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Protein
Submitted name:

RAP1A, member of RAS oncogene family

Gene

RAP1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
RAP1A, member of RAS oncogene familyImported
Submitted name:
Ras-related protein Rap-1AImported
Submitted name:
cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNAImported
Gene namesi
Name:RAP1AImported
ORF Names:hCG_1818872Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34217.

Expressioni

Gene expression databases

BgeeiENSG00000116473.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348786.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOVERGENiHBG009351.
KOiK04353.
OMAiARSFNSA.
OrthoDBiEOG091G0OOG.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8KAH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ
60 70 80 90 100
CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI
110 120 130 140 150
LRVKDTEDVP MILVGNKCDL EDERVVGKEQ GQNLARQWCN CAFLESSAKS
160 170 180
KINVNEIFYD LVRQINRKTP VEKKKPKKKS CLLL
Length:184
Mass (Da):20,987
Last modified:February 5, 2008 - v1
Checksum:i42C39290C98E0A92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei184Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293044 mRNA. Translation: BAF85733.1.
AB451235 mRNA. Translation: BAG70049.1.
AB451360 mRNA. Translation: BAG70174.1.
CH471122 Genomic DNA. Translation: EAW56503.1.
RefSeqiNP_001010935.1. NM_001010935.2.
NP_001278825.1. NM_001291896.1.
NP_002875.1. NM_002884.3.
XP_016857451.1. XM_017001962.1.
XP_016857452.1. XM_017001963.1.
XP_016857453.1. XM_017001964.1.
UniGeneiHs.190334.
Hs.586618.

Genome annotation databases

GeneIDi5906.
KEGGihsa:5906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293044 mRNA. Translation: BAF85733.1.
AB451235 mRNA. Translation: BAG70049.1.
AB451360 mRNA. Translation: BAG70174.1.
CH471122 Genomic DNA. Translation: EAW56503.1.
RefSeqiNP_001010935.1. NM_001010935.2.
NP_001278825.1. NM_001291896.1.
NP_002875.1. NM_002884.3.
XP_016857451.1. XM_017001962.1.
XP_016857452.1. XM_017001963.1.
XP_016857453.1. XM_017001964.1.
UniGeneiHs.190334.
Hs.586618.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348786.

Protocols and materials databases

DNASUi5906.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5906.
KEGGihsa:5906.

Organism-specific databases

CTDi5906.
PharmGKBiPA34217.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOVERGENiHBG009351.
KOiK04353.
OMAiARSFNSA.
OrthoDBiEOG091G0OOG.

Miscellaneous databases

ChiTaRSiRAP1A. human.
GenomeRNAii5906.

Gene expression databases

BgeeiENSG00000116473.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8KAH9_HUMAN
AccessioniPrimary (citable) accession number: A8KAH9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.