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Protein

tRNA (guanine(26)-N(2))-dimethyltransferase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26) in tRNA.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri600 – 627C3H1-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, RNA-binding, Transferase, tRNA-bindingPROSITE-ProRule annotation
Biological processtRNA processingPROSITE-ProRule annotation
LigandMetal-binding, S-adenosyl-L-methioninePROSITE-ProRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine(26)-N(2))-dimethyltransferasePROSITE-ProRule annotation (EC:2.1.1.216PROSITE-ProRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134867808.

PTM / Processingi

Proteomic databases

PaxDbiA8K8L2.
PeptideAtlasiA8K8L2.
PRIDEiA8K8L2.

Expressioni

Gene expression databases

GenevisibleiA8K8L2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000350352.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini600 – 627C3H1-typeInterPro annotationAdd BLAST28

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri600 – 627C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1253. Eukaryota.
COG1867. LUCA.
HOVERGENiHBG000477.
KOiK00555.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR002905. Trm1.
IPR000571. Znf_CCCH.
PANTHERiPTHR10631. PTHR10631. 1 hit.
PfamiView protein in Pfam
PF02005. TRM. 1 hit.
PF00642. zf-CCCH. 1 hit.
SMARTiView protein in SMART
SM00356. ZnF_C3H1. 1 hit.
SUPFAMiSSF53335. SSF53335. 3 hits.
SSF90229. SSF90229. 1 hit.
TIGRFAMsiTIGR00308. TRM1. 1 hit.
PROSITEiView protein in PROSITE
PS51626. SAM_MT_TRM1. 1 hit.
PS50103. ZF_C3H1. 1 hit.

Sequencei

Sequence statusi: Complete.

A8K8L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGSSLWLSL TFRSARVLSR ARFFEWQSPG LPNTAAMENG TGPYGEERPR
60 70 80 90 100
EVQETTVTEG AAKIAFPSAN EVFYNPVQEF NRDLTCAVIT EFARVQLGAK
110 120 130 140 150
GIQIKVPGEK DTQKVVVDLS EQEEEKVELK GSENLASGDQ PRTAAVGEIC
160 170 180 190 200
EEGLHVLEGL AASGLRSIRF ALEVPGLRSV VANDASTRAV DLIRRNVQLN
210 220 230 240 250
DVAHLVQPSQ ADARMLMYQH QRVSERFDVI DLDPYGSPAT FLDAAVQAVS
260 270 280 290 300
EGGLLCVTCT DMAVLAGNSG ETCYSKYGAM ALKSRACHEM ALRIVLHSLD
310 320 330 340 350
LRANCYQRFV VPLLSISADF YVRVFVRVFT GQAKVKASAS KQALVFQCVG
360 370 380 390 400
CGAFHLQRLG KASGVPSGRA KFSAACGPPV TPECEHCGQR HQLGGPMWAE
410 420 430 440 450
PIHDLDFVGR VLEAVSANPG RFHTSERIRG VLSVITEELP DVPLYYTLDQ
460 470 480 490 500
LSSTIHCNTP SLLQLRSALL HADFRVSLSH ACKNAVKTDA PASALWDIMR
510 520 530 540 550
CWEKECPVKR ERLSETSPAF RILSVEPRLQ ANFTIREDAN PSSRQRGLKR
560 570 580 590 600
FQANPEANWG PRPRARPGGK AADEAMEERR RLLQNKRKEP PEDVAQRAAR
610 620 630 640 650
LKTFPCKRFK EGTCQRGDQC CYSHSPPTPR VSADAAPDCP ETSNQTPPGP

GAAAGPGID
Length:659
Mass (Da):72,148
Last modified:December 4, 2007 - v1
Checksum:iEC7B3345A66131E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292377 mRNA. Translation: BAF85066.1.
RefSeqiNP_001129507.1. NM_001136035.2.
UniGeneiHs.515169.

Genome annotation databases

GeneIDi55621.
KEGGihsa:55621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292377 mRNA. Translation: BAF85066.1.
RefSeqiNP_001129507.1. NM_001136035.2.
UniGeneiHs.515169.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350352.

Proteomic databases

PaxDbiA8K8L2.
PeptideAtlasiA8K8L2.
PRIDEiA8K8L2.

Protocols and materials databases

DNASUi55621.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi55621.
KEGGihsa:55621.

Organism-specific databases

CTDi55621.
PharmGKBiPA134867808.

Phylogenomic databases

eggNOGiKOG1253. Eukaryota.
COG1867. LUCA.
HOVERGENiHBG000477.
KOiK00555.

Miscellaneous databases

GenomeRNAii55621.

Gene expression databases

GenevisibleiA8K8L2. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR002905. Trm1.
IPR000571. Znf_CCCH.
PANTHERiPTHR10631. PTHR10631. 1 hit.
PfamiView protein in Pfam
PF02005. TRM. 1 hit.
PF00642. zf-CCCH. 1 hit.
SMARTiView protein in SMART
SM00356. ZnF_C3H1. 1 hit.
SUPFAMiSSF53335. SSF53335. 3 hits.
SSF90229. SSF90229. 1 hit.
TIGRFAMsiTIGR00308. TRM1. 1 hit.
PROSITEiView protein in PROSITE
PS51626. SAM_MT_TRM1. 1 hit.
PS50103. ZF_C3H1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA8K8L2_HUMAN
AccessioniPrimary (citable) accession number: A8K8L2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 12, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.