Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8K8V0

- ZN785_HUMAN

UniProt

A8K8V0 - ZN785_HUMAN

Protein

Zinc finger protein 785

Gene

ZNF785

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 785
    Gene namesi
    Name:ZNF785
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26496. ZNF785.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410467.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Zinc finger protein 785PRO_0000345630Add
    BLAST

    Proteomic databases

    PaxDbiA8K8V0.
    PRIDEiA8K8V0.

    PTM databases

    PhosphoSiteiA8K8V0.

    Expressioni

    Gene expression databases

    ArrayExpressiA8K8V0.
    BgeeiA8K8V0.
    CleanExiHS_ZNF785.
    GenevestigatoriA8K8V0.

    Interactioni

    Protein-protein interaction databases

    BioGridi126995. 1 interaction.
    IntActiA8K8V0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliA8K8V0.
    SMRiA8K8V0. Positions 144-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 10072KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    KOiK09228.
    OMAiDCSLRFA.
    PhylomeDBiA8K8V0.
    TreeFamiTF337922.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A8K8V0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPPLAPRPA HVPGEAGPRR TRESRPGAVS FADVAVYFSP EEWECLRPAQ    50
    RALYRDVMRE TFGHLGALGF SVPKPAFISW VEGEVEAWSP EAQDPDGESS 100
    AAFSRGQGQE AGSRDGNEEK ERLKKCPKQK EVAHEVAVKE WWPSVACPEF 150
    CNPRQSPMNP WLKDTLTRRL PHSCPDCGRN FSYPSLLASH QRVHSGERPF 200
    SCGQCQARFS QRRYLLQHQF IHTGEKPYPC PDCGRRFRQR GSLAIHRRAH 250
    TGEKPYACSD CKSRFTYPYL LAIHQRKHTG EKPYSCPDCS LRFAYTSLLA 300
    IHRRIHTGEK PYPCPDCGRR FTYSSLLLSH RRIHSDSRPF PCVECGKGFK 350
    RKTALEAHRW IHRSCSERRA WQQAVVGRSE PIPVLGGKDP PVHFRHFPDI 400
    FQECG 405
    Length:405
    Mass (Da):46,168
    Last modified:December 4, 2007 - v1
    Checksum:i521391E814B117F0
    GO
    Isoform 2 (identifier: A8K8V0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         98-112: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:390
    Mass (Da):44,705
    Checksum:iE490E652E9A91709
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei98 – 11215Missing in isoform 2. 1 PublicationVSP_034965Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056692 mRNA. Translation: BAB71256.1.
    AK292465 mRNA. Translation: BAF85154.1.
    CH471192 Genomic DNA. Translation: EAW52231.1.
    BC040642 mRNA. Translation: AAH40642.1.
    CCDSiCCDS10685.1. [A8K8V0-1]
    RefSeqiNP_689671.2. NM_152458.6. [A8K8V0-1]
    XP_005255193.1. XM_005255136.1. [A8K8V0-1]
    XP_006721085.1. XM_006721022.1. [A8K8V0-1]
    UniGeneiHs.513509.

    Genome annotation databases

    EnsembliENST00000395216; ENSP00000378642; ENSG00000197162. [A8K8V0-1]
    ENST00000470110; ENSP00000420340; ENSG00000197162. [A8K8V0-2]
    GeneIDi146540.
    KEGGihsa:146540.
    UCSCiuc002dyv.2. human. [A8K8V0-2]
    uc002dyw.2. human. [A8K8V0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056692 mRNA. Translation: BAB71256.1 .
    AK292465 mRNA. Translation: BAF85154.1 .
    CH471192 Genomic DNA. Translation: EAW52231.1 .
    BC040642 mRNA. Translation: AAH40642.1 .
    CCDSi CCDS10685.1. [A8K8V0-1 ]
    RefSeqi NP_689671.2. NM_152458.6. [A8K8V0-1 ]
    XP_005255193.1. XM_005255136.1. [A8K8V0-1 ]
    XP_006721085.1. XM_006721022.1. [A8K8V0-1 ]
    UniGenei Hs.513509.

    3D structure databases

    ProteinModelPortali A8K8V0.
    SMRi A8K8V0. Positions 144-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126995. 1 interaction.
    IntActi A8K8V0. 1 interaction.

    PTM databases

    PhosphoSitei A8K8V0.

    Proteomic databases

    PaxDbi A8K8V0.
    PRIDEi A8K8V0.

    Protocols and materials databases

    DNASUi 146540.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395216 ; ENSP00000378642 ; ENSG00000197162 . [A8K8V0-1 ]
    ENST00000470110 ; ENSP00000420340 ; ENSG00000197162 . [A8K8V0-2 ]
    GeneIDi 146540.
    KEGGi hsa:146540.
    UCSCi uc002dyv.2. human. [A8K8V0-2 ]
    uc002dyw.2. human. [A8K8V0-1 ]

    Organism-specific databases

    CTDi 146540.
    GeneCardsi GC16M030590.
    HGNCi HGNC:26496. ZNF785.
    neXtProti NX_A8K8V0.
    PharmGKBi PA162410467.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    KOi K09228.
    OMAi DCSLRFA.
    PhylomeDBi A8K8V0.
    TreeFami TF337922.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF785. human.
    GenomeRNAii 146540.
    NextBioi 85385.
    PROi A8K8V0.

    Gene expression databases

    ArrayExpressi A8K8V0.
    Bgeei A8K8V0.
    CleanExi HS_ZNF785.
    Genevestigatori A8K8V0.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Peripheral blood monocyte and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiZN785_HUMAN
    AccessioniPrimary (citable) accession number: A8K8V0
    Secondary accession number(s): O75701
    , Q8IW91, Q8WV14, Q96MN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3