A8L3U5 (SYR_FRASN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	Franean1_1004

Organism

Frankia sp. (strain EAN1pec) [Complete proteome] [HAMAP]

Taxonomic identifier

298653 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm By similarity HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 570	570	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000095365
Regions
	Motif	129 – 139	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A8L3U5 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: F8B42D7448947B57	FASTA	570	60,724
	10 20 30 40 50 60 MTPAELADTI VAAVRAAVAN GDLEVAVPDS VTVERPRQPE HGDYASPVAL QLAKAARRRP 70 80 90 100 110 120 REVAELLAAR LRAEAGVAEV EVAGPGFLNI RLAGAALGGI ARRIVRDGES YGRAAVSQGV 130 140 150 160 170 180 RVNLEFVSAN PTGPVTLASA RWAAVGDALS RVFAAAGYEV GTEYYVNDAG VQVERFGASV 190 200 210 220 230 240 LAALRGQPAP ADGYQGAYVA EIAAKVLAAN PALEQLLAAS GGEQDSGAEQ DKALAVCARD 250 260 270 280 290 300 GVELMLAEIR ATLSGFGVEY DLWKSERSLH EAGELIAAID ELRTQGHVYE AGGAVWLRTT 310 320 330 340 350 360 DFGDDKDRAL IKSDGRPTYF CADAAYYRDK RRRGFDRLCY LLGADHHGYI GRLKAISACF 370 380 390 400 410 420 GDDPDHNLDV LIGQMVTLSR GGVAVKMSKR AGNFLTLHDL VDAVGVDAAR YSLVRASMDS 430 440 450 460 470 480 ALDLDLDAIA RQTNDNPVFY VQYAHARISS LIRNAAALGL ATSADPAFDV DGVDVSLLTH 490 500 510 520 530 540 PREVDLLGAL GELPRVVESA AELRAPHRIA RYLEELAGTY HRFYDSCRVL PQGDEEPTAI 550 560 570 TAARLLLAEA TRTVLANGLR LLGVSAPERM

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EAN1pec.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000820 Genomic DNA. Translation: ABW10460.1.
RefSeq	YP_001505366.1. NC_009921.1.
3D structure databases
ProteinModelPortal	A8L3U5.
ModBase	Search...
Protein-protein interaction databases
STRING	A8L3U5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5669418.
GenomeReviews	Gene locus Franean1_1004 in contig CP000820_GR.
KEGG	fre:Franean1_1004.
PATRIC	21934842. VBIFraSp51419_1040.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695395.
OMA	FDVYFHE.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	FSP1855:FRANEAN1_1004-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_FRASN

Accession

Primary (citable) accession number: A8L3U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program