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Protein

Protein SFI1 homolog

Gene

SFI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31822-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SFI1 homolog
Short name:
hSFI1
Gene namesi
Name:SFI1
Synonyms:KIAA0542
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:29064. SFI1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi9814.
OpenTargetsiENSG00000198089.
PharmGKBiPA142670930.

Polymorphism and mutation databases

BioMutaiSFI1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346211 – 1242Protein SFI1 homologAdd BLAST1242

Proteomic databases

EPDiA8K8P3.
MaxQBiA8K8P3.
PaxDbiA8K8P3.
PRIDEiA8K8P3.

PTM databases

iPTMnetiA8K8P3.
PhosphoSitePlusiA8K8P3.

Expressioni

Gene expression databases

BgeeiENSG00000198089.
CleanExiHS_SFI1.
ExpressionAtlasiA8K8P3. baseline and differential.
GenevisibleiA8K8P3. HS.

Organism-specific databases

HPAiCAB011512.

Interactioni

Subunit structurei

Interacts with CETN2 (via C-terminus).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CETN2P412084EBI-743371,EBI-1789926
MAD2L2Q9UI953EBI-10321817,EBI-77889
PPP1CAP621362EBI-743371,EBI-357253

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115153. 19 interactors.
IntActiA8K8P3. 14 interactors.
MINTiMINT-4843289.
STRINGi9606.ENSP00000383145.

Structurei

Secondary structure

11242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi651 – 659Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2INMR-B641-660[»]
ProteinModelPortaliA8K8P3.
SMRiA8K8P3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA8K8P3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati138 – 170HAT 1Add BLAST33
Repeati172 – 201HAT 2Add BLAST30
Repeati270 – 302HAT 3Add BLAST33
Repeati334 – 368HAT 4Add BLAST35
Repeati399 – 431HAT 5Add BLAST33
Repeati1148 – 1180HAT 6Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 130Interaction with CETN2Add BLAST20
Regioni475 – 494Interaction with CETN2Add BLAST20
Regioni641 – 660Interaction with CETN2Add BLAST20

Domaini

CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.

Sequence similaritiesi

Belongs to the SFI1 family.Curated
Contains 6 HAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4775. Eukaryota.
ENOG4111JHQ. LUCA.
GeneTreeiENSGT00390000018445.
HOVERGENiHBG108479.
InParanoidiA8K8P3.
KOiK16489.
OMAiESQHNRQ.
OrthoDBiEOG091G0EXO.
PhylomeDBiA8K8P3.
TreeFamiTF328940.

