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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Frankia sp. (strain EAN1pec)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20ZincUniRule annotation1
Metal bindingi23ZincUniRule annotation1
Metal bindingi156ZincUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:Franean1_0865
OrganismiFrankia sp. (strain EAN1pec)
Taxonomic identifieri298653 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001313 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001871 – 3051D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST305

Interactioni

Protein-protein interaction databases

STRINGi298653.Franean1_0865.

Structurei

3D structure databases

ProteinModelPortaliA8L1A5.
SMRiA8L1A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiKFYWTVT.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiView protein in InterPro
IPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiView protein in Pfam
PF02585. PIG-L. 1 hit.
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

A8L1A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSAETVLP PRRVLFVHAH PDDEVISTGV TMASYAARPD THVTLVTCTL
60 70 80 90 100
GEVGEVLVPE LINLRSDLGD QLGGYRIGEL DRSCAELGVT DHRFLGGAGR
110 120 130 140 150
WRDSGMIDTP ANDDPRCLWR ADLDEASAAL VQVVREVRPQ VLVTYDENGA
160 170 180 190 200
YGHPDHIRAH DVSVRAFADA ANPDFAPEAG QPWQISKFYE TATPKSFVQA
210 220 230 240 250
GIEYFRESGG ESPFGPAESA DDIPLAVPDE LITTEIQADE YLPAKVAAMR
260 270 280 290 300
AHRTQMAVDG FFFALADGIG KRAWAAEHFV LTRGERGPGT EPGAHETDLF

AGLPL
Length:305
Mass (Da):33,078
Last modified:December 4, 2007 - v1
Checksum:i6A764F7F555E0B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000820 Genomic DNA. Translation: ABW10321.1.
RefSeqiWP_020458512.1. NC_009921.1.

Genome annotation databases

EnsemblBacteriaiABW10321; ABW10321; Franean1_0865.
KEGGifre:Franean1_0865.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMSHB_FRASN
AccessioniPrimary (citable) accession number: A8L1A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 4, 2007
Last modified: June 7, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families