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A8LB22 (A8LB22_FRASN) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897
Ordered Locus Names:Franean1_0007
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW09476.1
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length837 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
A8LB22 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 21B4B9FCB63971AE

FASTA83792,281
        10         20         30         40         50         60 
MVDVLPPPPG DRIEPIGIEV EMQRSYLDYA MSVIVGRALP EVRDGLKPVH RRVLYAMYDG 

        70         80         90        100        110        120 
GYRPDRGYFK CSRVVGDVMG NYHPHGDSAI YDTLVRLAQP WSLRYPLVDG NGNFGSPGND 

       130        140        150        160        170        180 
PPAAMRYTEA RMAPLAMEML RDIDQETVDF APNYDGRSQE PLVLPSRFPN LLVNGAGGIA 

       190        200        210        220        230        240 
VGMATNIPPH NLVEVAKGVQ WSLDHPEATA EELLEALLGI IKGPDFPTHG LIVGRNGIED 

       250        260        270        280        290        300 
AYRTGRGSIR MRAVVNVEEN KGRTQLVVTE LPYQVNPDNL AEKIAELVRD NKVTGISDVR 

       310        320        330        340        350        360 
DETSARIGQR LVIDLKRDAV AKVVLNNLYK HTQLQDTFGV NMLAIVDGVP RTLRLDQMIS 

       370        380        390        400        410        420 
YYVEHQVDVI VRRTRYQLRK ARERLHVLDG LLIALDHLDE VIALIRNAES AEVARGQLMA 

       430        440        450        460        470        480 
RFSLSEIQAT AILDMQLRRL AFLERQRIID EAAELRAKID ELEAILASPV RQREIIGQEL 

       490        500        510        520        530        540 
AEVVEKFGDE RRTRLVPFEG DMSVEDLIAR EDVVVTVTRG GYAKRTKTDL YRSQKRGGKG 

       550        560        570        580        590        600 
VQGAALREDD IVEHFFVTTT HHWLLFFTNK GRVYRAKAHE LPEQARSAKG QHVANILAFS 

       610        620        630        640        650        660 
QDERIAEVMA IQDYQAAPYL VLATKRGLCK KTALTDFDSN RAGGLVAINL RDDDELISAR 

       670        680        690        700        710        720 
LVAPGDDLLL VSRNAQSIRF HADDEQLRPM GRATSGVIGM RFDEADELLS MDVVVPESPA 

       730        740        750        760        770        780 
DLLVATSGGY AKRTPLAEYP IQGRGGKGVL TAKIVSTRGG LVGALVVEPN DQLYAITSNG 

       790        800        810        820        830 
GVLRTVAKDV RRAQRQTMGV RLIDLEAGVQ VVGVARNADA NDSDGDGETA GSDGTAG

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW09476.1.
RefSeqYP_001504382.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8LB22.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8LB22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5668434.
GenomeReviewsGene locus Franean1_0007 in contig CP000820_GR.
KEGGfre:Franean1_0007.
PATRIC21932754. VBIFraSp51419_0007.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG635183.
OMATGRGRIY.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8LB22_FRASN
AccessionPrimary (citable) accession number: A8LB22
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info