Family and domain databases

InterProiIPR030516. SFI1.
[Graphical view]
PANTHERiPTHR22028:SF4. PTHR22028:SF4. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8K8P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNLLTEKCI SSHNFHQKVI KQRMEKKVDS RYFKDGAVKK PYSAKTLSNK
60 70 80 90 100
KSSASFGIRR ELPSTSHLVQ YRGTHTCTRQ GRLRELRIRC VARKFLYLWI
110 120 130 140 150
RMTFGRVFPS KARFYYEQRL LRKVFEEWKE EWWVFQHEWK LCVRADCHYR
160 170 180 190 200
YYLYNLMFQT WKTYVRQQQE MRNKYIRAEV HDAKQKMRQA WKSWLIYVVV
210 220 230 240 250
RRTKLQMQTT ALEFRQRIIL RVWWSTWRQR LGQVRVSRAL HASALKHRAL
260 270 280 290 300
SLQVQAWSQW REQLLYVQKE KQKVVSAVKH HQHWQKRRFL KAWLEYLQVR
310 320 330 340 350
RVKRQQNEMA ERFHHVTVLQ IYFCDWQQAW ERRESLYAHH AQVEKLARKM
360 370 380 390 400
ALRRAFTHWK HYMLLCAEEA AQFEMAEEHH RHSQLYFCFR ALKDNVTHAH
410 420 430 440 450
LQQIRRNLAH QQHGVTLLHR FWNLWRSQIE QKKERELLPL LHAAWDHYRI
460 470 480 490 500
ALLCKCIELW LQYTQKRRYK QLLQARADGH FQQRALPAAF HTWNRLWRWR
510 520 530 540 550
HQENVLSARA TRFHRETLEK QVFSLWRQKM FQHRENRLAE RMAILHAERQ
560 570 580 590 600
LLYRSWFMWH QQAAARHQEQ EWQTVACAHH RHGRLKKAFC LWRESAQGLR
610 620 630 640 650
TERTGRVRAA EFHMAQLLRW AWSQWRECLA LRGAERQKLM RADLHHQHSV
660 670 680 690 700
LHRALQAWVT YQGRVRSILR EVAARESQHN RQLLRGALRR WKENTMARVD
710 720 730 740 750
EAKKTFQAST HYRRTICSKV LVQWREAVSV QMYYRQQEDC AIWEAQKVLD
760 770 780 790 800
RGCLRTWFQR WWDCSRRSAQ QRLQLERAVQ HHHRQLLLEG LARWKTHHLQ
810 820 830 840 850
CVRKRLLHRQ STQLLAQRLS RTCFRQWRQQ LAARRQEQRA TVRALWFWAF
860 870 880 890 900
SLQAKVWATW LAFVLERRRK KARLQWALQA YQGQLLQEGA TRLLRFAASM
910 920 930 940 950
KASRQQLQAQ QQVQAAHSLH RAVRRCATLW KQKVLGRGGK PQPLAAIAPS
960 970 980 990 1000
RKVTFEGPLL NRIAAGAGDG TLETKRPQAS RPLGALGRLA AEEPHALELN
1010 1020 1030 1040 1050
TAHSARKQPR RPHFLLEPAQ SQRPQKPQEH GLGMAQPAAP SLTRPFLAEA
1060 1070 1080 1090 1100
PTALVPHSPL PGALSSAPGP KQPPTASTGP ELLLLPLSSF MPCGAAAPAR
1110 1120 1130 1140 1150
VSAQRATPRD KPPVPSSLAS VPDPHLLLPG DFSATRAGPG LSTAGSLDLE
1160 1170 1180 1190 1200
AELEEIQQQL LHYQTTKQNL WSCRRQASSL RRWLELNREE PGPEDQEVEQ
1210 1220 1230 1240
QVQKELEQVE MQIQLLAEEL QAQRQPIGAC VARIQALRQA LC
Length:1,242
Mass (Da):147,664
Last modified:May 20, 2008 - v2
Checksum:i7BE570BDD7F72B6E
GO
Isoform 2 (identifier: A8K8P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-416: Missing.

Show »
Length:1,211
Mass (Da):143,978
Checksum:i4F7038E1D184A505
GO
Isoform 3 (identifier: A8K8P3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.

Note: No experimental confirmation available.
Show »
Length:1,160
Mass (Da):138,070
Checksum:iC3560EAD4217A72E
GO
Isoform 4 (identifier: A8K8P3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.
     150-220: Missing.
     1145-1242: GSLDLEAELE...RIQALRQALC → AWTLRLNLRR...KRAACAGGWS

Note: No experimental confirmation available.
Show »
Length:1,031
Mass (Da):121,826
Checksum:i108E39A21FE58AC5
GO
Isoform 5 (identifier: A8K8P3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-112: Missing.
     678-904: Missing.

Note: No experimental confirmation available.
Show »
Length:991
Mass (Da):117,079
Checksum:i677D443FAF8A82E5
GO
Isoform 9 (identifier: A8K8P3-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-112: Missing.
     386-416: Missing.

Note: No experimental confirmation available.
Show »
Length:1,187
Mass (Da):141,050
Checksum:i517294BE383E1B0F
GO
Isoform 10 (identifier: A8K8P3-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-112: Missing.
     708-719: Missing.

Note: No experimental confirmation available.
Show »
Length:1,148
Mass (Da):136,666
Checksum:i1859FC8789A47186
GO

