A8K944 (A8K944_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Regulator of G-protein signalling 22, isoform CRA_a EMBL EAW91794.1

Submitted name:
Regulator of G-protein-signaling 22 Ensembl ENSP00000428212
Submitted name:
cDNA FLJ75004 EMBL BAF85248.1

Gene names

Name:	RGS22 Ensembl ENSP00000428212 EMBL EAW91794.1
ORF Names:	hCG_15692 EMBL EAW91794.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAF85248.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1252 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 3 RGS domains. RuleBase RU003298

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8K944 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: A7CB6BFD5C6F2E6E	FASTA	1,252	145,768
	10 20 30 40 50 60 MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD YGVFEVANDA 70 80 90 100 110 120 PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP DEDETINVNY NIMCLSREEG 130 140 150 160 170 180 IKWIKKERLP AFLESDCYFE YRLAKLVSQV RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA 190 200 210 220 230 240 TEEDNLASYT QTKDWFALAK QSQQTVSTFS LPCCVPYNKL KSPAISSVSE NFIFDDGVHP 250 260 270 280 290 300 RTKKDPSKTN KLISEFEEEE GEEEEVSVSL QDTPSQALLR VYLEKKQDVD ESLTMHFSTC 310 320 330 340 350 360 EEFLSSYIYF ILRGAIQQIV GKPVGETPDY INFNNITKVS FDDCFESIHG KNFLSELVQT 370 380 390 400 410 420 TKERSEEIEQ TSLSSKNESA GPESRADWCI SHRTYDIGNR KEFERFKKFI KGTLGERYWW 430 440 450 460 470 480 LWMDIERLKV LKDPGRHQRH LEKMKKCYLV SNGDYYLSAE ILSKFKLLDG SQWNEEHLRN 490 500 510 520 530 540 IQSEVLKPLL LYWAPRFCVT HSASTKYASA ELKFWHLRQA KPRKDIDPFP QMATLLPLRP 550 560 570 580 590 600 KSCIPQIPEI QKEEFSLSQP PKSPNKSPEV KTATQKPWKR ELLYPGSSKD DVIEKGSKYM 610 620 630 640 650 660 SESSKVIHLT SFTDISECLK PQLDRRYAYT EEPRVKTVSD VGALGGSDME NLLQSLYVEN 670 680 690 700 710 720 RAGFFFTKFC EHSGNKLWKN SVYFWFDLQA YHQLFYQETL QPFKVCKQAQ YLFATYVAPS 730 740 750 760 770 780 ATLDIGLQQE KKKEIYMKIQ PPFEDLFDTA EEYILLLLLE PWTKMVKSDQ IAYKKVELVE 790 800 810 820 830 840 ETRQLDSTYF RKLQALHKET FSKKAEDTTC EIGTGILSLS NVSKRTEYWD NVPAEYKHFK 850 860 870 880 890 900 FSDLLNNKLE FEHFRQFLET HSSSMDLMCW TDIEQFRRIT YRDRNQRKAK SIYIKNKYLN 910 920 930 940 950 960 KKYFFGPNSP ASLYQQNQVM HLSGGWGKIL HEQLDAPVLV EIQKHVQNRL ENVWLPLFLA 970 980 990 1000 1010 1020 SEQFAARQKI KVQMKDIAEE LLLQKAEKKI GVWKPVESKW ISSSCKIIAF RKALLNPVTS 1030 1040 1050 1060 1070 1080 RQFQRFVALK GDLLENGLLF WQEVQKYKDL CHSHCDESVI QKKITTIINC FINSSIPPAL 1090 1100 1110 1120 1130 1140 QIDIPVEQAQ KIIEHRKELG PYVFREAQMT IFGVLFKFWP QFCEFRKNLT DENIMSVLER 1150 1160 1170 1180 1190 1200 RQEYNKQKKK LAVLEDEKSG KDGIKQYANT SVPAIKTALL SDSFLGLQPY GRQPTWCYSK 1210 1220 1230 1240 1250 YIEALEQERI LLKIQEELEK KLFAGLQPLT NFKASSSTMS LKKNMSAHSS QK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL BAF85248.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC021590 Genomic DNA. No translation available. AP005356 Genomic DNA. No translation available. AK292559 mRNA. Translation: BAF85248.1. CH471060 Genomic DNA. Translation: EAW91794.1.
IPI	IPI00790815.
UniGene	Hs.120021.
3D structure databases
SMR	A8K944. Positions 840-965.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000523437; ENSP00000428212; ENSG00000132554.
UCSC	uc003yjc.1. human.
Organism-specific databases
HGNC	HGNC:24499. RGS22.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000013183.
HOVERGEN	HBG054528.
Gene expression databases
ArrayExpress	A8K944.
Family and domain databases
InterPro	IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 3 hits. [Graphical view]
SMART	SM00315. RGS. 2 hits. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 4 hits.
PROSITE	PS50132. RGS. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RGS22. human.
NextBio	35464609.

Entry information

Entry name

A8K944_HUMAN

Accession

Primary (citable) accession number: A8K944

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.