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A8KZA3 (A8KZA3_FRASN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
EC=6.3.2.9 HAMAP MF_00639
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639
Ordered Locus Names:Franean1_5100
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW14459.1
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential EMBL ABW14459.1
Chain34 – 526493 Potential EMBL ABW14459.1
PRO_5000280229

Regions

Nucleotide binding126 – 1327ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
A8KZA3 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: FCC671662DBB3BC9

FASTA52652,541
        10         20         30         40         50         60 
MSTSATPVLA GAVLAGAQVT VVGVGVSGAA AAGALAARGA RVVVVDAADG PGQRAAAERL 

        70         80         90        100        110        120 
RAEGIEVRLG GLPAEAGAAS LVVTSPGVPP HTPLLRAAEA AGVPVWGEVE LAWRWRGLSR 

       130        140        150        160        170        180 
WLAVTGTNGK TTTTEMLGAM LVAGGRRATT AGNIGTPIVA AVETRPPYDA LAVELSSFQL 

       190        200        210        220        230        240 
HYTSTVAPRA AVILNVAPDH LDWHGGADAY AAAKARIWAA PHTVAVGNVD DPVSLELLSR 

       250        260        270        280        290        300 
APGRRVTFGL DPNATPRPDL TVVNGYLVDR VFSGGRLIAV ADLGAAGRSP GRRPPATGIT 

       310        320        330        340        350        360 
GGGPAGGRVG GAVAGGARAG AAGTGDGPGP FGGGQFRDDR FPAFATGAEL GSHNIANALA 

       370        380        390        400        410        420 
AAALARADGV DPAAIGAALA SFRPGAHRNV TVGRRGGVRY VDDSKATNPH AAAASLRAYP 

       430        440        450        460        470        480 
SVVWIAGGLN KGLEFDDLVV SARRGLRAVV LIGQCADEVA AALARHAPDV PVERAAGMDD 

       490        500        510        520 
AVDAAAKLAA PGDTVLLAPA AASMDMFRDY AERGDLFAAA VRARGG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW14459.1.
RefSeqYP_001509365.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8KZA3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8KZA3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5673435.
GenomeReviewsGene locus Franean1_5100 in contig CP000820_GR.
KEGGfre:Franean1_5100.
PATRIC21943454. VBIFraSp51419_5337.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBPRK01438.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 2 hits.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PF00070. Pyr_redox. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8KZA3_FRASN
AccessionPrimary (citable) accession number: A8KZA3
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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