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A8LNB8

- PUR5_DINSH

UniProt

A8LNB8 - PUR5_DINSH

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, Dshi_1889
Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-1920-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Dshi_1889
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000083457Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_1889.

Structurei

3D structure databases

ProteinModelPortaliA8LNB8.
SMRiA8LNB8. Positions 11-345.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LNB8-1 [UniParc]FASTAAdd to Basket

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MTTDTPPPKP GLTYAEAGVD IDAGNTLVDR IKPAAKATSR PGVMSGLGGF    50
GALFDLRAAG YADPVLVAAT DGVGTKLRIA IDTGHVDTIG IDLVAMCVND 100
LVCQGAEPLL FLDYFATGKL DVAEAATIVE GIARGCATSG CALIGGETAE 150
MPGMYAKGDF DLAGFAVGAM ERGGALPANV AAGDMILGLA SDGVHSNGYS 200
LVRRIVERSG LGWGDPAPFE GRTLGAALLT PTRLYVQPAL AAIRAGGVHG 250
LAHVTGGGLT ENLPRVLPEG LGIEINLGAW ELPPVFRWLA AEGGLDEAEL 300
LKTFNAGIGM ALIVAPDRAE ALADLLAGAG ERVAVIGHVT EGAGAVHYRG 350
TLL 353
Length:353
Mass (Da):35,828
Last modified:December 4, 2007 - v1
Checksum:iC4011C68C0728E88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV93631.1.
RefSeqiWP_012178561.1. NC_009952.1.
YP_001533232.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV93631; ABV93631; Dshi_1889.
GeneIDi5712881.
KEGGidsh:Dshi_1889.
PATRICi21816445. VBIDinShi9476_1964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV93631.1 .
RefSeqi WP_012178561.1. NC_009952.1.
YP_001533232.1. NC_009952.1.

3D structure databases

ProteinModelPortali A8LNB8.
SMRi A8LNB8. Positions 11-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_1889.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV93631 ; ABV93631 ; Dshi_1889 .
GeneIDi 5712881.
KEGGi dsh:Dshi_1889.
PATRICi 21816445. VBIDinShi9476_1964.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci DSHI398580:GKEL-1920-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiPUR5_DINSH
AccessioniPrimary (citable) accession number: A8LNB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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