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A8LAA2

- ACDH1_FRASN

UniProt

A8LAA2 - ACDH1_FRASN

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Protein

Acetaldehyde dehydrogenase 1

Gene

Franean1_2883

Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei136 – 1361Acyl-thioester intermediateUniRule annotation
Binding sitei297 – 2971NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 214NADUniRule annotation
Nucleotide bindingi167 – 1759NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciFSP298653:GHPI-2903-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:Franean1_2883
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001313: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Acetaldehyde dehydrogenase 1PRO_0000387661Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_2883.

Structurei

3D structure databases

ProteinModelPortaliA8LAA2.
SMRiA8LAA2. Positions 10-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHQGNVNM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A8LAA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATATSGTGK TKVAVIGSGN IGTDLMIKIL RTSEVLEIAA MVGIDAESDG
60 70 80 90 100
LARARRLKVA TTHEGIDGLL RMPEFDDIEI VFDATSAGAH ARNDELLRAR
110 120 130 140 150
GRRVIDLTPA AIGPYVVPPV NLDAHLDAPN INMVTCGGQA TIPIVAAVNA
160 170 180 190 200
VTPVAYAEIV ASIASKSAGP GTRANIDEFT ETTASAIEKV GGAARGKAII
210 220 230 240 250
VLNPAEPPLV MRDTVYCLIG ASDQATQDAV VASVTRMVDR VREYVPGYRL
260 270 280 290 300
KQQVQIEEAS ADDPLRQLAP DGSEPAKVTV FLEVTGAAHY LPAYAGNLDI
310 320
MTSAALRAGE RLAQTLTQRE GATA
Length:324
Mass (Da):33,893
Last modified:December 4, 2007 - v1
Checksum:i4FA384F86813A369
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW12304.1.
RefSeqiWP_020460456.1. NC_009921.1.
YP_001507210.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW12304; ABW12304; Franean1_2883.
GeneIDi5671270.
KEGGifre:Franean1_2883.
PATRICi21938737. VBIFraSp51419_2977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW12304.1 .
RefSeqi WP_020460456.1. NC_009921.1.
YP_001507210.1. NC_009921.1.

3D structure databases

ProteinModelPortali A8LAA2.
SMRi A8LAA2. Positions 10-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298653.Franean1_2883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW12304 ; ABW12304 ; Franean1_2883 .
GeneIDi 5671270.
KEGGi fre:Franean1_2883.
PATRICi 21938737. VBIFraSp51419_2977.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HQGNVNM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci FSP298653:GHPI-2903-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EAN1pec.

Entry informationi

Entry nameiACDH1_FRASN
AccessioniPrimary (citable) accession number: A8LAA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 4, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3