPGMYAKGDF DLAGFAVGAM ERGGALPANV AAGDMILGLA SDGVHSNGYS 200
    LVRRIVERSG LGWGDPAPFE GRTLGAALLT PTRLYVQPAL AAIRAGGVHG 250
    LAHVTGGGLT ENLPRVLPEG LGIEINLGAW ELPPVFRWLA AEGGLDEAEL 300
    LKTFNAGIGM ALIVAPDRAE ALADLLAGAG ERVAVIGHVT EGAGAVHYRG 350
    TLL 353
    Length:353
    Mass (Da):35,828
    Last modified:December 4, 2007 - v1
    Checksum:iC4011C68C0728E88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV93631.1.
    RefSeqiWP_012178561.1. NC_009952.1.
    YP_001533232.1. NC_009952.1.

    Genome annotation databases

    EnsemblBacteriaiABV93631; ABV93631; Dshi_1889.
    GeneIDi5712881.
    KEGGidsh:Dshi_1889.
    PATRICi21816445. VBIDinShi9476_1964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV93631.1 .
    RefSeqi WP_012178561.1. NC_009952.1.
    YP_001533232.1. NC_009952.1.

    3D structure databases

    ProteinModelPortali A8LNB8.
    SMRi A8LNB8. Positions 11-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398580.Dshi_1889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV93631 ; ABV93631 ; Dshi_1889 .
    GeneIDi 5712881.
    KEGGi dsh:Dshi_1889.
    PATRICi 21816445. VBIDinShi9476_1964.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi GEATCEV.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci DSHI398580:GKEL-1920-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16493 / NCIMB 14021 / DFL 12.

    Entry informationi

    Entry nameiPUR5_DINSH
    AccessioniPrimary (citable) accession number: A8LNB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3