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A8K944 (A8K944_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Regulator of G-protein-signaling 22 Ensembl ENSP00000428212

cDNA FLJ75004 EMBL BAF85248.1
Gene names
Name:RGS22 Ensembl ENSP00000428212 EMBL EAW91794.1
ORF Names:hCG_15692 EMBL EAW91794.1
OrganismHomo sapiens (Human) [Reference proteome] EMBL BAF85248.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1252 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 3 RGS domains. RuleBase RU003298

Sequences

Sequence LengthMass (Da)Tools
A8K944 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: A7CB6BFD5C6F2E6E

FASTA1,252145,768
        10         20         30         40         50         60 
MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD YGVFEVANDA 

        70         80         90        100        110        120 
PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP DEDETINVNY NIMCLSREEG 

       130        140        150        160        170        180 
IKWIKKERLP AFLESDCYFE YRLAKLVSQV RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA 

       190        200        210        220        230        240 
TEEDNLASYT QTKDWFALAK QSQQTVSTFS LPCCVPYNKL KSPAISSVSE NFIFDDGVHP 

       250        260        270        280        290        300 
RTKKDPSKTN KLISEFEEEE GEEEEVSVSL QDTPSQALLR VYLEKKQDVD ESLTMHFSTC 

       310        320        330        340        350        360 
EEFLSSYIYF ILRGAIQQIV GKPVGETPDY INFNNITKVS FDDCFESIHG KNFLSELVQT 

       370        380        390        400        410        420 
TKERSEEIEQ TSLSSKNESA GPESRADWCI SHRTYDIGNR KEFERFKKFI KGTLGERYWW 

       430        440        450        460        470        480 
LWMDIERLKV LKDPGRHQRH LEKMKKCYLV SNGDYYLSAE ILSKFKLLDG SQWNEEHLRN 

       490        500        510        520        530        540 
IQSEVLKPLL LYWAPRFCVT HSASTKYASA ELKFWHLRQA KPRKDIDPFP QMATLLPLRP 

       550        560        570        580        590        600 
KSCIPQIPEI QKEEFSLSQP PKSPNKSPEV KTATQKPWKR ELLYPGSSKD DVIEKGSKYM 

       610        620        630        640        650        660 
SESSKVIHLT SFTDISECLK PQLDRRYAYT EEPRVKTVSD VGALGGSDME NLLQSLYVEN 

       670        680        690        700        710        720 
RAGFFFTKFC EHSGNKLWKN SVYFWFDLQA YHQLFYQETL QPFKVCKQAQ YLFATYVAPS 

       730        740        750        760        770        780 
ATLDIGLQQE KKKEIYMKIQ PPFEDLFDTA EEYILLLLLE PWTKMVKSDQ IAYKKVELVE 

       790        800        810        820        830        840 
ETRQLDSTYF RKLQALHKET FSKKAEDTTC EIGTGILSLS NVSKRTEYWD NVPAEYKHFK 

       850        860        870        880        890        900 
FSDLLNNKLE FEHFRQFLET HSSSMDLMCW TDIEQFRRIT YRDRNQRKAK SIYIKNKYLN 

       910        920        930        940        950        960 
KKYFFGPNSP ASLYQQNQVM HLSGGWGKIL HEQLDAPVLV EIQKHVQNRL ENVWLPLFLA 

       970        980        990       1000       1010       1020 
SEQFAARQKI KVQMKDIAEE LLLQKAEKKI GVWKPVESKW ISSSCKIIAF RKALLNPVTS 

      1030       1040       1050       1060       1070       1080 
RQFQRFVALK GDLLENGLLF WQEVQKYKDL CHSHCDESVI QKKITTIINC FINSSIPPAL 

      1090       1100       1110       1120       1130       1140 
QIDIPVEQAQ KIIEHRKELG PYVFREAQMT IFGVLFKFWP QFCEFRKNLT DENIMSVLER 

      1150       1160       1170       1180       1190       1200 
RQEYNKQKKK LAVLEDEKSG KDGIKQYANT SVPAIKTALL SDSFLGLQPY GRQPTWCYSK 

      1210       1220       1230       1240       1250 
YIEALEQERI LLKIQEELEK KLFAGLQPLT NFKASSSTMS LKKNMSAHSS QK 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of the human genome."
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H. expand/collapse author list , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"NEDO human cDNA sequencing project."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Testis EMBL BAF85248.1.
[5]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC021590 Genomic DNA. No translation available.
AP005356 Genomic DNA. No translation available.
AK292559 mRNA. Translation: BAF85248.1.
CH471060 Genomic DNA. Translation: EAW91794.1.
RefSeqNP_001273621.1. NM_001286692.1.
UniGeneHs.120021.

3D structure databases

ProteinModelPortalA8K944.
SMRA8K944. Positions 840-964.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000523437; ENSP00000428212; ENSG00000132554.
GeneID26166.
KEGGhsa:26166.
UCSCuc003yjc.1. human.

Organism-specific databases

CTD26166.
HGNCHGNC:24499. RGS22.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000013183.
HOVERGENHBG054528.

Gene expression databases

ArrayExpressA8K944.

Family and domain databases

InterProIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 3 hits.
[Graphical view]
SMARTSM00315. RGS. 2 hits.
[Graphical view]
SUPFAMSSF48097. SSF48097. 4 hits.
PROSITEPS50132. RGS. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRGS22. human.
NextBio35464609.

Entry information

Entry nameA8K944_HUMAN
AccessionPrimary (citable) accession number: A8K944
Entry history
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.