A8LAA2 (ACDH1_FRASN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 1
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1

Gene names

Ordered Locus Names:

Franean1_2883

Organism

Frankia sp. (strain EAN1pec) [Complete proteome] [HAMAP]

Taxonomic identifier

298653 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Acetaldehyde dehydrogenase 1 HAMAP MF_01657		PRO_0000387661
Regions
	Nucleotide binding	18 – 21	4	NAD By similarity
	Nucleotide binding	167 – 175	9	NAD By similarity
Sites
	Binding site	297	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8LAA2 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 4FA384F86813A369	FASTA	324	33,893
	10 20 30 40 50 60 MATATSGTGK TKVAVIGSGN IGTDLMIKIL RTSEVLEIAA MVGIDAESDG LARARRLKVA 70 80 90 100 110 120 TTHEGIDGLL RMPEFDDIEI VFDATSAGAH ARNDELLRAR GRRVIDLTPA AIGPYVVPPV 130 140 150 160 170 180 NLDAHLDAPN INMVTCGGQA TIPIVAAVNA VTPVAYAEIV ASIASKSAGP GTRANIDEFT 190 200 210 220 230 240 ETTASAIEKV GGAARGKAII VLNPAEPPLV MRDTVYCLIG ASDQATQDAV VASVTRMVDR 250 260 270 280 290 300 VREYVPGYRL KQQVQIEEAS ADDPLRQLAP DGSEPAKVTV FLEVTGAAHY LPAYAGNLDI 310 320 MTSAALRAGE RLAQTLTQRE GATA

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EAN1pec.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000820 Genomic DNA. Translation: ABW12304.1.
RefSeq	YP_001507210.1. NC_009921.1.
3D structure databases
ProteinModelPortal	A8LAA2.
SMR	A8LAA2. Positions 10-316.
ModBase	Search...
Protein-protein interaction databases
STRING	A8LAA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5671270.
GenomeReviews	Gene locus Franean1_2883 in contig CP000820_GR.
KEGG	fre:Franean1_2883.
PATRIC	21938737. VBIFraSp51419_2977.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG300125.
OMA	GLEVIGG.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	FSP1855:FRANEAN1_2883-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH1_FRASN

Accession

Primary (citable) accession number: A8LAA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program