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A8LJY0

- SYL_DINSH

UniProt

A8LJY0 - SYL_DINSH

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Protein
Leucine--tRNA ligase
Gene
leuS, Dshi_0057
Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-55-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Dshi_0057
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Leucine--tRNA ligaseUniRule annotation
PRO_0000334751Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_0057.

Structurei

3D structure databases

ProteinModelPortaliA8LJY0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionUniRule annotation
Add
BLAST
Motifi636 – 6405"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LJY0-1 [UniParc]FASTAAdd to Basket

« Hide

MPADTPAGSA PARFDPAQIE PKWRAAWDLA GTFTATPDPA KQKYYVLEMF    50
PYPSGRIHMG HVRNYTMGDV IARYKASCGF SVLHPMGWDA FGMPAENAAM 100
ATGGHPKDWT YANIAEMRAQ MKPLGLSIDW SREFATCDEA YYGQQQSMFL 150
DFLEKGLVYR KNAVVNWDPV DMTVLANEQV IDGKGWRSGA EVERRELTQW 200
FFKISDFADD LLSALDGLEN WPEKVRLMQA NWIGKSRGLE FAFARTDGGD 250
PIPVYTTRPD TLMGASFVGI SPGHPIAKAL AAQRPEVADF LAEVARGGTT 300
EAALETAPKL GFDTGITVRH PLDPNWELPV WIANFILMDY GTGAIFACPA 350
HDQRDLDFCR KYDLPVIDTF FALDDPTPVG DTAFVPPKTE PVRWVEHFAG 400
LDIATGQEAI EATIDFAEAA GWGRGVEQFR LRDWGLSRQR YWGCPIPVVH 450
CDKCGVVPER KENLPIALPY DEDGRPIDFS IPGNPLDRHP SWRDCACPAC 500
GAPARRETDT MDTFVDSSWY FARFTAPRAE TPTDPAEVGY WMNVDQYIGG 550
VEHAILHLLY SRFFARAMHL CGHLPESARE PFDALFTQGM VTHAIYKTTG 600
TDGRPVYHYP EEVETTEEGA VLKKTGAPVD IVPSAKMSKS KNNVVDPLAI 650
IDAYGADTAR WFVMSDSPPE RDVEWTASGA EAAFKHLGRV WRLAEDLRRN 700
AEEAATAGSA EEARALARAS ARAIAEVTAG IEGFAFNKSV AKLYEFTNTI 750
QKSKAPRAEK RAALKTMAQL MSPMTPHLAE EVWSMLGGIG LVAEAPWPEA 800
DPALLVEDTV TLPIQINGKR RSELAVPKDM PREEVEKLAL ADAAVLKALA 850
GGAPRKLIVV PGRIVNVVI 869
Length:869
Mass (Da):95,851
Last modified:December 4, 2007 - v1
Checksum:iF28AB5E002CF156F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV91806.1.
RefSeqiWP_012176739.1. NC_009952.1.
YP_001531407.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV91806; ABV91806; Dshi_0057.
GeneIDi5711679.
KEGGidsh:Dshi_0057.
PATRICi21812549. VBIDinShi9476_0051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV91806.1 .
RefSeqi WP_012176739.1. NC_009952.1.
YP_001531407.1. NC_009952.1.

3D structure databases

ProteinModelPortali A8LJY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_0057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV91806 ; ABV91806 ; Dshi_0057 .
GeneIDi 5711679.
KEGGi dsh:Dshi_0057.
PATRICi 21812549. VBIDinShi9476_0051.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DSHI398580:GKEL-55-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiSYL_DINSH
AccessioniPrimary (citable) accession number: A8LJY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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