Sequence cautioni

The sequence AAI10815 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI29927 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25468 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH70755 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI23034 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM13202 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM14701 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM28334 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAX14857 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAX14858 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAX15240 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAX15241 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353R → W in AAI10815 (PubMed:15489334).Curated1
Sequence conflicti622W → R in AAI29927 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04343913H → L.Corresponds to variant rs5749290dbSNPEnsembl.1
Natural variantiVAR_04344072R → H.Corresponds to variant rs16989698dbSNPEnsembl.1
Natural variantiVAR_043441167Q → H.Corresponds to variant rs7511430dbSNPEnsembl.1
Natural variantiVAR_043442322Y → H.3 PublicationsCorresponds to variant rs5753700dbSNPEnsembl.1
Natural variantiVAR_043443330W → R.Corresponds to variant rs16989291dbSNPEnsembl.1
Natural variantiVAR_043444549R → Q.2 PublicationsCorresponds to variant rs2006771dbSNPEnsembl.1
Natural variantiVAR_062234760R → H.Corresponds to variant rs9621295dbSNPEnsembl.1
Natural variantiVAR_0434451087L → P.3 PublicationsCorresponds to variant rs12171042dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03369931 – 112Missing in isoform 3, isoform 4 and isoform 10. 2 PublicationsAdd BLAST82
Alternative sequenceiVSP_03370089 – 112Missing in isoform 5 and isoform 9. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_033701150 – 220Missing in isoform 4. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_033702386 – 416Missing in isoform 2 and isoform 9. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_033703678 – 904Missing in isoform 5. 1 PublicationAdd BLAST227
Alternative sequenceiVSP_038325708 – 719Missing in isoform 10. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0337081145 – 1242GSLDL…RQALC → AWTLRLNLRRSSSNYCTTRP PSRTSGPVGGKRAACAGGWS in isoform 4. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011114 mRNA. Translation: BAA25468.2. Different initiation.
AK292408 mRNA. Translation: BAF85097.1.
AK293987 mRNA. Translation: BAH11642.1.
AK303362 mRNA. Translation: BAH13949.1.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAH70755.2. Different initiation.
AL096701, AL096768, AL109802 Genomic DNA. Translation: CAI12881.1.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAI23034.2. Different initiation.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAM13202.2. Different initiation.
AL096701, AL096768, AL109802 Genomic DNA. Translation: CAM14700.1.
AL096701 Genomic DNA. Translation: CAM14701.1. Sequence problems.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAM28334.2. Different initiation.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAX14857.1. Different initiation.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAX14858.1. Different initiation.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAX15240.1. Different initiation.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAX15241.1. Different initiation.
BC021576 mRNA. Translation: AAH21576.1.
BC110814 mRNA. Translation: AAI10815.1. Different initiation.
BC129926 mRNA. Translation: AAI29927.1. Different initiation.
BC129945 mRNA. Translation: AAI29946.1.
CCDSiCCDS43004.1. [A8K8P3-1]
CCDS43005.1. [A8K8P3-2]
CCDS58803.1. [A8K8P3-9]
CCDS58804.1. [A8K8P3-3]
PIRiT00322.
RefSeqiNP_001007468.1. NM_001007467.2. [A8K8P3-1]
NP_001245254.1. NM_001258325.1. [A8K8P3-9]
NP_001245255.1. NM_001258326.1. [A8K8P3-3]
NP_001245256.1. NM_001258327.1. [A8K8P3-10]
NP_055590.2. NM_014775.3. [A8K8P3-2]
XP_006724453.1. XM_006724390.2. [A8K8P3-3]
XP_016884640.1. XM_017029151.1. [A8K8P3-2]
XP_016884643.1. XM_017029154.1. [A8K8P3-9]
UniGeneiHs.62209.
Hs.742373.

