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Protein

Zinc finger protein 785

Gene

ZNF785

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31623-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 785
Gene namesi
Name:ZNF785
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26496. ZNF785.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197162.
PharmGKBiPA162410467.

Polymorphism and mutation databases

BioMutaiZNF785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003456301 – 405Zinc finger protein 785Add BLAST405

Proteomic databases

PaxDbiA8K8V0.
PRIDEiA8K8V0.

PTM databases

iPTMnetiA8K8V0.
PhosphoSitePlusiA8K8V0.

Expressioni

Gene expression databases

BgeeiENSG00000197162.
CleanExiHS_ZNF785.
ExpressionAtlasiA8K8V0. baseline and differential.
GenevisibleiA8K8V0. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EHMT2A2ABF93EBI-3925400,EBI-10174566
HOOK1Q9UJC33EBI-3925400,EBI-746704
KRTAP10-5P603703EBI-3925400,EBI-10172150
MID2Q9UJV3-23EBI-3925400,EBI-10172526
MTUS2Q5JR593EBI-3925400,EBI-742948

Protein-protein interaction databases

BioGridi126995. 72 interactors.
IntActiA8K8V0. 16 interactors.
STRINGi9606.ENSP00000378642.

Structurei

3D structure databases

ProteinModelPortaliA8K8V0.
SMRiA8K8V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8K8V0.
KOiK09228.
OMAiDCSLRFA.
OrthoDBiEOG091G0P6J.
PhylomeDBiA8K8V0.
TreeFamiTF337922.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8K8V0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPLAPRPA HVPGEAGPRR TRESRPGAVS FADVAVYFSP EEWECLRPAQ
60 70 80 90 100
RALYRDVMRE TFGHLGALGF SVPKPAFISW VEGEVEAWSP EAQDPDGESS
110 120 130 140 150
AAFSRGQGQE AGSRDGNEEK ERLKKCPKQK EVAHEVAVKE WWPSVACPEF
160 170 180 190 200
CNPRQSPMNP WLKDTLTRRL PHSCPDCGRN FSYPSLLASH QRVHSGERPF
210 220 230 240 250
SCGQCQARFS QRRYLLQHQF IHTGEKPYPC PDCGRRFRQR GSLAIHRRAH
260 270 280 290 300
TGEKPYACSD CKSRFTYPYL LAIHQRKHTG EKPYSCPDCS LRFAYTSLLA
310 320 330 340 350
IHRRIHTGEK PYPCPDCGRR FTYSSLLLSH RRIHSDSRPF PCVECGKGFK
360 370 380 390 400
RKTALEAHRW IHRSCSERRA WQQAVVGRSE PIPVLGGKDP PVHFRHFPDI

FQECG
Length:405
Mass (Da):46,168
Last modified:December 4, 2007 - v1
Checksum:i521391E814B117F0
GO
Isoform 2 (identifier: A8K8V0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-112: Missing.

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):44,705
Checksum:iE490E652E9A91709
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076389316D → G.1 Publication1
Natural variantiVAR_076390337S → R.1 PublicationCorresponds to variant rs201574418dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03496598 – 112Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056692 mRNA. Translation: BAB71256.1.
AK292465 mRNA. Translation: BAF85154.1.
CH471192 Genomic DNA. Translation: EAW52231.1.
BC040642 mRNA. Translation: AAH40642.1.
CCDSiCCDS10685.1. [A8K8V0-1]
RefSeqiNP_689671.2. NM_152458.6. [A8K8V0-1]
XP_016878456.1. XM_017022967.1. [A8K8V0-1]
UniGeneiHs.513509.
Hs.710991.

Genome annotation databases

EnsembliENST00000395216; ENSP00000378642; ENSG00000197162. [A8K8V0-1]
ENST00000470110; ENSP00000420340; ENSG00000197162. [A8K8V0-2]
GeneIDi146540.
KEGGihsa:146540.
UCSCiuc002dyv.3. human. [A8K8V0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056692 mRNA. Translation: BAB71256.1.
AK292465 mRNA. Translation: BAF85154.1.
CH471192 Genomic DNA. Translation: EAW52231.1.
BC040642 mRNA. Translation: AAH40642.1.
CCDSiCCDS10685.1. [A8K8V0-1]
RefSeqiNP_689671.2. NM_152458.6. [A8K8V0-1]
XP_016878456.1. XM_017022967.1. [A8K8V0-1]
UniGeneiHs.513509.
Hs.710991.

3D structure databases

ProteinModelPortaliA8K8V0.
SMRiA8K8V0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126995. 72 interactors.
IntActiA8K8V0. 16 interactors.
STRINGi9606.ENSP00000378642.

PTM databases

iPTMnetiA8K8V0.
PhosphoSitePlusiA8K8V0.

Polymorphism and mutation databases

BioMutaiZNF785.

Proteomic databases

PaxDbiA8K8V0.
PRIDEiA8K8V0.

Protocols and materials databases

DNASUi146540.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395216; ENSP00000378642; ENSG00000197162. [A8K8V0-1]
ENST00000470110; ENSP00000420340; ENSG00000197162. [A8K8V0-2]
GeneIDi146540.
KEGGihsa:146540.
UCSCiuc002dyv.3. human. [A8K8V0-1]

Organism-specific databases

CTDi146540.
GeneCardsiZNF785.
HGNCiHGNC:26496. ZNF785.
neXtProtiNX_A8K8V0.
OpenTargetsiENSG00000197162.
PharmGKBiPA162410467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8K8V0.
KOiK09228.
OMAiDCSLRFA.
OrthoDBiEOG091G0P6J.
PhylomeDBiA8K8V0.
TreeFamiTF337922.

Enzyme and pathway databases

BioCyciZFISH:G66-31623-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF785. human.
GenomeRNAii146540.
PROiA8K8V0.

Gene expression databases

BgeeiENSG00000197162.
CleanExiHS_ZNF785.
ExpressionAtlasiA8K8V0. baseline and differential.
GenevisibleiA8K8V0. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN785_HUMAN
AccessioniPrimary (citable) accession number: A8K8V0
Secondary accession number(s): O75701
, Q8IW91, Q8WV14, Q96MN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.