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A8L6G1

- PNP_FRASN

UniProt

A8L6G1 - PNP_FRASN

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi509 – 5091MagnesiumUniRule annotation
Metal bindingi515 – 5151MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciFSP298653:GHPI-1207-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Franean1_1189
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001313: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Polyribonucleotide nucleotidyltransferasePRO_1000147922Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_1189.

Structurei

3D structure databases

ProteinModelPortaliA8L6G1.
SMRiA8L6G1. Positions 3-712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini575 – 63460KHUniRule annotationAdd
BLAST
Domaini646 – 71873S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8L6G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDSTQAAEA VITTPTGART VRFETGRLAR QAAGAVVAHL GDTMVLSATT
60 70 80 90 100
VSRSPKEQLD FFPLTVDVEE RMYAAGRIPG SFFRREGRPS EDAILTCRLI
110 120 130 140 150
DRPLRPSFAK GLRNEIQVVA TVLALDPDTL YDVVAINAAS ASTMLAGLPF
160 170 180 190 200
SGPIGATRVG YVDGDWIAFP THSELERATF DMVVAGRVLE DGSDVAIMMV
210 220 230 240 250
EAEATPGTVA LVAGGAPAPT EEVVAAGLEA AKPAIRELCR AQSELAAGAA
260 270 280 290 300
KPQREFPLFI DYHDDVLETL TAAVGEELAA ALRIAGKAER ETELERVRAL
310 320 330 340 350
AVEKVSGQFE GRDKEISPAY RALTKKLVRS RIVTDGVRID GRSTTEIREL
360 370 380 390 400
SAEVDYIPRV HGSALFERGE TQILGVTTLA MLRMEQTVDT LNPDRTKRYM
410 420 430 440 450
HNYNFPPYST GETGRVGSPK RREIGHGALA ERALLPVLPS REEFPYAIRQ
460 470 480 490 500
VSEALSSNGS TSMGSVCAST LSLLNAGVPL KAPVAGIAMG LIREGDAFVT
510 520 530 540 550
LTDILGAEDA YGDMDFKVAG TQEFVTALQL DTKLDGIPAS VLAGALQQAR
560 570 580 590 600
AARLTILEVM AEAIGGPDEM SAHAPRVISV KIPVDKIGEV IGPKGKMINQ
610 620 630 640 650
IQADSGAEIT VEDDGTIYIG AADGPAAETA RSAINAIANP QMPEVGERYL
660 670 680 690 700
GTIVKITNFG AFVSLTPGKD GLLHVSKLKQ LAGGKRVEKV EDVLSVGQKL
710 720
QVEITEIDAR GKISLAPGAE SIDTVSAGS
Length:729
Mass (Da):77,321
Last modified:December 4, 2007 - v1
Checksum:iBDD9304F3EB66915
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW10643.1.
RefSeqiWP_020458819.1. NC_009921.1.
YP_001505549.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW10643; ABW10643; Franean1_1189.
GeneIDi5669602.
KEGGifre:Franean1_1189.
PATRICi21935236. VBIFraSp51419_1232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW10643.1 .
RefSeqi WP_020458819.1. NC_009921.1.
YP_001505549.1. NC_009921.1.

3D structure databases

ProteinModelPortali A8L6G1.
SMRi A8L6G1. Positions 3-712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298653.Franean1_1189.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW10643 ; ABW10643 ; Franean1_1189 .
GeneIDi 5669602.
KEGGi fre:Franean1_1189.
PATRICi 21935236. VBIFraSp51419_1232.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci FSP298653:GHPI-1207-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EAN1pec.

Entry informationi

Entry nameiPNP_FRASN
AccessioniPrimary (citable) accession number: A8L6G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3