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Protein

Thymidine kinase

Gene

tdk

Organism
Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi150ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPUniRule annotation8
Nucleotide bindingi90 – 93ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:Dshi_2641Imported
OrganismiDinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)Imported
Taxonomic identifieri398580 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeDinoroseobacter
Proteomesi
  • UP000006833 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi398580.Dshi_2641

Structurei

3D structure databases

ProteinModelPortaliA8LI40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A8LI40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAMAKLYFH YSTMNAGKST ALLQASHNYI ERGMQTHLMT ARLDHRAGEG
60 70 80 90 100
RIGSRIGLSA PADTFGPETD LFDALALRLK GGPCACVFVD EAQFLTEDQV
110 120 130 140 150
WQLARAVDDL NLPVMCYGLR VDFRGKLFPG SAALLALADE MREVRTICHC
160 170 180 190
GRKATMVVRR DAEGRTVTDG AQVQVGGNET YLSLCRRHWR EATGDRPRG
Length:199
Mass (Da):22,033
Last modified:December 4, 2007 - v1
Checksum:i4027863C8B7481BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000830 Genomic DNA Translation: ABV94374.1

Genome annotation databases

EnsemblBacteriaiABV94374; ABV94374; Dshi_2641
KEGGidsh:Dshi_2641

Similar proteinsi

Entry informationi

Entry nameiA8LI40_DINSH
AccessioniPrimary (citable) accession number: A8LI40
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health