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Protein
Submitted name:

DnaJ (Hsp40) homolog, subfamily C, member 3

Gene

DNAJC3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
DnaJ (Hsp40) homolog, subfamily C, member 3Imported
Submitted name:
cDNA FLJ77657, highly similar to Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3), mRNAImported
Submitted name:
cDNA, FLJ93304, Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3),mRNAImported
Gene namesi
Name:DNAJC3Imported
ORF Names:hCG_28703Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501010406432 – 504Sequence analysisAdd BLAST473

Expressioni

Gene expression databases

BgeeiENSG00000102580.
ExpressionAtlasiA8KA82. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA8KA82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 373TPR_REGIONInterPro annotationAdd BLAST337
Repeati37 – 70TPRPROSITE-ProRule annotationAdd BLAST34
Repeati71 – 104TPRPROSITE-ProRule annotationAdd BLAST34
Repeati105 – 138TPRPROSITE-ProRule annotationAdd BLAST34
Repeati188 – 221TPRPROSITE-ProRule annotationAdd BLAST34
Repeati222 – 255TPRPROSITE-ProRule annotationAdd BLAST34
Repeati268 – 301TPRPROSITE-ProRule annotationAdd BLAST34
Repeati306 – 339TPRPROSITE-ProRule annotationAdd BLAST34
Repeati340 – 373TPRPROSITE-ProRule annotationAdd BLAST34
Domaini394 – 462JInterPro annotationAdd BLAST69

Keywords - Domaini

SignalSequence analysis, TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0624. Eukaryota.
COG0484. LUCA.
HOVERGENiHBG053820.
KOiK09523.
OMAiGAECGVN.
OrthoDBiEOG091G0783.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
1.25.40.10. 5 hits.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR018704. TPR_21.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PF09976. TPR_21. 1 hit.
PF13181. TPR_8. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SM00028. TPR. 7 hits.
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF48452. SSF48452. 2 hits.
PROSITEiView protein in PROSITE
PS50076. DNAJ_2. 1 hit.
PS50005. TPR. 8 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

A8KA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPGSVTSR LGSVFPFLLV LVDLQYEGAE CGVNADVEKH LELGKKLLAA
60 70 80 90 100
GQLADALSQF HAAVDGDPDN YIAYYRRATV FLAMGKSKAA LPDLTKVIQL
110 120 130 140 150
KMDFTAARLQ RGHLLLKQGK LDEAEDDFKK VLKSNPSENE EKEAQSQLIK
160 170 180 190 200
SDEMQRLRSQ ALNAFGSGDY TAAIAFLDKI LEVCVWDAEL RELRAECFIK
210 220 230 240 250
EGEPRKAISD LKAASKLKND NTEAFYKIST LYYQLGDHEL SLSEVRECLK
260 270 280 290 300
LDQDHKRCFA HYKQVKKLNK LIESAEELIR DGRYTDATSK YESVMKTEPS
310 320 330 340 350
IAEYTVRSKE RICHCFSKDE KPVEAIRVCS EVLQMEPDNV NALKDRAEAY
360 370 380 390 400
LIEEMYDEAI QDYETAQEHN ENDQQIREGL EKAQRLLKQS QKRDYYKILG
410 420 430 440 450
VKRNAKKQEI IKAYRKLALQ WHPDNFQNEE EKKKAEKKFI DIAAAKEVLS
460 470 480 490 500
DPEMRKKFDD GEDPLDAESQ QGGGGNPFHR SWNSWQGFNP FSSGGPFRFK

FHFN
Length:504
Mass (Da):57,580
Last modified:December 4, 2007 - v1
Checksum:iE720A1E7F618B912
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292947 mRNA. Translation: BAF85636.1.
AK312861 mRNA. Translation: BAG35713.1.
CH471085 Genomic DNA. Translation: EAX08959.1.
RefSeqiNP_006251.1. NM_006260.4.
UniGeneiHs.59214.

Genome annotation databases

GeneIDi5611.
KEGGihsa:5611.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA8KA82_HUMAN
AccessioniPrimary (citable) accession number: A8KA82
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.