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Protein

Catalase-peroxidase

Gene

katG

Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei105Transition state stabilizerUniRule annotation1
Active sitei109Proton acceptorUniRule annotation1
Metal bindingi272Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2353. FspCP_EAN1pec.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Franean1_1533
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001313 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547981 – 743Catalase-peroxidaseAdd BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki108 ↔ 231Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-257)UniRule annotation
Cross-linki231 ↔ 257Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-108)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi298653.Franean1_1533.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8LBC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENHETVVS ELNEESGGGC PVAHERAPHP TQGGGNRGWW PNRLNLKILA
60 70 80 90 100
KNPAVANPLG EEFDYAAAFR TLDLPAVKRD IAQVLTTSQD WWPADYGHYG
110 120 130 140 150
PFMIRMAWHS AGTYRISDGR GGGGAGQQRF APLNSWPDNG NLDKARRLLW
160 170 180 190 200
PVKKKYGQAL SWADLMILAG NVALESMGFT TFGFAGGRED VWEPDEDVYW
210 220 230 240 250
GPETTWLGDE RYTGDRELEN PLGAVQMGLI YVNPEGPNGT PDPLAAARDI
260 270 280 290 300
RETFRRMAMD DEETVALIAG GHTFGKTHGA GDPDNVGPEP EGAPLETQGL
310 320 330 340 350
GWKNAFGTGK GADAITSGLE GAWTPTPVSW DNSFFETLFG YEWALTKSPA
360 370 380 390 400
GAYQWKPKGG AGAGTVPDAH DAAKSHAPTM LTTDLALRFD PVYEPISRRF
410 420 430 440 450
LEHPDELADA FARAWFKLTH RDMGPVARYL GPEVPAETLL WQDPVPAVDH
460 470 480 490 500
ELVDAADVAA LKVRVLASGL SVSELVATAW ASASTFRGGD KRGGANGARI
510 520 530 540 550
RLEPQRGWEV NEPDRLAAVL GTLTGIQEEF HAARTDGRRV SLADLIVLAG
560 570 580 590 600
GAAVEQAARE AGFDVEVPFT PGRTDASQEL TDVESFAALE PAADGFRNYL
610 620 630 640 650
GKGQRLPAEY LLLDRANLLT LSAPELTVLV GGLRVLGANF RQSSLGVLTA
660 670 680 690 700
TPGVLTNDFF ANLLDLGTTW RPSGEDDNVF EGRDAATGEL TWTGSRVDLV
710 720 730 740
FGSNSELRAF AEVYASDDAR EKFVRDFVAA WAKVMNLDRY DLA
Length:743
Mass (Da):80,421
Last modified:December 4, 2007 - v1
Checksum:i46AE1825592C563C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000820 Genomic DNA. Translation: ABW10973.1.
RefSeqiWP_020459147.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW10973; ABW10973; Franean1_1533.
KEGGifre:Franean1_1533.
PATRICi21935910. VBIFraSp51419_1567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000820 Genomic DNA. Translation: ABW10973.1.
RefSeqiWP_020459147.1. NC_009921.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi298653.Franean1_1533.

Protein family/group databases

PeroxiBasei2353. FspCP_EAN1pec.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW10973; ABW10973; Franean1_1533.
KEGGifre:Franean1_1533.
PATRICi21935910. VBIFraSp51419_1567.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_FRASN
AccessioniPrimary (citable) accession number: A8LBC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.