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Protein
Submitted name:

cDNA FLJ78071, highly similar to Human MHC class III complement component C6 mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ78071, highly similar to Human MHC class III complement component C6 mRNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500272221422 – 934Sequence analysisAdd BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi146 ↔ 164PROSITE-ProRule annotation
Disulfide bondi158 ↔ 173PROSITE-ProRule annotation
Disulfide bondi672 ↔ 699PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiA8K8Z4
PRIDEiA8K8Z4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 522MACPFInterPro annotationAdd BLAST347
Domaini642 – 701SushiInterPro annotationAdd BLAST60
Domaini702 – 763SushiInterPro annotationAdd BLAST62
Domaini785 – 839Kazal-likeInterPro annotationAdd BLAST55
Domaini881 – 934Kazal-likeInterPro annotationAdd BLAST54

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IDXP Eukaryota
ENOG410YJ70 LUCA
HOVERGENiHBG005366

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 3 hits
InterProiView protein in InterPro
IPR037563 Complement_C6
IPR003884 FacI_MAC
IPR002350 Kazal_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR19325:SF23 PTHR19325:SF23, 1 hit
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00084 Sushi, 2 hits
PF00090 TSP_1, 3 hits
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00057 FIMAC, 2 hits
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 3 hits
SUPFAMiSSF57424 SSF57424, 1 hit
SSF57535 SSF57535, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 2 hits
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50923 SUSHI, 2 hits
PS50092 TSP1, 3 hits

Sequencei

Sequence statusi: Complete.

A8K8Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRSVLYFI LLNALINKGQ ACFCDHYAWT QWTSCSKTCN SGTQSRHRQI
60 70 80 90 100
VVDKYYQENF CEQICSKQET RECNWQRCPI NCLLGDFGPW SDCDPCIEKQ
110 120 130 140 150
SKVRSVLRPS QFGGQPCTEP LVAFQPCIPS KLCKIEEADC KNKFRCDSGR
160 170 180 190 200
CIARKLECNG ENDCGDNSDE RDCGRTKAVC TRKYNPIPSV QLMGNGFHFL
210 220 230 240 250
AGEPRGEVLD NSFTGGICKT VKSSRTSNPY RVPANLENVG FEVQTAEDDL
260 270 280 290 300
KTDFYKDLTS LGHNENQQGS FSSQGGSSFS VPIFYSSKRS ENINHNSAFK
310 320 330 340 350
QAIQASHKKD SSFIRIHKVM KVLNFTTKAK DLHLSDVFLK ALNHLPLEYN
360 370 380 390 400
SALYSRIFDD FGTHYFTSGS LGGVYDLLYQ FSSEELKNSG LTEEEAKHCV
410 420 430 440 450
RIETKKRVLF AKKTKVEHRC TTNKLSEKHE GSFIQGAEKS ISLIRGGRSE
460 470 480 490 500
YGAALAWEKG SSGLEEKTFS EWLESVKENP AVIDFELAPI VDLVRNIPCA
510 520 530 540 550
VTKRNNLRKA LQEYAAKFDP CQCAPCPNNG RPTLSGTECL CVCQSGTYGE
560 570 580 590 600
NCEKQSPDYK SNAVDGQWGC WSSWSTCDAT YKRSRTRECN NPAPQRGGKR
610 620 630 640 650
CEGEKRQEED CTFSIMENNG QPCINDDEEM KEVDLPEIEA DSGCPQPVPP
660 670 680 690 700
ENGFIRNEKQ LYLVGEDVEI SCLTGFETVG YQYFRCLPDG TWRQGDVECQ
710 720 730 740 750
RTECIKPVVQ EALTITPFQR LYRIGESIEL TCPKGFVVAG PSGYTCQGNS
760 770 780 790 800
WTPPISNSLT CEKDTLTKLK GHCQLGQKQS GSECICMSPE EDCSHHSEDL
810 820 830 840 850
CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG RQLEWGLERT
860 870 880 890 900
RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM
910 920 930
GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA
Length:934
Mass (Da):104,717
Last modified:December 4, 2007 - v1
Checksum:i85CFA95B89FB9F90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292509 mRNA Translation: BAF85198.1
UniGeneiHs.481992

Similar proteinsi

Entry informationi

Entry nameiA8K8Z4_HUMAN
AccessioniPrimary (citable) accession number: A8K8Z4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health