A8LE47 (A8LE47_FRASN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase HAMAP MF_00006
Short name=ASAL HAMAP MF_00006
EC=4.3.2.1 HAMAP MF_00006

Alternative name(s):
Arginosuccinase HAMAP MF_00006

Gene names

Name:	argH HAMAP MF_00006
Ordered Locus Names:	Franean1_1744

Organism

Frankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW11182.1

Taxonomic identifier

298653 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. HAMAP MF_00006

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis HAMAP MF_00006
Cellular component	Cytoplasm HAMAP MF_00006
Molecular function	Lyase HAMAP MF_00006 EMBL ABW11182.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8LE47 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: BBE013326E7CD076	FASTA	511	54,426
	10 20 30 40 50 60 MDPERAQGDV ARTDAARTDT ADDTDGEDTG GHAGAGGQAD APASTPPLRL WGGRFAGGPA 70 80 90 100 110 120 EALARLSVSV QFDWRLAPYD LLASRSHARV LHRAGLLDDA ELTAMLGALD DLSDAVAHGR 130 140 150 160 170 180 FRPTIEDEDV HTALERGLLE RLGALGGKLR AGRSRNDQVA TDLRLYLRDH ARQVAARVTE 190 200 210 220 230 240 LSTALVGLAE QHVETPAPGM THLQHAQPIS FGHQLLAHVH AFARDTDRLR DWDRRASVSA 250 260 270 280 290 300 LGAGALAGSS LPLDPAGVAA ELGFDRAFAN SLDAVSDRDF AAEFLFIAAL IGVHLSRLGE 310 320 330 340 350 360 EIVLWTTREF GWVELDDAFA TGSSIMPQKK NPDVAELARG KSGRLIGALT GLLTTLKGLP 370 380 390 400 410 420 LAYDRDLQED KEPVFDAVDT LLVVLPAVTG MVATMRVRRE RLAAAAPDGF ALATDVAEYL 430 440 450 460 470 480 VRNGVAFREA HEAVGQLVAW CVAHDADMDE VSEDDLAVIS PLLTADVRSV LSVRGALEAR 490 500 510 SAPGGTAPAR VREQIEALGP VLDRDRAWAG S

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000820 Genomic DNA. Translation: ABW11182.1.
RefSeq	YP_001506088.1. NC_009921.1.
3D structure databases
ProteinModelPortal	A8LE47.
ModBase	Search...
Protein-protein interaction databases
STRING	A8LE47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5670146.
GenomeReviews	Gene locus Franean1_1744 in contig CP000820_GR.
KEGG	fre:Franean1_1744.
PATRIC	21936354. VBIFraSp51419_1790.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	MPGRTHL.
ProtClustDB	PRK00855.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8LE47_FRASN

Accession

Primary (citable) accession number: A8LE47

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)