SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8LEP9

- ACDH2_FRASN

UniProt

A8LEP9 - ACDH2_FRASN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Acetaldehyde dehydrogenase 2
Gene
Franean1_4744
Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei127 – 1271Acyl-thioester intermediate By similarity
Binding sitei286 – 2861NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 124NAD By similarity
Nucleotide bindingi158 – 1669NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciFSP298653:GHPI-4759-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Ordered Locus Names:Franean1_4744
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001313: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Acetaldehyde dehydrogenase 2UniRule annotation
PRO_0000387662Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_4744.

Structurei

3D structure databases

ProteinModelPortaliA8LEP9.
SMRiA8LEP9. Positions 3-308.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LEP9-1 [UniParc]FASTAAdd to Basket

« Hide

MQQVAIIGSG NIGTDLLIKI KRRSESLSVA AMVGIDPESD GLARARRLGV    50
ATTSDGVAGL LAMPEFEQAG IVLDATSANA HRANAAALAP YGRRLIDLTP 100
AALGPFVVPA VNLDEHLSAP NVNMTTCGGQ ATVPIVAAIS RVTPVAYAEI 150
VATVASKSAG PGTRANIDEF TETTAHALES VGGARRGKAI IILNPAEPPL 200
IMRDTVLCLV GDVDRDAVTE SIHRMIADVA AYVPGYRLKQ DVQFTPVDPA 250
EMRILLPDDT VDVRWKVSVF LEVEGAAHYL PAYAGNLDIM TSAAVRVAER 300
IAGAEVTA 308
Length:308
Mass (Da):32,221
Last modified:December 4, 2007 - v1
Checksum:i1FCE2D0025AC3E29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW14111.1.
RefSeqiWP_020462233.1. NC_009921.1.
YP_001509017.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW14111; ABW14111; Franean1_4744.
GeneIDi5673086.
KEGGifre:Franean1_4744.
PATRICi21942650. VBIFraSp51419_4930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW14111.1 .
RefSeqi WP_020462233.1. NC_009921.1.
YP_001509017.1. NC_009921.1.

3D structure databases

ProteinModelPortali A8LEP9.
SMRi A8LEP9. Positions 3-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298653.Franean1_4744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW14111 ; ABW14111 ; Franean1_4744 .
GeneIDi 5673086.
KEGGi fre:Franean1_4744.
PATRICi 21942650. VBIFraSp51419_4930.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci FSP298653:GHPI-4759-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EAN1pec.

Entry informationi

Entry nameiACDH2_FRASN
AccessioniPrimary (citable) accession number: A8LEP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi