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A8LC78 (A8LC78_FRASN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:Franean1_6071
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW15415.1
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region115 – 12395-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site2415-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site8915-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9015-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1191Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
A8LC78 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: C38EC89C775AF628

FASTA17518,778
        10         20         30         40         50         60 
MADIEALAAR VRAASHLTGT FLLRSGRTST EYFDKYLFEA EPALLADIVE AMAAHLPPNT 

        70         80         90        100        110        120 
DLLAGLELGG VPLATLLSAR TGLPARFVRK KAKEYGTRRI AEGGEVEGRR IVLVEDVVTS 

       130        140        150        160        170 
GGAVLDATRV LREQGAVVED VLCVIDRQEG GRERLAEIGL TLLPTLTRAD LDAAR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW15415.1.
RefSeqYP_001510321.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8LC78.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8LC78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5674392.
GenomeReviewsGene locus Franean1_6071 in contig CP000820_GR.
KEGGfre:Franean1_6071.
PATRIC21945667. VBIFraSp51419_6431.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMAQTCLVIN.
ProtClustDBCLSK2486794.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8LC78_FRASN
AccessionPrimary (citable) accession number: A8LC78
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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