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A8KZ21 (A8KZ21_FRASN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:Franean1_3540
OrganismFrankia sp. (strain EAN1pec) [Complete proteome] [HAMAP] EMBL ABW12941.1
Taxonomic identifier298653 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length766 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6491Zinc By similarity HAMAP MF_00172
Metal binding6511Zinc By similarity HAMAP MF_00172
Metal binding7341Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
A8KZ21 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: DAA42725CA532311

FASTA76682,697
        10         20         30         40         50         60 
MVSTTVAGYP RIGPARELKT TTEAYWADRL GEDELVWIAQ QLRADVWKDL AAAGLDAIPS 

        70         80         90        100        110        120 
NTFSFYDQVL DTAVLFDAVP DRFRGLTGAG GSPATPLETY FAMARGADGV APLEMTKWFD 

       130        140        150        160        170        180 
TNYHYLVPEL DPSTRFRLVG DKPLREVREA RELGVETRPV LVGPVTFLLL AKAAAGAPAG 

       190        200        210        220        230        240 
FRPLDLLDDL VGQYVELLDD LASDSVAWVQ LDEPALTRDL TPAELAATAR AYARLGGATT 

       250        260        270        280        290        300 
RPRILVSTFF GEAGEALPVL RDAPIDGIGL DLVAGPGNLD AVARAGGVGA KTLFVGVVNG 

       310        320        330        340        350        360 
HNVWRADLPA ALATCATLSG LAADVVVTTS CSLLHVPIDV EAETNLDPRL ADRMAFARQK 

       370        380        390        400        410        420 
VEEVVLLGTA LRAGRDAVAA EIAAAEARRL AVPDQLVDPR VRERLAALGE GWPTRGDLEH 

       430        440        450        460        470        480 
RVEAQAAALG LPPLPTTTIG SFPQTAAIRA ARASRRAGTL DEAGYVRAMK TEIDQVVALQ 

       490        500        510        520        530        540 
EDIGLDVLVH GEPERNDMVQ YFAELLAGYA ATEHGWVQSY GTRYVRPPIL FGDVSRPEPM 

       550        560        570        580        590        600 
TLRWAAYAQS RTSRPVKGML TGPVTMLAWS FVRDDQPLEV TARQVALALR DEIHGLEAAG 

       610        620        630        640        650        660 
IRIIQVDEPA LRELLPPRRA LWGAYLDWAV GAFRLATSSV AASTQIHTHM CYSEFGDIIG 

       670        680        690        700        710        720 
SIDDLDADVA SVEAARSRME LVTDLRKAGY RRAIGPGVYD IHSPRVPTVD EIEKSLRLAL 

       730        740        750        760 
AAVEPARLWA NPDCGLKTRS FTEVEPALRN MVTATRRVRE SLPDGG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000820 Genomic DNA. Translation: ABW12941.1.
RefSeqYP_001507847.1. NC_009921.1.

3D structure databases

ProteinModelPortalA8KZ21.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8KZ21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5671910.
GenomeReviewsGene locus Franean1_3540 in contig CP000820_GR.
KEGGfre:Franean1_3540.
PATRIC21940077. VBIFraSp51419_3648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA8KZ21_FRASN
AccessionPrimary (citable) accession number: A8KZ21
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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