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A8LE21

- DEF_FRASN

UniProt

A8LE21 - DEF_FRASN

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Protein

Peptide deformylase

Gene
def, Franean1_1718
Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901Iron By similarity
Metal bindingi132 – 1321Iron By similarity
Active sitei133 – 1331 By similarity
Metal bindingi136 – 1361Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciFSP298653:GHPI-1734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:Franean1_1718
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001313: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Peptide deformylaseUniRule annotationPRO_1000097312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_1718.

Structurei

3D structure databases

ProteinModelPortaliA8LE21.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OMAiMEMVFYP.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LE21-1 [UniParc]FASTAAdd to Basket

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MSVRDIRLLG DPVLRTVADP VATFDRELRR LVDDLADTMR DAGGVGLAAP    50
QLGVSLRIFT YLDDSDEVGH LINPVLGPFS EEMMDGEEGC LSLPGLAFDL 100
RRPERVLAVG QNSHGDPVTV EGSGILSRCL QHETDHLDGI LFIDRLDKET 150
KRAAMKAIRE AEWSNEPKPA VKVSPHPLFG RGR 183
Length:183
Mass (Da):20,091
Last modified:December 4, 2007 - v1
Checksum:i8F991F00211F4169
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW11156.1.
RefSeqiWP_020459328.1. NC_009921.1.
YP_001506062.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW11156; ABW11156; Franean1_1718.
GeneIDi5670120.
KEGGifre:Franean1_1718.
PATRICi21936300. VBIFraSp51419_1763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW11156.1 .
RefSeqi WP_020459328.1. NC_009921.1.
YP_001506062.1. NC_009921.1.

3D structure databases

ProteinModelPortali A8LE21.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298653.Franean1_1718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW11156 ; ABW11156 ; Franean1_1718 .
GeneIDi 5670120.
KEGGi fre:Franean1_1718.
PATRICi 21936300. VBIFraSp51419_1763.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OMAi MEMVFYP.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci FSP298653:GHPI-1734-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EAN1pec.

Entry informationi

Entry nameiDEF_FRASN
AccessioniPrimary (citable) accession number: A8LE21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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