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A8KBL5 (S38AB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative sodium-coupled neutral amino acid transporter 11
Gene names
Name:slc38a11
ORF Names:zgc:110221
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative sodium-dependent amino acid/proton antiporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
   Biological processAmino-acid transport
Ion transport
Sodium transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processamino acid transport

Inferred from electronic annotation. Source: UniProtKB-KW

sodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Putative sodium-coupled neutral amino acid transporter 11
PRO_0000326062

Regions

Topological domain1 – 2121Cytoplasmic Potential
Transmembrane22 – 4221Helical; Potential
Topological domain43 – 519Extracellular Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 9321Cytoplasmic Potential
Transmembrane94 – 11421Helical; Potential
Topological domain115 – 14228Extracellular Potential
Transmembrane143 – 16321Helical; Potential
Topological domain1641Cytoplasmic Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 19914Extracellular Potential
Transmembrane200 – 22021Helical; Potential
Topological domain221 – 24525Cytoplasmic Potential
Transmembrane246 – 26621Helical; Potential
Topological domain267 – 28519Extracellular Potential
Transmembrane286 – 30621Helical; Potential
Topological domain307 – 32317Cytoplasmic Potential
Transmembrane324 – 34421Helical; Potential
Topological domain3451Extracellular Potential
Transmembrane346 – 36621Helical; Potential
Topological domain367 – 38822Cytoplasmic Potential
Transmembrane389 – 40921Helical; Potential
Topological domain410 – 44839Extracellular Potential

Amino acid modifications

Glycosylation4251N-linked (GlcNAc...) Potential
Glycosylation4401N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1111M → V in AAH92805. Ref.1
Sequence conflict3321V → G in AAH92805. Ref.1
Sequence conflict3421L → P in AAH92805. Ref.1
Sequence conflict4261T → I in AAI54163. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A8KBL5 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: 8A9A031D52A17224

FASTA44848,300
        10         20         30         40         50         60 
MESERSCLLS SHDAGKGGSS SVSSASFNFI NSIIGSGIIG LPYSMSQAGL PMGLLLLILV 

        70         80         90        100        110        120 
AFITDYSIIL LVRGGNLSGT HSYQSLVRST FGQIGYIIVS VLQFLYPFIA MISYNIIAGD 

       130        140        150        160        170        180 
TLTKVFMRIP GVGPGNILTE RHFVIAMSTV LFTLPLSLYR DIAKLGKVSL LSMILTFGIL 

       190        200        210        220        230        240 
MTVVVRAATL GPQIPASDDA WVFARWNAIQ AVAVMSFALI CHHNSFMIYG SLQEPTLSRW 

       250        260        270        280        290        300 
SLVTHISVGS SVLVSAVFAA AGYATFTVYT QGDIFENYCR SDNLATFGRF CYGVSIITTF 

       310        320        330        340        350        360 
PLECFVTREV ISNALFKGGE LSKSSHVIIT LVIISATTAI SLSYDCLGIV LELNGILSAV 

       370        380        390        400        410        420 
PLMFIFPSAC FLKLSNERWC RGENLIASMI LVAGVFVMII GLIMMALFPQ DCSHGAEMFY 

       430        440 
CSASNTSSTA SPSNILQFIN TTQNTSIV

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC092805 mRNA. Translation: AAH92805.1.
BC154162 mRNA. Translation: AAI54163.1.
IPIIPI00570212.
RefSeqNP_001017644.1. NM_001017644.1.
UniGeneDr.151480.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000058892; ENSDARP00000058891; ENSDARG00000040257.
ENSDART00000125269; ENSDARP00000112271; ENSDARG00000089280.
GeneID550337.
KEGGdre:550337.

Organism-specific databases

CTD151258.
ZFINZDB-GENE-050417-122. slc38a11.

Phylogenomic databases

eggNOGCOG0814.
GeneTreeENSGT00700000104173.
HOVERGENHBG106990.
InParanoidQ568L8.
KOK14997.
OrthoDBEOG4FBHT6.

Gene expression databases

BgeeA8KBL5.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20879594.

Entry information

Entry nameS38AB_DANRE
AccessionPrimary (citable) accession number: A8KBL5
Secondary accession number(s): Q568L8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 6, 2013
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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