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A8LJY0

- SYL_DINSH

UniProt

A8LJY0 - SYL_DINSH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei639 – 6391ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDSHI398580:GKEL-55-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Dshi_0057
    OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
    Taxonomic identifieri398580 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
    ProteomesiUP000006833: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 869869Leucine--tRNA ligasePRO_0000334751Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398580.Dshi_0057.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LJY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 6111"HIGH" regionAdd
    BLAST
    Motifi636 – 6405"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8LJY0-1 [UniParc]FASTAAdd to Basket

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    MPADTPAGSA PARFDPAQIE PKWRAAWDLA GTFTATPDPA KQKYYVLEMF    50
    PYPSGRIHMG HVRNYTMGDV IARYKASCGF SVLHPMGWDA FGMPAENAAM 100
    ATGGHPKDWT YANIAEMRAQ MKPLGLSIDW SREFATCDEA YYGQQQSMFL 150
    DFLEKGLVYR KNAVVNWDPV DMTVLANEQV IDGKGWRSGA EVERRELTQW 200
    FFKISDFADD LLSALDGLEN WPEKVRLMQA NWIGKSRGLE FAFARTDGGD 250
    PIPVYTTRPD TLMGASFVGI SPGHPIAKAL AAQRPEVADF LAEVARGGTT 300
    EAALETAPKL GFDTGITVRH PLDPNWELPV WIANFILMDY GTGAIFACPA 350
    HDQRDLDFCR KYDLPVIDTF FALDDPTPVG DTAFVPPKTE PVRWVEHFAG 400
    LDIATGQEAI EATIDFAEAA GWGRGVEQFR LRDWGLSRQR YWGCPIPVVH 450
    CDKCGVVPER KENLPIALPY DEDGRPIDFS IPGNPLDRHP SWRDCACPAC 500
    GAPARRETDT MDTFVDSSWY FARFTAPRAE TPTDPAEVGY WMNVDQYIGG 550
    VEHAILHLLY SRFFARAMHL CGHLPESARE PFDALFTQGM VTHAIYKTTG 600
    TDGRPVYHYP EEVETTEEGA VLKKTGAPVD IVPSAKMSKS KNNVVDPLAI 650
    IDAYGADTAR WFVMSDSPPE RDVEWTASGA EAAFKHLGRV WRLAEDLRRN 700
    AEEAATAGSA EEARALARAS ARAIAEVTAG IEGFAFNKSV AKLYEFTNTI 750
    QKSKAPRAEK RAALKTMAQL MSPMTPHLAE EVWSMLGGIG LVAEAPWPEA 800
    DPALLVEDTV TLPIQINGKR RSELAVPKDM PREEVEKLAL ADAAVLKALA 850
    GGAPRKLIVV PGRIVNVVI 869
    Length:869
    Mass (Da):95,851
    Last modified:December 4, 2007 - v1
    Checksum:iF28AB5E002CF156F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV91806.1.
    RefSeqiWP_012176739.1. NC_009952.1.
    YP_001531407.1. NC_009952.1.

    Genome annotation databases

    EnsemblBacteriaiABV91806; ABV91806; Dshi_0057.
    GeneIDi5711679.
    KEGGidsh:Dshi_0057.
    PATRICi21812549. VBIDinShi9476_0051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV91806.1 .
    RefSeqi WP_012176739.1. NC_009952.1.
    YP_001531407.1. NC_009952.1.

    3D structure databases

    ProteinModelPortali A8LJY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398580.Dshi_0057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV91806 ; ABV91806 ; Dshi_0057 .
    GeneIDi 5711679.
    KEGGi dsh:Dshi_0057.
    PATRICi 21812549. VBIDinShi9476_0051.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DSHI398580:GKEL-55-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16493 / NCIMB 14021 / DFL 12.

    Entry informationi

    Entry nameiSYL_DINSH
    AccessioniPrimary (citable) accession number: A8LJY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3