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A8KBY2 (BRF2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor IIIB 50 kDa subunit
Alternative name(s):
B-related factor 2
Short name=BRF-2
Gene names
Name:brf2
ORF Names:zgc:100856
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA-templated transcription, initiation

Inferred from electronic annotation. Source: InterPro

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Transcription factor IIIB 50 kDa subunit
PRO_0000337191

Regions

Repeat171 – 245752
Zinc finger1 – 3434TFIIB-type

Sites

Metal binding51Zinc By similarity
Metal binding81Zinc By similarity
Metal binding261Zinc By similarity
Metal binding291Zinc By similarity

Experimental info

Sequence conflict3121L → M in AAH78247. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A8KBY2 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: B646E7B231C6BA0F

FASTA42348,439
        10         20         30         40         50         60 
MSKNCPECGS SRVVEDDLYS QKQWVCEDCG SVVSEGLLTT TLSEESHSRA VPFFTSTAAF 

        70         80         90        100        110        120 
KKPCRNLVSG FSRLRALCRI FRLSSSMEDA SANLFERAYN HPNFLHISLS KKQILAGCCM 

       130        140        150        160        170        180 
FHICRQNSWP VFMGTIGYLL DADNYQMGTI YQELTKSLNL QTTQVCITRM LESFCYDFKL 

       190        200        210        220        230        240 
APDEVEEVFS VAQQRLVDQT SALLELAADT WILTGRRPFP LFLAAVYVAW QSLNPLARMK 

       250        260        270        280        290        300 
YSLMKFCKIA KAPEQLWCKS KDTINKRLNE LLEVLCKLGR ELPWVRPTDI QMNTVTTLVE 

       310        320        330        340        350        360 
DILKHRKALL ILAVKHYEKQ LEETQTSQYS ESELSDSKSS VQTQCKSPPD EEDEGCELPP 

       370        380        390        400        410        420 
DHWGKRHLFL PPCVRTQKRQ KINEAPLEVT GDEDISDSEI ESYIRSEEEI KLFAKARKKI 


CKY 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC078247 mRNA. Translation: AAH78247.1.
BC154287 mRNA. Translation: AAI54288.1.
RefSeqNP_001003536.1. NM_001003536.1.
UniGeneDr.80848.

3D structure databases

ProteinModelPortalA8KBY2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000006590.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID445142.
KEGGdre:445142.

Organism-specific databases

CTD55290.
ZFINZDB-GENE-040801-43. brf2.

Phylogenomic databases

eggNOGNOG288872.
HOGENOMHOG000095260.
HOVERGENHBG107537.
InParanoidQ6DC40.
KOK15197.
PhylomeDBA8KBY2.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20831905.
PROA8KBY2.

Entry information

Entry nameBRF2_DANRE
AccessionPrimary (citable) accession number: A8KBY2
Secondary accession number(s): Q6DC40
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families