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A8LIR1 (FTHS_DINSH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Dshi_1283
OrganismDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12) [Complete proteome] [HAMAP]
Taxonomic identifier398580 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000333315

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8LIR1 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: B212B3577A56FD19

FASTA55559,106
        10         20         30         40         50         60 
MSDIEIARAA TKKPIQQIGA TLGIGADDLL PYGHDKAKVS QSFITSVQDR PNGKLILVTA 

        70         80         90        100        110        120 
INPTPAGEGK TTTTVGLGDG LNRIGKKACV CIREASLGPN FGMKGGAAGG GHAQVIPMED 

       130        140        150        160        170        180 
MNLHFTGDFH AITSAHSLLS AMIDNHIYWG NELEIDIRRV TWRRVVDMND RALRQITASL 

       190        200        210        220        230        240 
GGVANGFPRE AGFDITVASE VMAILCLARD LKDLEQRLGD MIVAYRRDRS PVYCRDIKAE 

       250        260        270        280        290        300 
GAMTVLLKDA MQPNLVQTLE NNPAFVHGGP FANIAHGCNS VIATTTALKL ADFVVTEAGF 

       310        320        330        340        350        360 
GADLGAEKFM NIKCRKAGLA PDCVVLVATV RAMKMNGGVA KADLGAENVA AVQAGCANLG 

       370        380        390        400        410        420 
RHIGNLQGFG VPVVVAINHF VTDTEAEIQA VKDYVAGQGA EAILSRHWEL GSEGSAALAT 

       430        440        450        460        470        480 
RVAEIAESGA SQFSPLYPDA MPLLEKIETI AKRIYHAEKV IADNKIVDQL KLWEEQGYGH 

       490        500        510        520        530        540 
LPICMAKTQY SFSTDPNERG APTGHAIPVR EVRLSAGAGF VVVVCGEIMT MPGLPRVPSA 

       550 
EHIRLNDAGE VEGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000830 Genomic DNA. Translation: ABV93025.1.
RefSeqYP_001532626.1. NC_009952.1.

3D structure databases

ProteinModelPortalA8LIR1.
SMRA8LIR1. Positions 3-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398580.Dshi_1283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV93025; ABV93025; Dshi_1283.
GeneID5711841.
KEGGdsh:Dshi_1283.
PATRIC21815159. VBIDinShi9476_1332.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycDSHI398580:GKEL-1302-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_DINSH
AccessionPrimary (citable) accession number: A8LIR1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways