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A8K8V0

- ZN785_HUMAN

UniProt

A8K8V0 - ZN785_HUMAN

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Protein

Zinc finger protein 785

Gene

ZNF785

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 785
Gene namesi
Name:ZNF785
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:26496. ZNF785.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Zinc finger protein 785PRO_0000345630Add
BLAST

Proteomic databases

PaxDbiA8K8V0.
PRIDEiA8K8V0.

PTM databases

PhosphoSiteiA8K8V0.

Expressioni

Gene expression databases

BgeeiA8K8V0.
CleanExiHS_ZNF785.
ExpressionAtlasiA8K8V0. baseline and differential.
GenevestigatoriA8K8V0.

Interactioni

Protein-protein interaction databases

BioGridi126995. 1 interaction.
IntActiA8K8V0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA8K8V0.
SMRiA8K8V0. Positions 144-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10072KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8K8V0.
KOiK09228.
OMAiDCSLRFA.
PhylomeDBiA8K8V0.
TreeFamiTF337922.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A8K8V0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPLAPRPA HVPGEAGPRR TRESRPGAVS FADVAVYFSP EEWECLRPAQ
60 70 80 90 100
RALYRDVMRE TFGHLGALGF SVPKPAFISW VEGEVEAWSP EAQDPDGESS
110 120 130 140 150
AAFSRGQGQE AGSRDGNEEK ERLKKCPKQK EVAHEVAVKE WWPSVACPEF
160 170 180 190 200
CNPRQSPMNP WLKDTLTRRL PHSCPDCGRN FSYPSLLASH QRVHSGERPF
210 220 230 240 250
SCGQCQARFS QRRYLLQHQF IHTGEKPYPC PDCGRRFRQR GSLAIHRRAH
260 270 280 290 300
TGEKPYACSD CKSRFTYPYL LAIHQRKHTG EKPYSCPDCS LRFAYTSLLA
310 320 330 340 350
IHRRIHTGEK PYPCPDCGRR FTYSSLLLSH RRIHSDSRPF PCVECGKGFK
360 370 380 390 400
RKTALEAHRW IHRSCSERRA WQQAVVGRSE PIPVLGGKDP PVHFRHFPDI

FQECG
Length:405
Mass (Da):46,168
Last modified:December 4, 2007 - v1
Checksum:i521391E814B117F0
GO
Isoform 2 (identifier: A8K8V0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-112: Missing.

Note: No experimental confirmation available.

Show »
Length:390
Mass (Da):44,705
Checksum:iE490E652E9A91709
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei98 – 11215Missing in isoform 2. 1 PublicationVSP_034965Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056692 mRNA. Translation: BAB71256.1.
AK292465 mRNA. Translation: BAF85154.1.
CH471192 Genomic DNA. Translation: EAW52231.1.
BC040642 mRNA. Translation: AAH40642.1.
CCDSiCCDS10685.1. [A8K8V0-1]
RefSeqiNP_689671.2. NM_152458.6. [A8K8V0-1]
XP_005255193.1. XM_005255136.1. [A8K8V0-1]
XP_006721085.1. XM_006721022.1. [A8K8V0-1]
UniGeneiHs.513509.

Genome annotation databases

EnsembliENST00000395216; ENSP00000378642; ENSG00000197162. [A8K8V0-1]
ENST00000470110; ENSP00000420340; ENSG00000197162. [A8K8V0-2]
GeneIDi146540.
KEGGihsa:146540.
UCSCiuc002dyv.2. human. [A8K8V0-2]
uc002dyw.2. human. [A8K8V0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056692 mRNA. Translation: BAB71256.1 .
AK292465 mRNA. Translation: BAF85154.1 .
CH471192 Genomic DNA. Translation: EAW52231.1 .
BC040642 mRNA. Translation: AAH40642.1 .
CCDSi CCDS10685.1. [A8K8V0-1 ]
RefSeqi NP_689671.2. NM_152458.6. [A8K8V0-1 ]
XP_005255193.1. XM_005255136.1. [A8K8V0-1 ]
XP_006721085.1. XM_006721022.1. [A8K8V0-1 ]
UniGenei Hs.513509.

3D structure databases

ProteinModelPortali A8K8V0.
SMRi A8K8V0. Positions 144-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126995. 1 interaction.
IntActi A8K8V0. 1 interaction.

PTM databases

PhosphoSitei A8K8V0.

Proteomic databases

PaxDbi A8K8V0.
PRIDEi A8K8V0.

Protocols and materials databases

DNASUi 146540.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395216 ; ENSP00000378642 ; ENSG00000197162 . [A8K8V0-1 ]
ENST00000470110 ; ENSP00000420340 ; ENSG00000197162 . [A8K8V0-2 ]
GeneIDi 146540.
KEGGi hsa:146540.
UCSCi uc002dyv.2. human. [A8K8V0-2 ]
uc002dyw.2. human. [A8K8V0-1 ]

Organism-specific databases

CTDi 146540.
GeneCardsi GC16M030590.
HGNCi HGNC:26496. ZNF785.
neXtProti NX_A8K8V0.
PharmGKBi PA162410467.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00560000077257.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi A8K8V0.
KOi K09228.
OMAi DCSLRFA.
PhylomeDBi A8K8V0.
TreeFami TF337922.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF785. human.
GenomeRNAii 146540.
NextBioi 85385.
PROi A8K8V0.

Gene expression databases

Bgeei A8K8V0.
CleanExi HS_ZNF785.
ExpressionAtlasi A8K8V0. baseline and differential.
Genevestigatori A8K8V0.

Family and domain databases

Gene3Di 3.30.160.60. 7 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Peripheral blood monocyte and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZN785_HUMAN
AccessioniPrimary (citable) accession number: A8K8V0
Secondary accession number(s): O75701
, Q8IW91, Q8WV14, Q96MN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3