Skip Header

Contribute Send feedback
Read comments (?) or add your own

A8L0K9 (DXS_FRASN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:Franean1_5184
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP]
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length650 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6506501-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_1000115743

Sequences

Sequence LengthMass (Da)Tools
A8L0K9 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 687A06DCED88165A

FASTA65069,351
        10         20         30         40         50         60 
MSLLSTIDSP QDVKRLDHEE LVTLAAEIRD FLIHAVARTG GHLGPNLGAV ELTLAIHRVF 

        70         80         90        100        110        120 
DSPFDRVLWD TGHQSYVHKI LTGRREQFDR LRQRGGLSGY PSQAESEHDI IENSHASTAL 

       130        140        150        160        170        180 
SYADGLSRAY ELRGENRAVV AVVGDGALTG GMCWEALNNI AASDRQVVIV VNDNGRSYSP 

       190        200        210        220        230        240 
TIGGLADHLA SLRLAPEYEQ VLDVVKQVLG RTPLVGAPLF DALHGIKKGI KDVVTPQGMF 

       250        260        270        280        290        300 
EDLGLKYVGP VDGHDVVAME SALRRAKDFG GPVIVHAMTR KGFGYPAAEQ DDADNFHAVG 

       310        320        330        340        350        360 
VIDPVTGKPK SASKGTTWTS IFSEEIVRIG SERPDVVTMT AAMLQPVGLK SFAKAFPDRV 

       370        380        390        400        410        420 
FDVGIAEQHA VTSAAGLAMG GLKPVVCIYA TFLNRAFDQV LMDVAMHRQP VTFVLDRAGI 

       430        440        450        460        470        480 
TGEDGASHNG MWDMSFLQVV PGLAIAAPRD AATLRAELDE AVSNTDGPTV VRYPKGKVAA 

       490        500        510        520        530        540 
DSPAIDQVGG VDVLYRAPAA ARHREVLLVS IGAMAPTCLD VAERVASQGI GITVVDPRWV 

       550        560        570        580        590        600 
KPLDPALVDL ARDHDLVVTV EDNGRVGGVG ACVAQLLRDA DVDVPVREFG VAQRFLDHGK 

       610        620        630        640        650 
RDDVLAEVGL APQDLARKVI EAVAKRQHAL MGDEVGADES NQTPAGGGQA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW14542.1.
RefSeqYP_001509448.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8L0K9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8L0K9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5673518.
GenomeReviewsGene locus Franean1_5184 in contig CP000820_GR.
KEGGfre:Franean1_5184.
PATRIC21943672. VBIFraSp51419_5442.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG571647.
OMAQYDISYM.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycFSP1855:FRANEAN1_5184-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR001017. DH_E1.
IPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_FRASN
AccessionPrimary (citable) accession number: A8L0K9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents