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A8LMD0

- PUR9_DINSH

UniProt

A8LMD0 - PUR9_DINSH

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciDSHI398580:GKEL-360-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Dshi_0358
    OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
    Taxonomic identifieri398580 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
    ProteomesiUP000006833: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000076480Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398580.Dshi_0358.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LMD0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiCGVATGP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8LMD0-1 [UniParc]FASTAAdd to Basket

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    MTDLVPLRRA LLSVSDKTGL VPLGQALAAR GVELLSTGGT AKALREAGLD    50
    VVDVSDVTGF PEMMDGRVKT LHPKVHGGLL ALRDNAAHVS AMERHGIGAI 100
    DLLVVNLYPF EATVAAGADY AACIENIDIG GPAMIRAAAK NHSFVTVLTD 150
    VEDYEALLGE LEAREGATGY PFRQKMALNA YARTAAYDAA VSGWMTDALA 200
    EVAPRRRAVA GTLAQTLRYG ENPHQGAAFY VDGSDRPGVA TAVQHQGKEL 250
    SYNNINDTDA AFELVAEFAP EDGPACAIIK HANPCGVARG ATLAEAYTKA 300
    FQCDQTSAFG GIIALNRPLD GPTAEAISGI FTEVVIAPGA DETARAVFAA 350
    KKNLRLLTTE GLPDPKAPAL TVRQVSGGYL VQDKDNGNIG WDDLKVVTKR 400
    APSEAEIADL LFAWKVAKHV KSNAIVYVKD GATVGVGAGQ MSRVDSARIA 450
    ARKSADMAEA LGLETPLIQG SVVASDAFFP FPDGLLTAAE AGATAVIQPG 500
    GSMRDVEVIA AADAAGLAMV FTGMRHFRH 529
    Length:529
    Mass (Da):55,301
    Last modified:December 4, 2007 - v1
    Checksum:i9D80F746B4C28997
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV92107.1.
    RefSeqiYP_001531708.1. NC_009952.1.

    Genome annotation databases

    EnsemblBacteriaiABV92107; ABV92107; Dshi_0358.
    GeneIDi5711267.
    KEGGidsh:Dshi_0358.
    PATRICi21813179. VBIDinShi9476_0362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV92107.1 .
    RefSeqi YP_001531708.1. NC_009952.1.

    3D structure databases

    ProteinModelPortali A8LMD0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398580.Dshi_0358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV92107 ; ABV92107 ; Dshi_0358 .
    GeneIDi 5711267.
    KEGGi dsh:Dshi_0358.
    PATRICi 21813179. VBIDinShi9476_0362.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi CGVATGP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci DSHI398580:GKEL-360-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16493 / NCIMB 14021 / DFL 12.

    Entry informationi

    Entry nameiPUR9_DINSH
    AccessioniPrimary (citable) accession number: A8LMD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3