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A8L8S7 (ILVD_FRASN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:Franean1_7305
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP]
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_1000089384

Sites

Metal binding1221Iron-sulfur (4Fe-4S) Potential
Metal binding1971Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
A8L8S7 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 58C7BA066C16A95E

FASTA61764,400
        10         20         30         40         50         60 
MPALRSRTTT HGRNMAGARA LWRATGMTDD DFGKPIVAIA NSFTQFVPGH VHLRDLGKIV 

        70         80         90        100        110        120 
ADAVAGSGGV AKEFNTIAVD DGIAMGHGGM LYSLPSREII ADSVEYMVNA HCADALVCIS 

       130        140        150        160        170        180 
NCDKITPGML IAALRLNIPT VFVSGGAMES GHAVVTGGIV RSRLDLIDAM TAAVNPDVSD 

       190        200        210        220        230        240 
ADLDTIERSA CPTCGSCSGM FTANSMNCLT EALGLALPGN GSTLATAAAR RGLFVEAGRL 

       250        260        270        280        290        300 
VVDLARRYYE KDDEAVLPRS IASAAAFRNA FAVDVAMGGS TNTVLHLLAA AVEAGVEVTL 

       310        320        330        340        350        360 
DDIDQVSRSV ACLCKVAPSS TDYYMEDVHR AGGIPAILGE LDRGGLVDPN VHSVHAASLR 

       370        380        390        400        410        420 
EFLDRWDVRG ADPSPDAIEL FHAAPGGVRT VEPFGSTNRW DTLDTDAKNG CIRSVEHAYS 

       430        440        450        460        470        480 
ADGGLAVLRG NLAPDGAVVK TAGVDESQWT FRGPALVVES QEAAVDAILN KVVKAGDVII 

       490        500        510        520        530        540 
VRYEGPRGGP GMQEMLYPTA FLKGRGLGPK CALITDGRFS GGSSGLSIGH VSPEAAHGGP 

       550        560        570        580        590        600 
IALVRDGDLV EIDIPRRRID LLVPDAELAA RRAEIEANGG YHPANRERVV SAALRAYAAM 

       610 
ATSASTGAAR DVRLITG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW16624.1.
RefSeqYP_001511530.1. NC_009921.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8L8S7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5675606.
GenomeReviewsGene locus Franean1_7305 in contig CP000820_GR.
KEGGfre:Franean1_7305.
PATRIC21948440. VBIFraSp51419_7811.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG671001.
OMASQDCRWP.
ProtClustDBPRK12448.

Enzyme and pathway databases

BioCycFSP1855:FRANEAN1_7305-MONOMER.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_FRASN
AccessionPrimary (citable) accession number: A8L8S7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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