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A8LGR0

- HIS4_FRASN

UniProt

A8LGR0 - HIS4_FRASN

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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Proton acceptorUniRule annotation
Active sitei129 – 1291Proton donorUniRule annotation

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
  2. phosphoribosylanthranilate isomerase activity Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
  2. tryptophan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciFSP298653:GHPI-1943-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
Gene namesi
Name:hisAUniRule annotation
Ordered Locus Names:Franean1_1923
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001313: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2452451-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_1000135120Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_1923.

Structurei

3D structure databases

ProteinModelPortaliA8LGR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
K01817.
OMAiQRDYGSD.
OrthoDBiEOG6H1Q3W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01919. hisA-trpF. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LGR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLTLLPAVD VADGLAVRLV QGEAGTETSY GDPREAALAW QRDGAEWIHL
60 70 80 90 100
VDLDAAFGRG SNRDLIAEVV RSVDVAVELS GGIRDDDSLD AALATGAARV
110 120 130 140 150
NIGTAALEDP EWVRKAIDRV GDRIAVGLDV RGTTLAARGW TREGGELYEV
160 170 180 190 200
LARLDADGCA RYVLTDVRRD GTLTGPNVEL LRAVTAATTR PVVASGGVSS
210 220 230 240
LEDLRVIATV PGVEGAIVGK ALYAGAFTLP EALAVAAEVP AAGAP
Length:245
Mass (Da):25,350
Last modified:December 4, 2007 - v1
Checksum:iF72A73E66AC1687A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW11360.1.
RefSeqiWP_020459528.1. NC_009921.1.
YP_001506266.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW11360; ABW11360; Franean1_1923.
GeneIDi5670324.
KEGGifre:Franean1_1923.
PATRICi21936764. VBIFraSp51419_1992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW11360.1 .
RefSeqi WP_020459528.1. NC_009921.1.
YP_001506266.1. NC_009921.1.

3D structure databases

ProteinModelPortali A8LGR0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298653.Franean1_1923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW11360 ; ABW11360 ; Franean1_1923 .
GeneIDi 5670324.
KEGGi fre:Franean1_1923.
PATRICi 21936764. VBIFraSp51419_1992.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
K01817.
OMAi QRDYGSD.
OrthoDBi EOG6H1Q3W.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
BioCyci FSP298653:GHPI-1943-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01919. hisA-trpF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EAN1pec.

Entry informationi

Entry nameiHIS4_FRASN
AccessioniPrimary (citable) accession number: A8LGR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3