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A8LIR1

- FTHS_DINSH

UniProt

A8LIR1 - FTHS_DINSH

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Dshi_1283
Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-1302-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Dshi_1283
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000333315Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398580.Dshi_1283.

Structurei

3D structure databases

ProteinModelPortaliA8LIR1.
SMRiA8LIR1. Positions 3-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LIR1-1 [UniParc]FASTAAdd to Basket

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MSDIEIARAA TKKPIQQIGA TLGIGADDLL PYGHDKAKVS QSFITSVQDR    50
PNGKLILVTA INPTPAGEGK TTTTVGLGDG LNRIGKKACV CIREASLGPN 100
FGMKGGAAGG GHAQVIPMED MNLHFTGDFH AITSAHSLLS AMIDNHIYWG 150
NELEIDIRRV TWRRVVDMND RALRQITASL GGVANGFPRE AGFDITVASE 200
VMAILCLARD LKDLEQRLGD MIVAYRRDRS PVYCRDIKAE GAMTVLLKDA 250
MQPNLVQTLE NNPAFVHGGP FANIAHGCNS VIATTTALKL ADFVVTEAGF 300
GADLGAEKFM NIKCRKAGLA PDCVVLVATV RAMKMNGGVA KADLGAENVA 350
AVQAGCANLG RHIGNLQGFG VPVVVAINHF VTDTEAEIQA VKDYVAGQGA 400
EAILSRHWEL GSEGSAALAT RVAEIAESGA SQFSPLYPDA MPLLEKIETI 450
AKRIYHAEKV IADNKIVDQL KLWEEQGYGH LPICMAKTQY SFSTDPNERG 500
APTGHAIPVR EVRLSAGAGF VVVVCGEIMT MPGLPRVPSA EHIRLNDAGE 550
VEGLF 555
Length:555
Mass (Da):59,106
Last modified:December 4, 2007 - v1
Checksum:iB212B3577A56FD19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV93025.1.
RefSeqiWP_012177955.1. NC_009952.1.
YP_001532626.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV93025; ABV93025; Dshi_1283.
GeneIDi5711841.
KEGGidsh:Dshi_1283.
PATRICi21815159. VBIDinShi9476_1332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV93025.1 .
RefSeqi WP_012177955.1. NC_009952.1.
YP_001532626.1. NC_009952.1.

3D structure databases

ProteinModelPortali A8LIR1.
SMRi A8LIR1. Positions 3-553.
ModBasei Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_1283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV93025 ; ABV93025 ; Dshi_1283 .
GeneIDi 5711841.
KEGGi dsh:Dshi_1283.
PATRICi 21815159. VBIDinShi9476_1332.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DSHI398580:GKEL-1302-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiFTHS_DINSH
AccessioniPrimary (citable) accession number: A8LIR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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