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A8LAA2 (ACDH1_FRASN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Ordered Locus Names:Franean1_2883
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP]
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657
PRO_0000387661

Regions

Nucleotide binding18 – 214NAD By similarity
Nucleotide binding167 – 1759NAD By similarity

Sites

Active site1361Acyl-thioester intermediate By similarity
Binding site2971NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A8LAA2 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 4FA384F86813A369

FASTA32433,893
        10         20         30         40         50         60 
MATATSGTGK TKVAVIGSGN IGTDLMIKIL RTSEVLEIAA MVGIDAESDG LARARRLKVA 

        70         80         90        100        110        120 
TTHEGIDGLL RMPEFDDIEI VFDATSAGAH ARNDELLRAR GRRVIDLTPA AIGPYVVPPV 

       130        140        150        160        170        180 
NLDAHLDAPN INMVTCGGQA TIPIVAAVNA VTPVAYAEIV ASIASKSAGP GTRANIDEFT 

       190        200        210        220        230        240 
ETTASAIEKV GGAARGKAII VLNPAEPPLV MRDTVYCLIG ASDQATQDAV VASVTRMVDR 

       250        260        270        280        290        300 
VREYVPGYRL KQQVQIEEAS ADDPLRQLAP DGSEPAKVTV FLEVTGAAHY LPAYAGNLDI 

       310        320 
MTSAALRAGE RLAQTLTQRE GATA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000820 Genomic DNA. Translation: ABW12304.1.
RefSeqYP_001507210.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8LAA2.
SMRA8LAA2. Positions 10-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING298653.Franean1_2883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW12304; ABW12304; Franean1_2883.
GeneID5671270.
KEGGfre:Franean1_2883.
PATRIC21938737. VBIFraSp51419_2977.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHQGNVNM.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycFSP298653:GHPI-2903-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_FRASN
AccessionPrimary (citable) accession number: A8LAA2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families