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A8LLT4 (FABH_DINSH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:Dshi_1720
OrganismDinoroseobacter shibae (strain DFL 12) [Complete proteome] [HAMAP]
Taxonomic identifier398580 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Dinoroseobacter

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3243243-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000088311

Regions

Region252 – 2565ACP-binding By similarity

Sites

Active site1141 By similarity
Active site2511 By similarity
Active site2811 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8LLT4 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 605DA67CB3774A66

FASTA32434,039
        10         20         30         40         50         60 
MGKRAVVTGV GHYLPSRVVP NSELETLVDT TDEWIRTRSG IERRHFAADG EQTSDLATAA 

        70         80         90        100        110        120 
AQAALDHAEL TAQDVDAVIV ATSTPDLTFP AVATMVQARL GMTRGFAYDV QAVCAGFVFA 

       130        140        150        160        170        180 
MANANAMILS GQADRILVIG AETFSRIMDW TDRSTCVLFG DGAGAVVLEA RDGTGGTADR 

       190        200        210        220        230        240 
GILSADLNSD GRHRDILYVD GGVSSSQTAG YLRMEGKEVF RHAIEKLAAT AETALAKAGL 

       250        260        270        280        290        300 
TEADVDWVVP HQANLRIITA TARKMGIGMD RVVVTVADHG NTSAASIPMA LSVGVARGQI 

       310        320 
KPGDLVVTEA IGGGLSWGSV VLRW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000830 Genomic DNA. Translation: ABV93462.1.
RefSeqYP_001533063.1. NC_009952.1.

3D structure databases

ProteinModelPortalA8LLT4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8LLT4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5713286.
GenomeReviewsGene locus Dshi_1720 in contig CP000830_GR.
KEGGdsh:Dshi_1720.
PATRIC21816075. VBIDinShi9476_1786.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAQANTRIV.
ProtClustDBCLSK933877.

Enzyme and pathway databases

BioCycDSHI398580:DSHI_1720-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_DINSH
AccessionPrimary (citable) accession number: A8LLT4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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