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A8LFJ5 (A8LFJ5_FRASN) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:Franean1_1860
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW11298.1
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
A8LFJ5 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: A84B34AD656D166A

FASTA944104,627
        10         20         30         40         50         60 
MAQDTTRKFS VITDGLPSQL PDIDPSETSE WLESLDAVIE ESGRGRARFL MLKLLERARE 

        70         80         90        100        110        120 
KAVGVPGLTS TDFINTIPPE QEPWFPGDEH VERRIRAYIR WNAAIMVSRA NRPEYNVGGH 

       130        140        150        160        170        180 
IATYASSASL YEVGFNHFFR GKDHLTSSPG SDSGDQIFIQ GHASPGIYAR AFLEGRLTEA 

       190        200        210        220        230        240 
QLDAFRREGE PGGLSSYPHP RLMPDFWEFP TVSMGLGPID AIYQARFNRY LLNRQIKDTS 

       250        260        270        280        290        300 
RSKVWAFLGD GEMDEPESIG ALGVAAREEL DNLIFVVNCN LQRLDGPVRG NGKIMQELES 

       310        320        330        340        350        360 
LFRGAGWNVI KVVWGRDWDP LLAKDTDGVL VHRMNTTPDG QFQTYSTSSG DYIREHFFGA 

       370        380        390        400        410        420 
DARLRRMVTD LADEDLSKLS RGGHDYRKLY AAYKAATEHA GQPTVILAHT IKGWTLGKDF 

       430        440        450        460        470        480 
EGRNATHQMK KLTKTELKEL RDRLYLEIPD SALDGNLPPY YRPGPDSEEI QYMRERRAGL 

       490        500        510        520        530        540 
GGSIPRRVVH ARTLPQPPKS IFDELRRGSG KQPVATTMAI VRLLKDLMKT KEMGARFVPV 

       550        560        570        580        590        600 
IPDEARTFGM DAMFPTAKIY SPHGQRYEAV DRELLLSYRE SESGQMLHEG ISEAGSMGSV 

       610        620        630        640        650        660 
IAAATAYSTH GQHMIPVYVF YSMFGFQRTG DQMWALGDQL GRAFLLGATA GRTTLNGEGL 

       670        680        690        700        710        720 
QHQDGHSLLL ASTNPACVSY DPAFAFEISH IVRDALDRMY GERNENVFYY LTVYNEPVPQ 

       730        740        750        760        770        780 
PAEPTGVDPT QIIAGMYRFR TADALTGGEE TPTGPVEDGA TESSTTTQAQ LLASGTGMRW 

       790        800        810        820        830        840 
ALAAQEMLAA DYGIAADVWS VTSWNELRRE ALVCERRNLL NPEQPPAVPY ISQILNGAPG 

       850        860        870        880        890        900 
PVIAVSDWMR AVPDQISRWV PQPYTSLGTD GFGRSDTRAA LRRHFNVDAE SVVVATLEAL 

       910        920        930        940 
TRTGDVEQAT VDDAIRRYGL RKDGANEAAL GNGATEENDQ PVSG

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW11298.1.
RefSeqYP_001506204.1. NC_009921.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8LFJ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5670262.
GenomeReviewsGene locus Franean1_1860 in contig CP000820_GR.
KEGGfre:Franean1_1860.
PATRIC21936620. VBIFraSp51419_1921.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8LFJ5_FRASN
AccessionPrimary (citable) accession number: A8LFJ5
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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