A8LCN0 (A8LCN0_FRASN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137
Ordered Locus Names:	Franean1_0202

Organism

Frankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW09669.1

Taxonomic identifier

298653 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137
Ligand	ATP-binding HAMAP MF_00137 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 EMBL ABW09669.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8LCN0 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 8E5094D68BBAA95C	FASTA	354	38,447
	10 20 30 40 50 60 MLPAAAGIRI PTRTPGRSPR PGSAAGQPSG GITKRHVERA SRAGGYRYGR TMPLTHEEFA 70 80 90 100 110 120 GLTHLGSGKV RELFAIGDDA VLLVASDRIS AFDVVLPTEI PDKGAVLTGL SLWWFDQLGD 130 140 150 160 170 180 LVPSHVISSS VDEYPAELAP YAEQLRGRSM LCRRLDMVQI ECVARGYLTG SGLKDYRRSG 190 200 210 220 230 240 TVSGHPLPAG LEDGSRLPNP IYTPSTKAPI GEHDENISRD DAAGRVGAEL AAELERLTLQ 250 260 270 280 290 300 IFGRASDLAA ERGILLADTK FEFGHDADGV LRLADEVLTP DSSRFWPADA WTPGGTQPSY 310 320 330 340 350 DKQFIRDYLV STGWDRNPPA PELPDDIVES TRARYVEAYE RLTGISFKDY LSTA

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000820 Genomic DNA. Translation: ABW09669.1.
RefSeq	YP_001504575.1. NC_009921.1.
3D structure databases
ProteinModelPortal	A8LCN0.
ModBase	Search...
Protein-protein interaction databases
STRING	A8LCN0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5668627.
GenomeReviews	Gene locus Franean1_0202 in contig CP000820_GR.
KEGG	fre:Franean1_0202.
PATRIC	21933168. VBIFraSp51419_0213.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG555040.
OMA	LTLMDEV.
ProtClustDB	CLSK949061.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8LCN0_FRASN

Accession

Primary (citable) accession number: A8LCN0

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)