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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciDSHI398580:G1GA2-2732-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Dshi_2680
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
Proteomesi
  • UP000006833 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832051 – 954Glycine dehydrogenase (decarboxylating)Add BLAST954

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei700N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA8LIH2

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi398580.Dshi_2680

Structurei

3D structure databases

ProteinModelPortaliA8LIH2
SMRiA8LIH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A8LIH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSLTDYAP YDFANRRHIG PSPKEMGQML ATLGVPSLEA LINEALPEGI
60 70 80 90 100
RRRDPLAFGP ALSERDTLHR MRELADKNTV LTSLIGQGYH GTHTPPVILR
110 120 130 140 150
NILENPAWYT AYTPYQPEIS QGRLEALLNF QTMMADLTGL PIANASLLDE
160 170 180 190 200
GTAAAEAMAM AQRASKSKAR GFFVAEDCHP QTIDVIRTRA EPLGIEVIVG
210 220 230 240 250
AVDALDPEAV FAALFQYPGS YGHVRDYSDV IEALHGARAL AVVAADPLAL
260 270 280 290 300
TLLKSPGEMG ADIAIGSTQR FGVPMGYGGP HAAYMTCTDA LKRSMPGRII
310 320 330 340 350
GVSVDARGNK AYRLSLQTRE QHIRREKANS NVCTAQALLA VMASMYGVFH
360 370 380 390 400
GPDGLKAIAQ TVHRKTARMA DGLTELGFKV DPQDYFDTIT VKVGSMQGVI
410 420 430 440 450
LAAALREGVN LRKVGTDRIG ITLDELTLGR TIEAVWRAFG AEGMVYDKTR
460 470 480 490 500
MVYHLPQEML RESSYMTHPI FHMNRAEAEM TRYMRRLADR DLALDRAMIP
510 520 530 540 550
LGSCTMKLNA TVEMLPLTWP EFANLHPFAP ADQAAGYHEM IAELSQMLCD
560 570 580 590 600
VTGYDAMSMQ PNSGAQGEYA GLLAIRGYHR ARGEGHRNIC LIPTSAHGTN
610 620 630 640 650
PASAQMVGWK VVVVKSAENG DIDLEDFRAK AEQHSENLAG CMITYPSTHG
660 670 680 690 700
VFEEIVREVC DITHAHGGQV YIDGANMNAM VGLSAPGDLG GDVSHLNLHK
710 720 730 740 750
TFCIPHGGGG PGMGPIGVKA HLAPHLPSHA TATGAGFGDA GAVASAAYGS
760 770 780 790 800
PSILTISYAY CLLMGGAGLT QATKVAILNA NYMAKRLSAG FPILYANDKG
810 820 830 840 850
RVAHECILDT RVLDKIAGVT VEDVAKRLMD CGFHAPTMSW PVAGTLMVEP
860 870 880 890 900
TESEPKAELD RFCDAMLAIR EEADAIAAGS LDAENNPLKR APHTVEDLVG
910 920 930 940 950
DWDRPYSREQ ACYPPGAFRV DKYWPPVNRV DNAYGDRNLV CTCPPVEDYA

EPAE
Length:954
Mass (Da):103,117
Last modified:December 4, 2007 - v1
Checksum:i1603D6202E390F42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000830 Genomic DNA Translation: ABV94413.1
RefSeqiWP_012179341.1, NC_009952.1

Genome annotation databases

EnsemblBacteriaiABV94413; ABV94413; Dshi_2680
KEGGidsh:Dshi_2680

Similar proteinsi

Entry informationi

Entry nameiGCSP_DINSH
AccessioniPrimary (citable) accession number: A8LIH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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