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A8LIH2

- GCSP_DINSH

UniProt

A8LIH2 - GCSP_DINSH

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDSHI398580:GKEL-2717-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Dshi_2680
    OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
    Taxonomic identifieri398580 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
    ProteomesiUP000006833: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000083205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei700 – 7001N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi398580.Dshi_2680.

    Structurei

    3D structure databases

    ProteinModelPortaliA8LIH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8LIH2-1 [UniParc]FASTAAdd to Basket

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    MGFSLTDYAP YDFANRRHIG PSPKEMGQML ATLGVPSLEA LINEALPEGI    50
    RRRDPLAFGP ALSERDTLHR MRELADKNTV LTSLIGQGYH GTHTPPVILR 100
    NILENPAWYT AYTPYQPEIS QGRLEALLNF QTMMADLTGL PIANASLLDE 150
    GTAAAEAMAM AQRASKSKAR GFFVAEDCHP QTIDVIRTRA EPLGIEVIVG 200
    AVDALDPEAV FAALFQYPGS YGHVRDYSDV IEALHGARAL AVVAADPLAL 250
    TLLKSPGEMG ADIAIGSTQR FGVPMGYGGP HAAYMTCTDA LKRSMPGRII 300
    GVSVDARGNK AYRLSLQTRE QHIRREKANS NVCTAQALLA VMASMYGVFH 350
    GPDGLKAIAQ TVHRKTARMA DGLTELGFKV DPQDYFDTIT VKVGSMQGVI 400
    LAAALREGVN LRKVGTDRIG ITLDELTLGR TIEAVWRAFG AEGMVYDKTR 450
    MVYHLPQEML RESSYMTHPI FHMNRAEAEM TRYMRRLADR DLALDRAMIP 500
    LGSCTMKLNA TVEMLPLTWP EFANLHPFAP ADQAAGYHEM IAELSQMLCD 550
    VTGYDAMSMQ PNSGAQGEYA GLLAIRGYHR ARGEGHRNIC LIPTSAHGTN 600
    PASAQMVGWK VVVVKSAENG DIDLEDFRAK AEQHSENLAG CMITYPSTHG 650
    VFEEIVREVC DITHAHGGQV YIDGANMNAM VGLSAPGDLG GDVSHLNLHK 700
    TFCIPHGGGG PGMGPIGVKA HLAPHLPSHA TATGAGFGDA GAVASAAYGS 750
    PSILTISYAY CLLMGGAGLT QATKVAILNA NYMAKRLSAG FPILYANDKG 800
    RVAHECILDT RVLDKIAGVT VEDVAKRLMD CGFHAPTMSW PVAGTLMVEP 850
    TESEPKAELD RFCDAMLAIR EEADAIAAGS LDAENNPLKR APHTVEDLVG 900
    DWDRPYSREQ ACYPPGAFRV DKYWPPVNRV DNAYGDRNLV CTCPPVEDYA 950
    EPAE 954
    Length:954
    Mass (Da):103,117
    Last modified:December 4, 2007 - v1
    Checksum:i1603D6202E390F42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV94413.1.
    RefSeqiWP_012179341.1. NC_009952.1.
    YP_001534014.1. NC_009952.1.

    Genome annotation databases

    EnsemblBacteriaiABV94413; ABV94413; Dshi_2680.
    GeneIDi5713578.
    KEGGidsh:Dshi_2680.
    PATRICi21818109. VBIDinShi9476_2787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000830 Genomic DNA. Translation: ABV94413.1 .
    RefSeqi WP_012179341.1. NC_009952.1.
    YP_001534014.1. NC_009952.1.

    3D structure databases

    ProteinModelPortali A8LIH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398580.Dshi_2680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV94413 ; ABV94413 ; Dshi_2680 .
    GeneIDi 5713578.
    KEGGi dsh:Dshi_2680.
    PATRICi 21818109. VBIDinShi9476_2787.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci DSHI398580:GKEL-2717-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16493 / NCIMB 14021 / DFL 12.

    Entry informationi

    Entry nameiGCSP_DINSH
    AccessioniPrimary (citable) accession number: A8LIH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3