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Protein

Pantothenate synthetase

Gene

panC

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton donorUniRule annotation1
Binding sitei62Beta-alanineUniRule annotation1
Binding sitei62PantoateUniRule annotation1
Binding sitei154PantoateUniRule annotation1
Binding sitei177ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8
Nucleotide bindingi148 – 151ATPUniRule annotation4
Nucleotide bindingi185 – 188ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Dshi_2952
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
Proteomesi
  • UP000006833 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000768541 – 281Pantothenate synthetaseAdd BLAST281

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi398580.Dshi_2952.

Structurei

3D structure databases

ProteinModelPortaliA8LKA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R03. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175516.
KOiK01918.
OMAiNIEMQIE.
OrthoDBiPOG091H00FM.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LKA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVMRDVAS LRMLQGMWRR AGETVGLVPT MGALHDGHMA LARAAREECG
60 70 80 90 100
KVIATIFVNP TQFGPTEDLD AYPNTFDSDL HMLREVGVDV VFAPTRDVMY
110 120 130 140 150
PAGFGTTVKV AGLTAPLCGA ARPGHFDGVT QVVAKLLNLG QADRAYFGQK
160 170 180 190 200
DWQQLAVVRQ MVRDLNFPTE IVGIPTVRAE DGLALSSRNA YLTEAEREIA
210 220 230 240 250
PILYRTIRDA AARVAAGHGA TGVCEAAARG LLGKGFTRID YLECRDATTL
260 270 280
APAETPDPGT ARIFVAAQLG GARLIDNVSV G
Length:281
Mass (Da):30,054
Last modified:December 4, 2007 - v1
Checksum:i014F4FAD89A6693E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000830 Genomic DNA. Translation: ABV94685.1.
RefSeqiWP_012179613.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV94685; ABV94685; Dshi_2952.
KEGGidsh:Dshi_2952.
PATRICi21818687. VBIDinShi9476_3075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000830 Genomic DNA. Translation: ABV94685.1.
RefSeqiWP_012179613.1. NC_009952.1.

3D structure databases

ProteinModelPortaliA8LKA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398580.Dshi_2952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV94685; ABV94685; Dshi_2952.
KEGGidsh:Dshi_2952.
PATRICi21818687. VBIDinShi9476_3075.

Phylogenomic databases

eggNOGiENOG4107R03. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175516.
KOiK01918.
OMAiNIEMQIE.
OrthoDBiPOG091H00FM.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANC_DINSH
AccessioniPrimary (citable) accession number: A8LKA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.