A8L6G3 (A8L6G3_FRASN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase 1 HAMAP MF_00102
Short name=DHPR 1 HAMAP MF_00102
EC=1.3.1.26 HAMAP MF_00102

Gene names

Name:	dapB1 HAMAP MF_00102
Ordered Locus Names:	Franean1_1191

Organism

Frankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW10645.1

Taxonomic identifier

298653 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family. HAMAP MF_00102

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis HAMAP MF_00102 Lysine biosynthesis HAMAP MF_00102
Cellular component	Cytoplasm HAMAP MF_00102
Ligand	NADP HAMAP MF_00102
Molecular function	Oxidoreductase HAMAP MF_00102 EMBL ABW10645.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8L6G3 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 3B0B2CFEAB3F2BC2	FASTA	247	25,301
	10 20 30 40 50 60 MIGVGVLGAR GRMGTTVCDA VRAAPDLELV AEVDAGDDRS PAAKADVVVD FTHPDAVMDN 70 80 90 100 110 120 LRWAVENRVH AVVGTTGFDD ARFAALRGWL AAEPSVGVLV APNFGIAAVL MMMFAARAAP 130 140 150 160 170 180 YFESVEIVEL HHPGKADAPS GTARRTAELI AAARASAGLP AAGPDATTSA LDGARGARVS 190 200 210 220 230 240 GVPVHAVRLG GLVAHQEVLL GGAGETLTIR HDSLDRASFM PGVLLAVREV AARPGLTVGL EPLLDLG

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000820 Genomic DNA. Translation: ABW10645.1.
RefSeq	YP_001505551.1. NC_009921.1.
3D structure databases
ProteinModelPortal	A8L6G3.
SMR	A8L6G3. Positions 4-246.
ModBase	Search...
Protein-protein interaction databases
STRING	A8L6G3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5669604.
GenomeReviews	Gene locus Franean1_1191 in contig CP000820_GR.
KEGG	fre:Franean1_1191.
PATRIC	21935240. VBIFraSp51419_1234.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG594002.
OMA	DRASFMP.
ProtClustDB	PRK00048.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8L6G3_FRASN

Accession

Primary (citable) accession number: A8L6G3

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)