Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8LEP9 (ACDH2_FRASN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Ordered Locus Names:Franean1_4744
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP]
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_0000387662

Regions

Nucleotide binding9 – 124NAD By similarity
Nucleotide binding158 – 1669NAD By similarity

Sites

Active site1271Acyl-thioester intermediate By similarity
Binding site2861NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A8LEP9 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 1FCE2D0025AC3E29

FASTA30832,221
        10         20         30         40         50         60 
MQQVAIIGSG NIGTDLLIKI KRRSESLSVA AMVGIDPESD GLARARRLGV ATTSDGVAGL 

        70         80         90        100        110        120 
LAMPEFEQAG IVLDATSANA HRANAAALAP YGRRLIDLTP AALGPFVVPA VNLDEHLSAP 

       130        140        150        160        170        180 
NVNMTTCGGQ ATVPIVAAIS RVTPVAYAEI VATVASKSAG PGTRANIDEF TETTAHALES 

       190        200        210        220        230        240 
VGGARRGKAI IILNPAEPPL IMRDTVLCLV GDVDRDAVTE SIHRMIADVA AYVPGYRLKQ 

       250        260        270        280        290        300 
DVQFTPVDPA EMRILLPDDT VDVRWKVSVF LEVEGAAHYL PAYAGNLDIM TSAAVRVAER 


IAGAEVTA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000820 Genomic DNA. Translation: ABW14111.1.
RefSeqYP_001509017.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8LEP9.
SMRA8LEP9. Positions 3-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298653.Franean1_4744.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW14111; ABW14111; Franean1_4744.
GeneID5673086.
KEGGfre:Franean1_4744.
PATRIC21942650. VBIFraSp51419_4930.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAIATTHEG.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycFSP298653:GHPI-4759-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_FRASN
AccessionPrimary (citable) accession number: A8LEP9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 4, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families