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A8K8V0 (ZN785_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 785
Gene names
Name:ZNF785
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A8K8V0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A8K8V0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     98-112: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Zinc finger protein 785
PRO_0000345630

Regions

Domain29 – 10072KRAB
Zinc finger172 – 19423C2H2-type 1
Zinc finger200 – 22223C2H2-type 2
Zinc finger228 – 25023C2H2-type 3
Zinc finger256 – 27823C2H2-type 4
Zinc finger284 – 30623C2H2-type 5
Zinc finger312 – 33423C2H2-type 6
Zinc finger340 – 36223C2H2-type 7

Natural variations

Alternative sequence98 – 11215Missing in isoform 2.
VSP_034965

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 521391E814B117F0

FASTA40546,168
        10         20         30         40         50         60 
MGPPLAPRPA HVPGEAGPRR TRESRPGAVS FADVAVYFSP EEWECLRPAQ RALYRDVMRE 

        70         80         90        100        110        120 
TFGHLGALGF SVPKPAFISW VEGEVEAWSP EAQDPDGESS AAFSRGQGQE AGSRDGNEEK 

       130        140        150        160        170        180 
ERLKKCPKQK EVAHEVAVKE WWPSVACPEF CNPRQSPMNP WLKDTLTRRL PHSCPDCGRN 

       190        200        210        220        230        240 
FSYPSLLASH QRVHSGERPF SCGQCQARFS QRRYLLQHQF IHTGEKPYPC PDCGRRFRQR 

       250        260        270        280        290        300 
GSLAIHRRAH TGEKPYACSD CKSRFTYPYL LAIHQRKHTG EKPYSCPDCS LRFAYTSLLA 

       310        320        330        340        350        360 
IHRRIHTGEK PYPCPDCGRR FTYSSLLLSH RRIHSDSRPF PCVECGKGFK RKTALEAHRW 

       370        380        390        400 
IHRSCSERRA WQQAVVGRSE PIPVLGGKDP PVHFRHFPDI FQECG 

« Hide

Isoform 2 [UniParc].

Checksum: E490E652E9A91709
Show »

FASTA39044,705

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Peripheral blood monocyte and Testis.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056692 mRNA. Translation: BAB71256.1.
AK292465 mRNA. Translation: BAF85154.1.
CH471192 Genomic DNA. Translation: EAW52231.1.
BC040642 mRNA. Translation: AAH40642.1.
CCDSCCDS10685.1. [A8K8V0-1]
RefSeqNP_689671.2. NM_152458.6. [A8K8V0-1]
XP_005255193.1. XM_005255136.1. [A8K8V0-1]
XP_006721085.1. XM_006721022.1. [A8K8V0-1]
UniGeneHs.513509.

3D structure databases

ProteinModelPortalA8K8V0.
SMRA8K8V0. Positions 144-398.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126995. 1 interaction.
IntActA8K8V0. 1 interaction.

PTM databases

PhosphoSiteA8K8V0.

Proteomic databases

PaxDbA8K8V0.
PRIDEA8K8V0.

Protocols and materials databases

DNASU146540.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395216; ENSP00000378642; ENSG00000197162. [A8K8V0-1]
ENST00000470110; ENSP00000420340; ENSG00000197162. [A8K8V0-2]
GeneID146540.
KEGGhsa:146540.
UCSCuc002dyv.2. human. [A8K8V0-2]
uc002dyw.2. human. [A8K8V0-1]

Organism-specific databases

CTD146540.
GeneCardsGC16M030590.
HGNCHGNC:26496. ZNF785.
neXtProtNX_A8K8V0.
PharmGKBPA162410467.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
KOK09228.
OMADCSLRFA.
PhylomeDBA8K8V0.
TreeFamTF337922.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressA8K8V0.
BgeeA8K8V0.
CleanExHS_ZNF785.
GenevestigatorA8K8V0.

Family and domain databases

Gene3D3.30.160.60. 7 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF785. human.
GenomeRNAi146540.
NextBio85385.
PROA8K8V0.

Entry information

Entry nameZN785_HUMAN
AccessionPrimary (citable) accession number: A8K8V0
Secondary accession number(s): O75701 expand/collapse secondary AC list , Q8IW91, Q8WV14, Q96MN0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM