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A8L6G1

- PNP_FRASN

UniProt

A8L6G1 - PNP_FRASN

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Franean1_1189
Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi509 – 5091Magnesium By similarity
Metal bindingi515 – 5151Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciFSP298653:GHPI-1207-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Franean1_1189
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001313: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000147922Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_1189.

Structurei

3D structure databases

ProteinModelPortaliA8L6G1.
SMRiA8L6G1. Positions 3-712.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini575 – 63460KH
Add
BLAST
Domaini646 – 71873S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8L6G1-1 [UniParc]FASTAAdd to Basket

« Hide

MDDSTQAAEA VITTPTGART VRFETGRLAR QAAGAVVAHL GDTMVLSATT    50
VSRSPKEQLD FFPLTVDVEE RMYAAGRIPG SFFRREGRPS EDAILTCRLI 100
DRPLRPSFAK GLRNEIQVVA TVLALDPDTL YDVVAINAAS ASTMLAGLPF 150
SGPIGATRVG YVDGDWIAFP THSELERATF DMVVAGRVLE DGSDVAIMMV 200
EAEATPGTVA LVAGGAPAPT EEVVAAGLEA AKPAIRELCR AQSELAAGAA 250
KPQREFPLFI DYHDDVLETL TAAVGEELAA ALRIAGKAER ETELERVRAL 300
AVEKVSGQFE GRDKEISPAY RALTKKLVRS RIVTDGVRID GRSTTEIREL 350
SAEVDYIPRV HGSALFERGE TQILGVTTLA MLRMEQTVDT LNPDRTKRYM 400
HNYNFPPYST GETGRVGSPK RREIGHGALA ERALLPVLPS REEFPYAIRQ 450
VSEALSSNGS TSMGSVCAST LSLLNAGVPL KAPVAGIAMG LIREGDAFVT 500
LTDILGAEDA YGDMDFKVAG TQEFVTALQL DTKLDGIPAS VLAGALQQAR 550
AARLTILEVM AEAIGGPDEM SAHAPRVISV KIPVDKIGEV IGPKGKMINQ 600
IQADSGAEIT VEDDGTIYIG AADGPAAETA RSAINAIANP QMPEVGERYL 650
GTIVKITNFG AFVSLTPGKD GLLHVSKLKQ LAGGKRVEKV EDVLSVGQKL 700
QVEITEIDAR GKISLAPGAE SIDTVSAGS 729
Length:729
Mass (Da):77,321
Last modified:December 4, 2007 - v1
Checksum:iBDD9304F3EB66915
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW10643.1.
RefSeqiWP_020458819.1. NC_009921.1.
YP_001505549.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW10643; ABW10643; Franean1_1189.
GeneIDi5669602.
KEGGifre:Franean1_1189.
PATRICi21935236. VBIFraSp51419_1232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000820 Genomic DNA. Translation: ABW10643.1 .
RefSeqi WP_020458819.1. NC_009921.1.
YP_001505549.1. NC_009921.1.

3D structure databases

ProteinModelPortali A8L6G1.
SMRi A8L6G1. Positions 3-712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298653.Franean1_1189.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW10643 ; ABW10643 ; Franean1_1189 .
GeneIDi 5669602.
KEGGi fre:Franean1_1189.
PATRICi 21935236. VBIFraSp51419_1232.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci FSP298653:GHPI-1207-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EAN1pec.

Entry informationi

Entry nameiPNP_FRASN
AccessioniPrimary (citable) accession number: A8L6G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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