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A8LMD0 (PUR9_DINSH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Dshi_0358
OrganismDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12) [Complete proteome] [HAMAP]
Taxonomic identifier398580 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000076480

Sequences

Sequence LengthMass (Da)Tools
A8LMD0 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 9D80F746B4C28997

FASTA52955,301
        10         20         30         40         50         60 
MTDLVPLRRA LLSVSDKTGL VPLGQALAAR GVELLSTGGT AKALREAGLD VVDVSDVTGF 

        70         80         90        100        110        120 
PEMMDGRVKT LHPKVHGGLL ALRDNAAHVS AMERHGIGAI DLLVVNLYPF EATVAAGADY 

       130        140        150        160        170        180 
AACIENIDIG GPAMIRAAAK NHSFVTVLTD VEDYEALLGE LEAREGATGY PFRQKMALNA 

       190        200        210        220        230        240 
YARTAAYDAA VSGWMTDALA EVAPRRRAVA GTLAQTLRYG ENPHQGAAFY VDGSDRPGVA 

       250        260        270        280        290        300 
TAVQHQGKEL SYNNINDTDA AFELVAEFAP EDGPACAIIK HANPCGVARG ATLAEAYTKA 

       310        320        330        340        350        360 
FQCDQTSAFG GIIALNRPLD GPTAEAISGI FTEVVIAPGA DETARAVFAA KKNLRLLTTE 

       370        380        390        400        410        420 
GLPDPKAPAL TVRQVSGGYL VQDKDNGNIG WDDLKVVTKR APSEAEIADL LFAWKVAKHV 

       430        440        450        460        470        480 
KSNAIVYVKD GATVGVGAGQ MSRVDSARIA ARKSADMAEA LGLETPLIQG SVVASDAFFP 

       490        500        510        520 
FPDGLLTAAE AGATAVIQPG GSMRDVEVIA AADAAGLAMV FTGMRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000830 Genomic DNA. Translation: ABV92107.1.
RefSeqYP_001531708.1. NC_009952.1.

3D structure databases

ProteinModelPortalA8LMD0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398580.Dshi_0358.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV92107; ABV92107; Dshi_0358.
GeneID5711267.
KEGGdsh:Dshi_0358.
PATRIC21813179. VBIDinShi9476_0362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycDSHI398580:GKEL-360-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_DINSH
AccessionPrimary (citable) accession number: A8LMD0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: March 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways