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Protein

Colorectal cancer-associated protein 2

Gene

COLCA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Colorectal cancer-associated protein 2
Alternative name(s):
Cancer susceptibility candidate protein 13
Gene namesi
Name:COLCA2
Synonyms:C11orf93, CASC13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000214290.7.
HGNCiHGNC:26978. COLCA2.
MIMi615694. gene.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi120376.
OpenTargetsiENSG00000214290.
PharmGKBiPA165543240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003356871 – 154Colorectal cancer-associated protein 2Add BLAST154

Proteomic databases

PaxDbiA8K830.
PRIDEiA8K830.

Expressioni

Tissue specificityi

Expressed in many cell types of epithelial, mesenchymal and hematopoietic origins.1 Publication

Gene expression databases

BgeeiENSG00000214290.
ExpressionAtlasiA8K830. baseline and differential.
GenevisibleiA8K830. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381115.

Structurei

3D structure databases

ProteinModelPortaliA8K830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWXK. Eukaryota.
ENOG410YUE4. LUCA.
GeneTreeiENSGT00420000030454.
HOGENOMiHOG000155600.
InParanoidiA8K830.
OMAiCYCASCE.
OrthoDBiEOG091G0KH5.
PhylomeDBiA8K830.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8K830-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPEPLLNST QSAPHHFPDS FQATPFCFNQ SLIPGSPSNS SILSGSLDYS
60 70 80 90 100
YSPVQLPSYA PENYNSPASL DTRTCGYPPE DHSYQHLSSH AQYSCFSSAT
110 120 130 140 150
TSICYCASCE AEDLDALQAA EYFYPSTDCV DFAPSAAATS DFYKRETNCD

ICYS
Length:154
Mass (Da):16,850
Last modified:December 4, 2007 - v1
Checksum:iFFFC596C75788FAB
GO
Isoform 2 (identifier: A8K830-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSDGARKRRR...IFDSYLQTEM

Show »
Length:328
Mass (Da):35,305
Checksum:iDB17B0FD06767282
GO
Isoform 3 (identifier: A8K830-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSEQRGTKSR...IFDSYLQTEM

Show »
Length:379
Mass (Da):41,151
Checksum:i83A5A098FBAEDE3A
GO
Isoform 4 (identifier: A8K830-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSDGARKRRR...IFDSYLQTEM

Show »
Length:286
Mass (Da):31,028
Checksum:iAFF4C036676C3E11
GO
Isoform 5 (identifier: A8K830-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSEKPKVYQG...IFDSYLQTEM

Show »
Length:251
Mass (Da):27,417
Checksum:iCDF0D94723FB6CDC
GO

Sequence cautioni

The sequence AAI10080 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AP002448 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555531M → MSDGARKRRRKGTRESGQKA KTEGSEGGSSSGLAPLLGQS AGTSPAQDGAGQTSPLAPGL ASRPRARRGRSLPRSHTWPE KPKVYQGVRVKITVKELLQQ RRAHQAASGGTRSGGSSVHL SDPVAPSSAGLYFEPEPISS TPNYLQRGEFSSCVSCEENS SCLDQIFDSYLQTEM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0555541M → MSEQRGTKSRHASKGRGSGE DASHAVAAPTQRLSRRAEAQ RPSWPLRTSAYPRPPPALPR IHCCVLRHAVRTLRAQKLLR GELEAHSEPGTGAERTDCTE PSCGGPCADPEGRPLPAESG ADRGTGWWGCEKPKVYQGVR VKITVKELLQQRRAHQAASG GTRSGGSSVHLSDPVAPSSA GLYFEPEPISSTPNYLQRGE FSSCVSCEENSSCLDQIFDS YLQTEM in isoform 3. 1 Publication1
Alternative sequenceiVSP_0555551M → MSDGARKRRRKGTRESGQKA KTEGSEGGSSSGLAPLLEKP KVYQGVRVKITVKELLQQRR AHQAASGGTRSGGSSVHLSD PVAPSSAGLYFEPEPISSTP NYLQRGEFSSCVSCEENSSC LDQIFDSYLQTEM in isoform 4. 1 Publication1
Alternative sequenceiVSP_0555561M → MSEKPKVYQGVRVKITVKEL LQQRRAHQAASGGTRSGGSS VHLSDPVAPSSAGLYFEPEP ISSTPNYLQRGEFSSCVSCE ENSSCLDQIFDSYLQTEM in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292195 mRNA. Translation: BAF84884.1.
KF740510 mRNA. Translation: AHA49743.1.
KF740511 mRNA. Translation: AHA49744.1.
KF740512 mRNA. Translation: AHA49745.1.
KF740513 mRNA. Translation: AHA49746.1.
KF740514 mRNA. Translation: AHA49747.1.
AP002448 Genomic DNA. No translation available.
BC110079 mRNA. Translation: AAI10080.1. Different initiation.
CCDSiCCDS44728.1. [A8K830-1]
CCDS73378.1. [A8K830-5]
RefSeqiNP_001129577.1. NM_001136105.2. [A8K830-1]
NP_001258386.1. NM_001271457.1. [A8K830-1]
NP_001258387.1. NM_001271458.1. [A8K830-5]
XP_016872687.1. XM_017017198.1. [A8K830-1]
XP_016872688.1. XM_017017199.1. [A8K830-1]
XP_016872689.1. XM_017017200.1. [A8K830-1]
UniGeneiHs.31409.
Hs.744409.
Hs.744538.

Genome annotation databases

EnsembliENST00000398035; ENSP00000381115; ENSG00000214290. [A8K830-1]
ENST00000526216; ENSP00000434519; ENSG00000214290. [A8K830-1]
ENST00000610738; ENSP00000484135; ENSG00000214290. [A8K830-5]
ENST00000614153; ENSP00000481028; ENSG00000214290. [A8K830-1]
ENST00000638573; ENSP00000492570; ENSG00000214290. [A8K830-4]
GeneIDi120376.
KEGGihsa:120376.
UCSCiuc010rwf.3. human. [A8K830-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCOLC2_HUMAN
AccessioniPrimary (citable) accession number: A8K830
Secondary accession number(s): E9PMJ8
, Q2TBJ3, V5LD62, V5LDI3, V5LDV1, V5LE09, V5LEU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 4, 2007
Last modified: September 27, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot