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A8LIP0

- SYE2_DINSH

UniProt

A8LIP0 - SYE2_DINSH

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Protein
Glutamate--tRNA ligase 2
Gene
gltX2, Dshi_2748
Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-2786-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2 (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase 2
Short name:
GluRS 2
Gene namesi
Name:gltX2
Ordered Locus Names:Dshi_2748
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Glutamate--tRNA ligase 2UniRule annotation
PRO_0000367666Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi398580.Dshi_2748.

Structurei

3D structure databases

ProteinModelPortaliA8LIP0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi8 – 1811"HIGH" regionUniRule annotation
Add
BLAST
Motifi239 – 2435"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252721.
KOiK01885.
OMAiGHIYACY.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LIP0-1 [UniParc]FASTAAdd to Basket

« Hide

MTTTRFAPSP TGYLHVGNLR TALFNYMIAR KAGGTFILRI DDTDPERSKP    50
EYVDAIQEDL TWLGLTWDRI EYQSRRLDRY AEAADALRAA GRFYEAFETP 100
TELDLKRKKQ LNMGRPPVYD RAALALSEDE KAALRAERGQ GVWRFKLDHE 150
RITWTDGILG DISIDAASVS DPVLIRGDGQ VLYTIASVVD DTEMGVTHVV 200
RGSDHVTNTA TQIQIMAALG HGHPEFAHHS LLTGPQGEAL SKRLGTLALR 250
DLRAEGIEPM ALLSLMARLG SSQPVEVAGS LEALIEGFDL STFGAAPTKF 300
DRADLFPLTA RLLHATPFAE VADEIAALGV PAAQAELFWE VARANITTRA 350
DLAGWWQLFR DGGAPLVAEE DRAFVADAFA RLPEPPYGPE TWGAWTAEVK 400
AASGRKGKGL FMPLRKAVTG LERGPEMADV MRLLQKKPTL 440
Length:440
Mass (Da):48,289
Last modified:December 4, 2007 - v1
Checksum:i1711E9B9F83B7C2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV94481.1.
RefSeqiYP_001534082.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV94481; ABV94481; Dshi_2748.
GeneIDi5713647.
KEGGidsh:Dshi_2748.
PATRICi21818261. VBIDinShi9476_2862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV94481.1 .
RefSeqi YP_001534082.1. NC_009952.1.

3D structure databases

ProteinModelPortali A8LIP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_2748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV94481 ; ABV94481 ; Dshi_2748 .
GeneIDi 5713647.
KEGGi dsh:Dshi_2748.
PATRICi 21818261. VBIDinShi9476_2862.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252721.
KOi K01885.
OMAi GHIYACY.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci DSHI398580:GKEL-2786-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiSYE2_DINSH
AccessioniPrimary (citable) accession number: A8LIP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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