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A8L0K0 (A8L0K0_FRASN) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP MF_00218
Short name=UPD HAMAP MF_00218
Short name=URO-D HAMAP MF_00218
EC=4.1.1.37 HAMAP MF_00218
Gene names
Name:hemE HAMAP MF_00218
Ordered Locus Names:Franean1_5175
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW14533.1
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP MF_00218

Ontologies

Keywords
   Biological processPorphyrin biosynthesis HAMAP MF_00218
   Cellular componentCytoplasm HAMAP MF_00218
   Molecular functionDecarboxylase HAMAP MF_00218
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region46 – 505Substrate binding By similarity HAMAP MF_00218

Sites

Binding site951Substrate By similarity HAMAP MF_00218
Binding site1701Substrate By similarity HAMAP MF_00218
Binding site2251Substrate By similarity HAMAP MF_00218
Binding site3391Substrate By similarity HAMAP MF_00218
Site951Transition state stabilizer By similarity HAMAP MF_00218

Sequences

Sequence LengthMass (Da)Tools
A8L0K0 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 0B9A56CABA29A7C1

FASTA36038,054
        10         20         30         40         50         60 
MSLGSTAVAP PRPGVSPRRP GLAATSPFLR AAAGDRPDSV PVWFMRQAGR VLPEYRALRA 

        70         80         90        100        110        120 
TTAMLDSCRN ADMVTEITLQ PVRRFRPDAA IFFSDIVLPL AAVGVDVDIV AGVGPVVAHP 

       130        140        150        160        170        180 
VRAPSDLDVL RPLEPGDVPY VSEAVASLVR ELGQTPLIGF AGAPFTLASY LIEGGPSRNH 

       190        200        210        220        230        240 
TRTKALMYAE PALWHDLLGR LADITAAFLR VQVDAGADAI QLFDSWAGAL SEDDYLRYVA 

       250        260        270        280        290        300 
PHSTRVLAAF ADDGIPRIHF GVNTGELLGA MGAAGADVVG VDWRVPLDEA ARRVGPGRAV 

       310        320        330        340        350        360 
QGNLDPAAVF APSDVLAAKV RDVCRRGAAA PGHIFNFGHG VLPESDPGVL AHIVDLVHQF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW14533.1.
RefSeqYP_001509439.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8L0K0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8L0K0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5673509.
GenomeReviewsGene locus Franean1_5175 in contig CP000820_GR.
KEGGfre:Franean1_5175.
PATRIC21943652. VBIFraSp51419_5432.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO_D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8L0K0_FRASN
AccessionPrimary (citable) accession number: A8L0K0
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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