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A8L7R3 (A8L7R3_FRASN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 1 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 1 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 1 HAMAP MF_01815
Gene names
Name:fabH1 HAMAP MF_01815
Ordered Locus Names:Franean1_1264
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW10718.1
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region239 – 2435ACP-binding By similarity HAMAP MF_01815

Sites

Active site1131 By similarity HAMAP MF_01815
Active site2381 By similarity HAMAP MF_01815
Active site2681 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A8L7R3 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: E12F2D56CC9B9B5F

FASTA31232,126
        10         20         30         40         50         60 
MTGARLLGLG TYRPGRLVTN DEITRQVDTS DLWIRTRTGI STRRIADDDE TTVAMGVSAA 

        70         80         90        100        110        120 
DKALAAAGLA ARDVDAVIGA TCTAPSQIPG TAPQVASRLG ASAAGTFDIN GGCAGFCYAV 

       130        140        150        160        170        180 
STAADMVRAG SARHVLVVAT ERLSDYTDWS DRSTCILLAD GAGAVVISAA ETDHIGPAVW 

       190        200        210        220        230        240 
GHDGSRPEAI QVPGRGDNSF RMEGPAVFRW AISLVPTLRT VCDRAGVAPE ELAAIVPHQA 

       250        260        270        280        290        300 
NLRIVEALAG GLGVPDVPIA RDVVDSGNTS AASIPLALDR MMEAGEVVSG DPVLLFGFGA 

       310 
GLTYCGQVVR CP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW10718.1.
RefSeqYP_001505624.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8L7R3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8L7R3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5669677.
GenomeReviewsGene locus Franean1_1264 in contig CP000820_GR.
KEGGfre:Franean1_1264.
PATRIC21935396. VBIFraSp51419_1312.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMASNCFIFA.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8L7R3_FRASN
AccessionPrimary (citable) accession number: A8L7R3
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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