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Protein

Dihydrolipoyl dehydrogenase

Gene

Franean1_5475

Organism
Frankia sp. (strain EAN1pec)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciFSP298653:GHPI-5402-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Franean1_5475Imported
OrganismiFrankia sp. (strain EAN1pec)Imported
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001313 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_5475.

Structurei

3D structure databases

ProteinModelPortaliA8L4L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 326FAD/NAD-binding_domInterPro annotationAdd BLAST322
Domaini347 – 455Pyr_redox_dimInterPro annotationAdd BLAST109

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiCSDGMTK.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8L4L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHFDLVVL GGGPGGYVAA IRAAQLGLSV AVVEEKYWGG VCLNVGCIPS
60 70 80 90 100
KALLRNAELA HLFAHEAKTF GISGEVSFDF GAAFDRSRQV AEGRVKGVHF
110 120 130 140 150
LMKKNKITEF TGRGTFRDPN TLDVALSAGG TDQVSFDHAI IATGSRVRLL
160 170 180 190 200
PGVELSDNIV TYETQILTRE LPRSMAIVGA GAIGMEFAYV LRNYGVDVTI
210 220 230 240 250
IEFLDRALPN EDADVSKEIV RQYKKLGVPI LTSTKVETVT DNGSSVTVEY
260 270 280 290 300
TGKDGARGSL EVDKVLMSIG FAPNVEGFGL ENTGVALTDR GAIAIDDHMR
310 320 330 340 350
TNVEHIYAIG DVTAKLMLAH VAEAQGVVAS ETIAGAETVM LGDYRMMPRA
360 370 380 390 400
TFCQPQVASF GLTEAQAREE GHDIKVAKFP FTANGKAHGL GDPNGFVKLI
410 420 430 440 450
SDTKYGELLG GHLIGPDVSE LLPELTLAQK WDLTALELAR NVHTHPTLSE
460
ALQEAIHGLA GHMINL
Length:466
Mass (Da):49,796
Last modified:December 4, 2007 - v1
Checksum:iFAFE7B7C68F0498C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000820 Genomic DNA. Translation: ABW14830.1.
RefSeqiWP_020462938.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW14830; ABW14830; Franean1_5475.
KEGGifre:Franean1_5475.
PATRICi21944344. VBIFraSp51419_5775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000820 Genomic DNA. Translation: ABW14830.1.
RefSeqiWP_020462938.1. NC_009921.1.

3D structure databases

ProteinModelPortaliA8L4L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi298653.Franean1_5475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW14830; ABW14830; Franean1_5475.
KEGGifre:Franean1_5475.
PATRICi21944344. VBIFraSp51419_5775.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiCSDGMTK.
OrthoDBiPOG091H0239.

Enzyme and pathway databases

BioCyciFSP298653:GHPI-5402-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8L4L5_FRASN
AccessioniPrimary (citable) accession number: A8L4L5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.