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A8LIH2 (GCSP_DINSH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Dshi_2680
OrganismDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12) [Complete proteome] [HAMAP]
Taxonomic identifier398580 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000083205

Amino acid modifications

Modified residue7001N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8LIH2 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 1603D6202E390F42

FASTA954103,117
        10         20         30         40         50         60 
MGFSLTDYAP YDFANRRHIG PSPKEMGQML ATLGVPSLEA LINEALPEGI RRRDPLAFGP 

        70         80         90        100        110        120 
ALSERDTLHR MRELADKNTV LTSLIGQGYH GTHTPPVILR NILENPAWYT AYTPYQPEIS 

       130        140        150        160        170        180 
QGRLEALLNF QTMMADLTGL PIANASLLDE GTAAAEAMAM AQRASKSKAR GFFVAEDCHP 

       190        200        210        220        230        240 
QTIDVIRTRA EPLGIEVIVG AVDALDPEAV FAALFQYPGS YGHVRDYSDV IEALHGARAL 

       250        260        270        280        290        300 
AVVAADPLAL TLLKSPGEMG ADIAIGSTQR FGVPMGYGGP HAAYMTCTDA LKRSMPGRII 

       310        320        330        340        350        360 
GVSVDARGNK AYRLSLQTRE QHIRREKANS NVCTAQALLA VMASMYGVFH GPDGLKAIAQ 

       370        380        390        400        410        420 
TVHRKTARMA DGLTELGFKV DPQDYFDTIT VKVGSMQGVI LAAALREGVN LRKVGTDRIG 

       430        440        450        460        470        480 
ITLDELTLGR TIEAVWRAFG AEGMVYDKTR MVYHLPQEML RESSYMTHPI FHMNRAEAEM 

       490        500        510        520        530        540 
TRYMRRLADR DLALDRAMIP LGSCTMKLNA TVEMLPLTWP EFANLHPFAP ADQAAGYHEM 

       550        560        570        580        590        600 
IAELSQMLCD VTGYDAMSMQ PNSGAQGEYA GLLAIRGYHR ARGEGHRNIC LIPTSAHGTN 

       610        620        630        640        650        660 
PASAQMVGWK VVVVKSAENG DIDLEDFRAK AEQHSENLAG CMITYPSTHG VFEEIVREVC 

       670        680        690        700        710        720 
DITHAHGGQV YIDGANMNAM VGLSAPGDLG GDVSHLNLHK TFCIPHGGGG PGMGPIGVKA 

       730        740        750        760        770        780 
HLAPHLPSHA TATGAGFGDA GAVASAAYGS PSILTISYAY CLLMGGAGLT QATKVAILNA 

       790        800        810        820        830        840 
NYMAKRLSAG FPILYANDKG RVAHECILDT RVLDKIAGVT VEDVAKRLMD CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMVEP TESEPKAELD RFCDAMLAIR EEADAIAAGS LDAENNPLKR APHTVEDLVG 

       910        920        930        940        950 
DWDRPYSREQ ACYPPGAFRV DKYWPPVNRV DNAYGDRNLV CTCPPVEDYA EPAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000830 Genomic DNA. Translation: ABV94413.1.
RefSeqYP_001534014.1. NC_009952.1.

3D structure databases

ProteinModelPortalA8LIH2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398580.Dshi_2680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV94413; ABV94413; Dshi_2680.
GeneID5713578.
KEGGdsh:Dshi_2680.
PATRIC21818109. VBIDinShi9476_2787.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycDSHI398580:GKEL-2717-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_DINSH
AccessionPrimary (citable) accession number: A8LIH2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: March 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families