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A8L6G1

- PNP_FRASN

UniProt

A8L6G1 - PNP_FRASN

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi509 – 5091MagnesiumUniRule annotation
    Metal bindingi515 – 5151MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciFSP298653:GHPI-1207-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Franean1_1189
    OrganismiFrankia sp. (strain EAN1pec)
    Taxonomic identifieri298653 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
    ProteomesiUP000001313: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Polyribonucleotide nucleotidyltransferasePRO_1000147922Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi298653.Franean1_1189.

    Structurei

    3D structure databases

    ProteinModelPortaliA8L6G1.
    SMRiA8L6G1. Positions 3-712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini575 – 63460KHUniRule annotationAdd
    BLAST
    Domaini646 – 71873S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8L6G1-1 [UniParc]FASTAAdd to Basket

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    MDDSTQAAEA VITTPTGART VRFETGRLAR QAAGAVVAHL GDTMVLSATT    50
    VSRSPKEQLD FFPLTVDVEE RMYAAGRIPG SFFRREGRPS EDAILTCRLI 100
    DRPLRPSFAK GLRNEIQVVA TVLALDPDTL YDVVAINAAS ASTMLAGLPF 150
    SGPIGATRVG YVDGDWIAFP THSELERATF DMVVAGRVLE DGSDVAIMMV 200
    EAEATPGTVA LVAGGAPAPT EEVVAAGLEA AKPAIRELCR AQSELAAGAA 250
    KPQREFPLFI DYHDDVLETL TAAVGEELAA ALRIAGKAER ETELERVRAL 300
    AVEKVSGQFE GRDKEISPAY RALTKKLVRS RIVTDGVRID GRSTTEIREL 350
    SAEVDYIPRV HGSALFERGE TQILGVTTLA MLRMEQTVDT LNPDRTKRYM 400
    HNYNFPPYST GETGRVGSPK RREIGHGALA ERALLPVLPS REEFPYAIRQ 450
    VSEALSSNGS TSMGSVCAST LSLLNAGVPL KAPVAGIAMG LIREGDAFVT 500
    LTDILGAEDA YGDMDFKVAG TQEFVTALQL DTKLDGIPAS VLAGALQQAR 550
    AARLTILEVM AEAIGGPDEM SAHAPRVISV KIPVDKIGEV IGPKGKMINQ 600
    IQADSGAEIT VEDDGTIYIG AADGPAAETA RSAINAIANP QMPEVGERYL 650
    GTIVKITNFG AFVSLTPGKD GLLHVSKLKQ LAGGKRVEKV EDVLSVGQKL 700
    QVEITEIDAR GKISLAPGAE SIDTVSAGS 729
    Length:729
    Mass (Da):77,321
    Last modified:December 4, 2007 - v1
    Checksum:iBDD9304F3EB66915
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000820 Genomic DNA. Translation: ABW10643.1.
    RefSeqiWP_020458819.1. NC_009921.1.
    YP_001505549.1. NC_009921.1.

    Genome annotation databases

    EnsemblBacteriaiABW10643; ABW10643; Franean1_1189.
    GeneIDi5669602.
    KEGGifre:Franean1_1189.
    PATRICi21935236. VBIFraSp51419_1232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000820 Genomic DNA. Translation: ABW10643.1 .
    RefSeqi WP_020458819.1. NC_009921.1.
    YP_001505549.1. NC_009921.1.

    3D structure databases

    ProteinModelPortali A8L6G1.
    SMRi A8L6G1. Positions 3-712.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 298653.Franean1_1189.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW10643 ; ABW10643 ; Franean1_1189 .
    GeneIDi 5669602.
    KEGGi fre:Franean1_1189.
    PATRICi 21935236. VBIFraSp51419_1232.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci FSP298653:GHPI-1207-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EAN1pec.

    Entry informationi

    Entry nameiPNP_FRASN
    AccessioniPrimary (citable) accession number: A8L6G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3