A8K8V0 (ZN785_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 785

Gene names

Name:

ZNF785

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 7 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A8K8V0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A8K8V0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     98-112: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Zinc finger protein 785		PRO_0000345630
Regions
	Domain	29 – 100	72	KRAB
	Zinc finger	172 – 194	23	C2H2-type 1
	Zinc finger	200 – 222	23	C2H2-type 2
	Zinc finger	228 – 250	23	C2H2-type 3
	Zinc finger	256 – 278	23	C2H2-type 4
	Zinc finger	284 – 306	23	C2H2-type 5
	Zinc finger	312 – 334	23	C2H2-type 6
	Zinc finger	340 – 362	23	C2H2-type 7
Natural variations
	Alternative sequence	98 – 112	15	Missing in isoform 2.		VSP_034965

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 521391E814B117F0	FASTA	405	46,168
	10 20 30 40 50 60 MGPPLAPRPA HVPGEAGPRR TRESRPGAVS FADVAVYFSP EEWECLRPAQ RALYRDVMRE 70 80 90 100 110 120 TFGHLGALGF SVPKPAFISW VEGEVEAWSP EAQDPDGESS AAFSRGQGQE AGSRDGNEEK 130 140 150 160 170 180 ERLKKCPKQK EVAHEVAVKE WWPSVACPEF CNPRQSPMNP WLKDTLTRRL PHSCPDCGRN 190 200 210 220 230 240 FSYPSLLASH QRVHSGERPF SCGQCQARFS QRRYLLQHQF IHTGEKPYPC PDCGRRFRQR 250 260 270 280 290 300 GSLAIHRRAH TGEKPYACSD CKSRFTYPYL LAIHQRKHTG EKPYSCPDCS LRFAYTSLLA 310 320 330 340 350 360 IHRRIHTGEK PYPCPDCGRR FTYSSLLLSH RRIHSDSRPF PCVECGKGFK RKTALEAHRW 370 380 390 400 IHRSCSERRA WQQAVVGRSE PIPVLGGKDP PVHFRHFPDI FQECG
	Isoform 2 [UniParc]. Checksum: E490E652E9A91709	FASTA	390	44,705
	10 20 30 40 50 60 MGPPLAPRPA HVPGEAGPRR TRESRPGAVS FADVAVYFSP EEWECLRPAQ RALYRDVMRE 70 80 90 100 110 120 TFGHLGALGF SVPKPAFISW VEGEVEAWSP EAQDPDGSRD GNEEKERLKK CPKQKEVAHE 130 140 150 160 170 180 VAVKEWWPSV ACPEFCNPRQ SPMNPWLKDT LTRRLPHSCP DCGRNFSYPS LLASHQRVHS 190 200 210 220 230 240 GERPFSCGQC QARFSQRRYL LQHQFIHTGE KPYPCPDCGR RFRQRGSLAI HRRAHTGEKP 250 260 270 280 290 300 YACSDCKSRF TYPYLLAIHQ RKHTGEKPYS CPDCSLRFAY TSLLAIHRRI HTGEKPYPCP 310 320 330 340 350 360 DCGRRFTYSS LLLSHRRIHS DSRPFPCVEC GKGFKRKTAL EAHRWIHRSC SERRAWQQAV 370 380 390 VGRSEPIPVL GGKDPPVHFR HFPDIFQECG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Peripheral blood monocyte and Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056692 mRNA. Translation: BAB71256.1. AK292465 mRNA. Translation: BAF85154.1. CH471192 Genomic DNA. Translation: EAW52231.1. BC040642 mRNA. Translation: AAH40642.1.
IPI	IPI00065551. IPI00743874.
RefSeq	NP_689671.2. NM_152458.6.
UniGene	Hs.513509.
3D structure databases
ProteinModelPortal	A8K8V0.
ModBase	Search...
Protein-protein interaction databases
IntAct	A8K8V0. 1 interaction.
PTM databases
PhosphoSite	A8K8V0.
Proteomic databases
PaxDb	A8K8V0.
PRIDE	A8K8V0.
Protocols and materials databases
DNASU	146540.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395216; ENSP00000378642; ENSG00000197162. ENST00000470110; ENSP00000420340; ENSG00000197162.
GeneID	146540.
KEGG	hsa:146540.
UCSC	uc002dyv.2. human. uc002dyw.2. human.
Organism-specific databases
CTD	146540.
GeneCards	GC16M030590.
HGNC	HGNC:26496. ZNF785.
neXtProt	NX_A8K8V0.
PharmGKB	PA162410467.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
KO	K09228.
OMA	DCSLRFA.
PhylomeDB	A8K8V0.
Gene expression databases
ArrayExpress	A8K8V0.
Bgee	A8K8V0.
CleanEx	HS_ZNF785.
Genevestigator	A8K8V0.
Family and domain databases
Gene3D	3.30.160.60. 7 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 7 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF785. human.
GenomeRNAi	146540.
NextBio	85385.

Entry information

Entry name

ZN785_HUMAN

Accession

Primary (citable) accession number: A8K8V0
Secondary accession number(s): O75701 , Q8IW91, Q8WV14, Q96MN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.