A8LAZ9 (GLMM_FRASN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	Franean1_6016

Organism

Frankia sp. (strain EAN1pec) [Complete proteome] [HAMAP]

Taxonomic identifier

298653 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_1000201102
Sites
	Active site	120	1	Phosphoserine intermediate By similarity
	Metal binding	120	1	Magnesium; via phosphate group By similarity
	Metal binding	261	1	Magnesium By similarity
	Metal binding	263	1	Magnesium By similarity
	Metal binding	265	1	Magnesium By similarity
Amino acid modifications
	Modified residue	120	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8LAZ9 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 9BDC38BBC2A2198C	FASTA	467	47,985
	10 20 30 40 50 60 MARLFGTDGV RGVANADLTA ELALALASAA VEEVADRGTP PPGPVDGVPV ARSAHGIDHR 70 80 90 100 110 120 PLVVVGRDTR PSGEFLEAAV VAGLARAGAD VTRIGVVPTP AVSYVVAATG ADLGVMLSAS 130 140 150 160 170 180 HNPMPDNGIK LFAAGGLKLP DDVEDAIERR MAGPAARRPV AAAVGRVRDD SMLVDGYVDH 190 200 210 220 230 240 LLATLPGGPG GLRGLRVVVD CAQGAASDLA PRVLRAAGAD VIALHADGDG LRINDRSGAT 250 260 270 280 290 300 HLDSLRDAVV AHGADAGIAH DGDADRCLAV DSAGEIVDGD QILALCALAL AERGELERGT 310 320 330 340 350 360 VVVTVMSNLG FHHAMRDAGI DVVTTPVGDR YVLEAMRSGA YSLGGEQSGH VVFLRHAGTG 370 380 390 400 410 420 DGLLTALQIL GRMAETSQPL HELAKAMTRL PQVLVNVRGV DRARAETSDE LRAAVADAEA 430 440 450 460 ELAGAGRVLL RPSGTEPLVR VMVEAPTDEL ARDVAGRLAD VVQRALR

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EAN1pec.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000820 Genomic DNA. Translation: ABW15360.1.
RefSeq	YP_001510266.1. NC_009921.1.
3D structure databases
ProteinModelPortal	A8LAZ9.
ModBase	Search...
Protein-protein interaction databases
STRING	A8LAZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5674337.
GenomeReviews	Gene locus Franean1_6016 in contig CP000820_GR.
KEGG	fre:Franean1_6016.
PATRIC	21945541. VBIFraSp51419_6371.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644964.
OMA	GVGSTHL.
ProtClustDB	PRK14318.
Enzyme and pathway databases
BioCyc	FSP1855:FRANEAN1_6016-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_FRASN

Accession

Primary (citable) accession number: A8LAZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program