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A8KBY2

- BRF2_DANRE

UniProt

A8KBY2 - BRF2_DANRE

Protein

Transcription factor IIIB 50 kDa subunit

Gene

brf2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51ZincBy similarity
    Metal bindingi8 – 81ZincBy similarity
    Metal bindingi26 – 261ZincBy similarity
    Metal bindingi29 – 291ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 3434TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor IIIB 50 kDa subunit
    Alternative name(s):
    B-related factor 2
    Short name:
    BRF-2
    Gene namesi
    Name:brf2
    ORF Names:zgc:100856
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040801-43. brf2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Transcription factor IIIB 50 kDa subunitPRO_0000337191Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000006590.

    Structurei

    3D structure databases

    ProteinModelPortaliA8KBY2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati171 – 245752Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.Curated
    Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 3434TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG288872.
    HOGENOMiHOG000095260.
    HOVERGENiHBG107537.
    InParanoidiQ6DC40.
    KOiK15197.
    PhylomeDBiA8KBY2.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8KBY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKNCPECGS SRVVEDDLYS QKQWVCEDCG SVVSEGLLTT TLSEESHSRA    50
    VPFFTSTAAF KKPCRNLVSG FSRLRALCRI FRLSSSMEDA SANLFERAYN 100
    HPNFLHISLS KKQILAGCCM FHICRQNSWP VFMGTIGYLL DADNYQMGTI 150
    YQELTKSLNL QTTQVCITRM LESFCYDFKL APDEVEEVFS VAQQRLVDQT 200
    SALLELAADT WILTGRRPFP LFLAAVYVAW QSLNPLARMK YSLMKFCKIA 250
    KAPEQLWCKS KDTINKRLNE LLEVLCKLGR ELPWVRPTDI QMNTVTTLVE 300
    DILKHRKALL ILAVKHYEKQ LEETQTSQYS ESELSDSKSS VQTQCKSPPD 350
    EEDEGCELPP DHWGKRHLFL PPCVRTQKRQ KINEAPLEVT GDEDISDSEI 400
    ESYIRSEEEI KLFAKARKKI CKY 423
    Length:423
    Mass (Da):48,439
    Last modified:December 4, 2007 - v1
    Checksum:iB646E7B231C6BA0F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti312 – 3121L → M in AAH78247. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078247 mRNA. Translation: AAH78247.1.
    BC154287 mRNA. Translation: AAI54288.1.
    RefSeqiNP_001003536.1. NM_001003536.1.
    UniGeneiDr.80848.

    Genome annotation databases

    GeneIDi445142.
    KEGGidre:445142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078247 mRNA. Translation: AAH78247.1 .
    BC154287 mRNA. Translation: AAI54288.1 .
    RefSeqi NP_001003536.1. NM_001003536.1.
    UniGenei Dr.80848.

    3D structure databases

    ProteinModelPortali A8KBY2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000006590.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 445142.
    KEGGi dre:445142.

    Organism-specific databases

    CTDi 55290.
    ZFINi ZDB-GENE-040801-43. brf2.

    Phylogenomic databases

    eggNOGi NOG288872.
    HOGENOMi HOG000095260.
    HOVERGENi HBG107537.
    InParanoidi Q6DC40.
    KOi K15197.
    PhylomeDBi A8KBY2.

    Miscellaneous databases

    NextBioi 20831905.
    PROi A8KBY2.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiBRF2_DANRE
    AccessioniPrimary (citable) accession number: A8KBY2
    Secondary accession number(s): Q6DC40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3