Genome annotation databases

EnsembliENST00000400288; ENSP00000383145; ENSG00000198089. [A8K8P3-1]
ENST00000400289; ENSP00000383146; ENSG00000198089. [A8K8P3-3]
ENST00000432498; ENSP00000402679; ENSG00000198089. [A8K8P3-2]
ENST00000540643; ENSP00000443025; ENSG00000198089. [A8K8P3-9]
GeneIDi9814.
KEGGihsa:9814.
UCSCiuc003ale.5. human. [A8K8P3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011114 mRNA. Translation: BAA25468.2. Different initiation.
AK292408 mRNA. Translation: BAF85097.1.
AK293987 mRNA. Translation: BAH11642.1.
AK303362 mRNA. Translation: BAH13949.1.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAH70755.2. Different initiation.
AL096701, AL096768, AL109802 Genomic DNA. Translation: CAI12881.1.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAI23034.2. Different initiation.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAM13202.2. Different initiation.
AL096701, AL096768, AL109802 Genomic DNA. Translation: CAM14700.1.
AL096701 Genomic DNA. Translation: CAM14701.1. Sequence problems.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAM28334.2. Different initiation.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAX14857.1. Different initiation.
AL096768, AL096701, AL109802 Genomic DNA. Translation: CAX14858.1. Different initiation.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAX15240.1. Different initiation.
AL109802, AL096701, AL096768 Genomic DNA. Translation: CAX15241.1. Different initiation.
BC021576 mRNA. Translation: AAH21576.1.
BC110814 mRNA. Translation: AAI10815.1. Different initiation.
BC129926 mRNA. Translation: AAI29927.1. Different initiation.
BC129945 mRNA. Translation: AAI29946.1.
CCDSiCCDS43004.1. [A8K8P3-1]
CCDS43005.1. [A8K8P3-2]
CCDS58803.1. [A8K8P3-9]
CCDS58804.1. [A8K8P3-3]
PIRiT00322.
RefSeqiNP_001007468.1. NM_001007467.2. [A8K8P3-1]
NP_001245254.1. NM_001258325.1. [A8K8P3-9]
NP_001245255.1. NM_001258326.1. [A8K8P3-3]
NP_001245256.1. NM_001258327.1. [A8K8P3-10]
NP_055590.2. NM_014775.3. [A8K8P3-2]
XP_006724453.1. XM_006724390.2. [A8K8P3-3]
XP_016884640.1. XM_017029151.1. [A8K8P3-2]
XP_016884643.1. XM_017029154.1. [A8K8P3-9]
UniGeneiHs.62209.
Hs.742373.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2INMR-B641-660[»]
ProteinModelPortaliA8K8P3.
SMRiA8K8P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115153. 19 interactors.
IntActiA8K8P3. 14 interactors.
MINTiMINT-4843289.
STRINGi9606.ENSP00000383145.

PTM databases

iPTMnetiA8K8P3.
PhosphoSitePlusiA8K8P3.

Polymorphism and mutation databases

BioMutaiSFI1.

Proteomic databases

EPDiA8K8P3.
MaxQBiA8K8P3.
PaxDbiA8K8P3.
PRIDEiA8K8P3.

Protocols and materials databases

DNASUi9814.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400288; ENSP00000383145; ENSG00000198089. [A8K8P3-1]
ENST00000400289; ENSP00000383146; ENSG00000198089. [A8K8P3-3]
ENST00000432498; ENSP00000402679; ENSG00000198089. [A8K8P3-2]
ENST00000540643; ENSP00000443025; ENSG00000198089. [A8K8P3-9]
GeneIDi9814.
KEGGihsa:9814.
UCSCiuc003ale.5. human. [A8K8P3-1]

Organism-specific databases

CTDi9814.
DisGeNETi9814.
GeneCardsiSFI1.
H-InvDBHIX0016393.
HGNCiHGNC:29064. SFI1.
HPAiCAB011512.
MIMi612765. gene.
neXtProtiNX_A8K8P3.
OpenTargetsiENSG00000198089.
PharmGKBiPA142670930.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4775. Eukaryota.
ENOG4111JHQ. LUCA.
GeneTreeiENSGT00390000018445.
HOVERGENiHBG108479.
InParanoidiA8K8P3.
KOiK16489.
OMAiESQHNRQ.
OrthoDBiEOG091G0EXO.
PhylomeDBiA8K8P3.
TreeFamiTF328940.

Enzyme and pathway databases

BioCyciZFISH:G66-31822-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiSFI1. human.
EvolutionaryTraceiA8K8P3.
GenomeRNAii9814.
PROiA8K8P3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198089.
CleanExiHS_SFI1.
ExpressionAtlasiA8K8P3. baseline and differential.
GenevisibleiA8K8P3. HS.

Family and domain databases

InterProiIPR030516. SFI1.
[Graphical view]
PANTHERiPTHR22028:SF4. PTHR22028:SF4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSFI1_HUMAN
AccessioniPrimary (citable) accession number: A8K8P3
Secondary accession number(s): A1L373
, A1L387, A2A2L2, B1AKL9, B5MDB7, B7Z1V6, B7Z8G3, B7ZBE2, B7ZBE3, O60289, Q2TAN8, Q5W1B5, Q86TK0, Q8N4U8, Q8N8C1, Q8WU14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.