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A8LIH2

- GCSP_DINSH

UniProt

A8LIH2 - GCSP_DINSH

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Dshi_2680
Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDSHI398580:GKEL-2717-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Dshi_2680
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
ProteomesiUP000006833: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000083205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei700 – 7001N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi398580.Dshi_2680.

Structurei

3D structure databases

ProteinModelPortaliA8LIH2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LIH2-1 [UniParc]FASTAAdd to Basket

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MGFSLTDYAP YDFANRRHIG PSPKEMGQML ATLGVPSLEA LINEALPEGI    50
RRRDPLAFGP ALSERDTLHR MRELADKNTV LTSLIGQGYH GTHTPPVILR 100
NILENPAWYT AYTPYQPEIS QGRLEALLNF QTMMADLTGL PIANASLLDE 150
GTAAAEAMAM AQRASKSKAR GFFVAEDCHP QTIDVIRTRA EPLGIEVIVG 200
AVDALDPEAV FAALFQYPGS YGHVRDYSDV IEALHGARAL AVVAADPLAL 250
TLLKSPGEMG ADIAIGSTQR FGVPMGYGGP HAAYMTCTDA LKRSMPGRII 300
GVSVDARGNK AYRLSLQTRE QHIRREKANS NVCTAQALLA VMASMYGVFH 350
GPDGLKAIAQ TVHRKTARMA DGLTELGFKV DPQDYFDTIT VKVGSMQGVI 400
LAAALREGVN LRKVGTDRIG ITLDELTLGR TIEAVWRAFG AEGMVYDKTR 450
MVYHLPQEML RESSYMTHPI FHMNRAEAEM TRYMRRLADR DLALDRAMIP 500
LGSCTMKLNA TVEMLPLTWP EFANLHPFAP ADQAAGYHEM IAELSQMLCD 550
VTGYDAMSMQ PNSGAQGEYA GLLAIRGYHR ARGEGHRNIC LIPTSAHGTN 600
PASAQMVGWK VVVVKSAENG DIDLEDFRAK AEQHSENLAG CMITYPSTHG 650
VFEEIVREVC DITHAHGGQV YIDGANMNAM VGLSAPGDLG GDVSHLNLHK 700
TFCIPHGGGG PGMGPIGVKA HLAPHLPSHA TATGAGFGDA GAVASAAYGS 750
PSILTISYAY CLLMGGAGLT QATKVAILNA NYMAKRLSAG FPILYANDKG 800
RVAHECILDT RVLDKIAGVT VEDVAKRLMD CGFHAPTMSW PVAGTLMVEP 850
TESEPKAELD RFCDAMLAIR EEADAIAAGS LDAENNPLKR APHTVEDLVG 900
DWDRPYSREQ ACYPPGAFRV DKYWPPVNRV DNAYGDRNLV CTCPPVEDYA 950
EPAE 954
Length:954
Mass (Da):103,117
Last modified:December 4, 2007 - v1
Checksum:i1603D6202E390F42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV94413.1.
RefSeqiWP_012179341.1. NC_009952.1.
YP_001534014.1. NC_009952.1.

Genome annotation databases

EnsemblBacteriaiABV94413; ABV94413; Dshi_2680.
GeneIDi5713578.
KEGGidsh:Dshi_2680.
PATRICi21818109. VBIDinShi9476_2787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000830 Genomic DNA. Translation: ABV94413.1 .
RefSeqi WP_012179341.1. NC_009952.1.
YP_001534014.1. NC_009952.1.

3D structure databases

ProteinModelPortali A8LIH2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 398580.Dshi_2680.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV94413 ; ABV94413 ; Dshi_2680 .
GeneIDi 5713578.
KEGGi dsh:Dshi_2680.
PATRICi 21818109. VBIDinShi9476_2787.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci DSHI398580:GKEL-2717-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16493 / NCIMB 14021 / DFL 12.

Entry informationi

Entry nameiGCSP_DINSH
AccessioniPrimary (citable) accession number: A8LIH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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