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Protein

Putative sodium-coupled neutral amino acid transporter 11

Gene

slc38a11

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 11
Alternative name(s):
Solute carrier family 38 member 11
Gene namesi
Name:slc38a11
ORF Names:zgc:110221
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-050417-122. slc38a11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Topological domaini43 – 519ExtracellularSequence Analysis
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 9321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 14228ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 1641CytoplasmicSequence Analysis
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 19914ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Topological domaini221 – 24525CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Topological domaini267 – 28519ExtracellularSequence AnalysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence AnalysisAdd
BLAST
Topological domaini307 – 32317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence AnalysisAdd
BLAST
Topological domaini345 – 3451ExtracellularSequence Analysis
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Topological domaini367 – 38822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence AnalysisAdd
BLAST
Topological domaini410 – 44839ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Putative sodium-coupled neutral amino acid transporter 11PRO_0000326062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiA8KBL5.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112271.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
HOVERGENiHBG106990.
InParanoidiA8KBL5.
KOiK14997.
OMAiRWFQGEN.
OrthoDBiEOG7SBNNK.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8KBL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESERSCLLS SHDAGKGGSS SVSSASFNFI NSIIGSGIIG LPYSMSQAGL
60 70 80 90 100
PMGLLLLILV AFITDYSIIL LVRGGNLSGT HSYQSLVRST FGQIGYIIVS
110 120 130 140 150
VLQFLYPFIA MISYNIIAGD TLTKVFMRIP GVGPGNILTE RHFVIAMSTV
160 170 180 190 200
LFTLPLSLYR DIAKLGKVSL LSMILTFGIL MTVVVRAATL GPQIPASDDA
210 220 230 240 250
WVFARWNAIQ AVAVMSFALI CHHNSFMIYG SLQEPTLSRW SLVTHISVGS
260 270 280 290 300
SVLVSAVFAA AGYATFTVYT QGDIFENYCR SDNLATFGRF CYGVSIITTF
310 320 330 340 350
PLECFVTREV ISNALFKGGE LSKSSHVIIT LVIISATTAI SLSYDCLGIV
360 370 380 390 400
LELNGILSAV PLMFIFPSAC FLKLSNERWC RGENLIASMI LVAGVFVMII
410 420 430 440
GLIMMALFPQ DCSHGAEMFY CSASNTSSTA SPSNILQFIN TTQNTSIV
Length:448
Mass (Da):48,300
Last modified:March 18, 2008 - v2
Checksum:i8A9A031D52A17224
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111M → V in AAH92805 (Ref. 1) Curated
Sequence conflicti332 – 3321V → G in AAH92805 (Ref. 1) Curated
Sequence conflicti342 – 3421L → P in AAH92805 (Ref. 1) Curated
Sequence conflicti426 – 4261T → I in AAI54163 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092805 mRNA. Translation: AAH92805.1.
BC154162 mRNA. Translation: AAI54163.1.
RefSeqiNP_001017644.1. NM_001017644.1.
UniGeneiDr.151480.

Genome annotation databases

GeneIDi550337.
KEGGidre:550337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092805 mRNA. Translation: AAH92805.1.
BC154162 mRNA. Translation: AAI54163.1.
RefSeqiNP_001017644.1. NM_001017644.1.
UniGeneiDr.151480.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112271.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi550337.
KEGGidre:550337.

Organism-specific databases

CTDi151258.
ZFINiZDB-GENE-050417-122. slc38a11.

Phylogenomic databases

eggNOGiCOG0814.
HOVERGENiHBG106990.
InParanoidiA8KBL5.
KOiK14997.
OMAiRWFQGEN.
OrthoDBiEOG7SBNNK.
TreeFamiTF328787.

Miscellaneous databases

NextBioi20879594.
PROiA8KBL5.

Gene expression databases

BgeeiA8KBL5.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Ovary.

Entry informationi

Entry nameiS38AB_DANRE
AccessioniPrimary (citable) accession number: A8KBL5
Secondary accession number(s): Q568L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 22, 2015
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.