A8KJ33 (A8KJ33_BURPS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase 1 HAMAP MF_01023
EC=2.6.1.9 HAMAP MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase 1 HAMAP MF_01023

Gene names

Name:	hisC EMBL EDO91152.1
Synonyms:	hisC1 HAMAP MF_01023
ORF Names:	BURPSPAST_Z0369 EMBL EDO91152.1

Organism

Burkholderia pseudomallei Pasteur 52237 EMBL EDO91152.1

Taxonomic identifier

331978 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023 SAAS SAAS005861
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023 SAAS SAAS005861
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023 SAAS SAAS005861
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP MF_01023 SAAS SAAS005861
Ligand	Pyridoxal phosphate HAMAP MF_01023 SAAS SAAS005861
Molecular function	Aminotransferase HAMAP MF_01023 SAAS SAAS005861 EMBL EDO91152.1 Transferase
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	213	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_01023

Sequences

	Sequence		Length	Mass (Da)
	A8KJ33 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 2552F2D2AFA5C806	FASTA	356	39,286
	10 20 30 40 50 60 MSRYWSDIVR QLEPYVPGEQ PALAHPVKLN TNENPYPPSP RALDAIRREL GDTGEALRRY 70 80 90 100 110 120 PDPVARRLRE TVAAYHGIAP EQVFAGNGSD EVLAHAFQAL LQHDRPLRFP DITYSFYPTY 130 140 150 160 170 180 ARLYRVAYET VPLADDFSIV VDDYLDDAGC VLFPNPNAPT GRALPLADIE RIVAANPSSV 190 200 210 220 230 240 VVIDEAYVDF GAESAVSLIA RYPNLLVVHT VSKARSLAGM RVGFAFGDAA LIDALTRVKD 250 260 270 280 290 300 SFNSYPLDRL AQVATQASYE DEAWFQATRK QVIASRERLV GALAALGFDV VPSAANFVFA 310 320 330 340 350 RPRSHDAATL AAQLKQREIF VRHFKLPRID QHLRITVGSD AECDALVAAL RELLAA

References

[1]	"Annotation of Burkholderia pseudomallei Pasteur 52237." DeShazer D., Woods D.E., Nierman W.C. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Pasteur 52237 EMBL EDO91152.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH899746 Genomic DNA. Translation: EDO91152.1.
3D structure databases
ProteinModelPortal	A8KJ33.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	30402019. VBIBurPse100884_2643.
Phylogenomic databases
OMA	MRGELND.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8KJ33_BURPS

Accession

Primary (citable) accession number: A8KJ33

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)