A8L9Y9 (A8L9Y9_FRASN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add HAMAP MF_00540
Ordered Locus Names:	Franean1_5933

Organism

Frankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW15277.1

Taxonomic identifier

298653 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540
Ligand	Metal-binding HAMAP MF_00540 Zinc HAMAP MF_00540
Molecular function	Hydrolase HAMAP MF_00540 EMBL ABW15277.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	213	1	Proton donor By similarity HAMAP MF_00540
	Metal binding	26	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	28	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	210	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	302	1	Zinc; catalytic By similarity HAMAP MF_00540
	Binding site	28	1	Substrate By similarity HAMAP MF_00540
	Binding site	30	1	Substrate By similarity HAMAP MF_00540
	Binding site	183	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
	Site	234	1	Important for catalytic activity By similarity HAMAP MF_00540

Sequences

	Sequence		Length	Mass (Da)
	A8L9Y9 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: F5F185D5B3C32643	FASTA	364	39,599
	10 20 30 40 50 60 MDIPAGQASE KITEAAIRRV PKVLLHDHLD GGLRPATIVE LADATGYTRL PTTDVDKLGT 70 80 90 100 110 120 WFRGGAHTGS LVRYLETFSH TVGVMQTPEA VARVARECAE DLAADGVVYA EVRFAPELHV 130 140 150 160 170 180 EQGMSLDEVV EAALDGFRAG SAGTGLHVRA LVTAMRHQAR SLEIAELAVR WREAGVVGFD 190 200 210 220 230 240 IAGAEAGNPP TRHLDAFQYI QRANGHFTIH AGEAFGLPSI WEALQWCNAD RLGHGVRIVD 250 260 270 280 290 300 DITVDPDGNA TLGDLADYVR DVRVPLEMCP SSNVHTGAAP SIERHPIGLL RRLHFRVTVN 310 320 330 340 350 360 TDNRLMSGVT LSSEFATLVE TFGYGWSDIR WLTVNAMKSA FLPFDQRLAL INEVIKPGFE GLVP

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000820 Genomic DNA. Translation: ABW15277.1.
RefSeq	YP_001510183.1. NC_009921.1.
3D structure databases
ProteinModelPortal	A8L9Y9.
ModBase	Search...
Protein-protein interaction databases
STRING	A8L9Y9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5674254.
GenomeReviews	Gene locus Franean1_5933 in contig CP000820_GR.
KEGG	fre:Franean1_5933.
PATRIC	21945343. VBIFraSp51419_6272.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	PYYMAMN.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8L9Y9_FRASN

Accession

Primary (citable) accession number: A8L9Y9

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)