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A8LJY0

- SYL_DINSH

UniProt

A8LJY0 - SYL_DINSH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-55-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Dshi_0057
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Leucine--tRNA ligasePRO_0000334751Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_0057.

Structurei

3D structure databases

ProteinModelPortaliA8LJY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionAdd
BLAST
Motifi636 – 6405"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LJY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPADTPAGSA PARFDPAQIE PKWRAAWDLA GTFTATPDPA KQKYYVLEMF
60 70 80 90 100
PYPSGRIHMG HVRNYTMGDV IARYKASCGF SVLHPMGWDA FGMPAENAAM
110 120 130 140 150
ATGGHPKDWT YANIAEMRAQ MKPLGLSIDW SREFATCDEA YYGQQQSMFL
160 170 180 190 200
DFLEKGLVYR KNAVVNWDPV DMTVLANEQV IDGKGWRSGA EVERRELTQW
210 220 230 240 250
FFKISDFADD LLSALDGLEN WPEKVRLMQA NWIGKSRGLE FAFARTDGGD
260 270 280 290 300
PIPVYTTRPD TLMGASFVGI SPGHPIAKAL AAQRPEVADF LAEVARGGTT
310 320 330 340 350
EAALETAPKL GFDTGITVRH PLDPNWELPV WIANFILMDY GTGAIFACPA
360 370 380 390 400
HDQRDLDFCR KYDLPVIDTF FALDDPTPVG DTAFVPPKTE PVRWVEHFAG
410 420 430 440 450
LDIATGQEAI EATIDFAEAA GWGRGVEQFR LRDWGLSRQR YWGCPIPVVH
460 470 480 490 500
CDKCGVVPER KENLPIALPY DEDGRPIDFS IPGNPLDRHP SWRDCACPAC
510 520 530 540 550
GAPARRETDT MDTFVDSSWY FARFTAPRAE TPTDPAEVGY WMNVDQYIGG
560 570 580 590 600
VEHAILHLLY SRFFARAMHL CGHLPESARE PFDALFTQGM VTHAIYKTTG
610 620 630 640 650
TDGRPVYHYP EEVETTEEGA VLKKTGAPVD IVPSAKMSKS KNNVVDPLAI
660 670 680 690 700
IDAYGADTAR WFVMSDSPPE RDVEWTASGA EAAFKHLGRV WRLAEDLRRN
710 720 730 740 750
AEEAATAGSA EEARALARAS ARAIAEVTAG IEGFAFNKSV AKLYEFTNTI
760 770 780 790 800
QKSKAPRAEK RAALKTMAQL MSPMTPHLAE EVWSMLGGIG LVAEAPWPEA
810 820 830 840 850
DPALLVEDTV TLPIQINGKR RSELAVPKDM PREEVEKLAL ADAAVLKALA
860
GGAPRKLIVV PGRIVNVVI
Length:869
Mass (Da):95,851
Last modified:December 4, 2007 - v1
Checksum:iF28AB5E002CF156F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV91806.1.
RefSeqiWP_012176739.1. NC_009952.1.
YP_001531407.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV91806; ABV91806; Dshi_0057.
GeneIDi5711679.
KEGGidsh:Dshi_0057.
PATRICi21812549. VBIDinShi9476_0051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV91806.1 .
RefSeqi WP_012176739.1. NC_009952.1.
YP_001531407.1. NC_009952.1.

3D structure databases

ProteinModelPortali A8LJY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_0057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV91806 ; ABV91806 ; Dshi_0057 .
GeneIDi 5711679.
KEGGi dsh:Dshi_0057.
PATRICi 21812549. VBIDinShi9476_0051.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DSHI398580:GKEL-55-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiSYL_DINSH
AccessioniPrimary (citable) accession number: A8LJY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3